ATE368669T1 - C-substituierte trizyklische isoxazolin derivate und deren verwendung als anti-depressiva - Google Patents

C-substituierte trizyklische isoxazolin derivate und deren verwendung als anti-depressiva

Info

Publication number
ATE368669T1
ATE368669T1 AT03787817T AT03787817T ATE368669T1 AT E368669 T1 ATE368669 T1 AT E368669T1 AT 03787817 T AT03787817 T AT 03787817T AT 03787817 T AT03787817 T AT 03787817T AT E368669 T1 ATE368669 T1 AT E368669T1
Authority
AT
Austria
Prior art keywords
depressants
substituted tricyclic
isoxazoline derivatives
tricyclic isoxazoline
derivatives
Prior art date
Application number
AT03787817T
Other languages
English (en)
Inventor
Jose Ignacio Andres-Gil
Jose Manuel Bartolome-Nebreda
Rosa Maria Alvarez-Escobar
Margaretha Bakker
Antonius Adrianus Hendr Megens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE368669T1 publication Critical patent/ATE368669T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT03787817T 2002-08-12 2003-08-12 C-substituierte trizyklische isoxazolin derivate und deren verwendung als anti-depressiva ATE368669T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02078322 2002-08-12

Publications (1)

Publication Number Publication Date
ATE368669T1 true ATE368669T1 (de) 2007-08-15

Family

ID=31725449

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03787817T ATE368669T1 (de) 2002-08-12 2003-08-12 C-substituierte trizyklische isoxazolin derivate und deren verwendung als anti-depressiva

Country Status (15)

Country Link
US (1) US7465741B2 (de)
EP (1) EP1537124B1 (de)
JP (1) JP4681295B2 (de)
CN (1) CN1329396C (de)
AR (1) AR040967A1 (de)
AT (1) ATE368669T1 (de)
AU (1) AU2003262571B2 (de)
CA (1) CA2494235C (de)
DE (1) DE60315311T2 (de)
DK (1) DK1537124T3 (de)
ES (1) ES2290537T3 (de)
HK (1) HK1080080A1 (de)
PT (1) PT1537124E (de)
TW (1) TW200409777A (de)
WO (1) WO2004016621A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ536109A (en) * 2002-04-02 2006-06-30 Janssen Pharmaceutica Nv Substituted amino isoxazoline derivatives and their use as anti-depressants
CA2585857A1 (en) 2004-11-26 2006-06-01 Janssen Pharmaceutica N.V. Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic activity
CN102786515B (zh) * 2012-04-13 2014-07-23 湖南大学 2-（2,2-二甲基-2,3-二氢苯并呋喃-5-基）吗啉及其制备方法与应用
CN112374984A (zh) * 2020-11-06 2021-02-19 苏州求索生物科技有限公司 一种2-溴-4-羟基苯甲醚的制备工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68906340T2 (de) * 1988-09-19 1993-08-12 Akzo Nv Tetrahydronaphthalin und indan-derivate.
GB9318691D0 (en) * 1993-09-09 1993-10-27 Merck Sharp & Dohme Therapeutic agents
DE69415341T2 (de) * 1993-09-15 1999-07-15 Merck Sharp & Dohme Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor-subtyps
CN1058492C (zh) * 1993-12-24 2000-11-15 三得利株式会社 苯并噻嗪衍生物
HUP9903706A3 (en) * 1996-01-05 2000-09-28 Hoechst Marion Roussel Inc Cin 4,5-dihydronaphth[1,2-c]isoxazoles and derivatives thereof having cns activity, process for their preparation and pharmaceutical compositions containing the same
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
AU2980797A (en) * 1996-06-11 1998-01-07 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and medicinal uses thereof
AU765317C (en) * 1998-06-19 2004-05-20 H. Lundbeck A/S 4,5,6 and 7-indole and indoline derivatives, their preparation and use
CZ20032515A3 (cs) * 2001-02-21 2003-12-17 Janssen Pharmaceutica N. V. Isoxazolinové deriváty jako anti-depresivní činidla
NZ536109A (en) * 2002-04-02 2006-06-30 Janssen Pharmaceutica Nv Substituted amino isoxazoline derivatives and their use as anti-depressants
AU2003271567B2 (en) * 2002-08-21 2009-12-24 Janssen Pharmaceutica N.V. C6- and C9-substituted chromeno (4, 3-C) isoxazoline derivatives and their use as anti-depressants

Also Published As

Publication number Publication date
AR040967A1 (es) 2005-04-27
CA2494235A1 (en) 2004-02-26
WO2004016621A1 (en) 2004-02-26
DK1537124T3 (da) 2007-10-29
JP4681295B2 (ja) 2011-05-11
US20050256119A1 (en) 2005-11-17
EP1537124B1 (de) 2007-08-01
CA2494235C (en) 2011-10-11
EP1537124A1 (de) 2005-06-08
HK1080080A1 (zh) 2006-04-21
DE60315311D1 (de) 2007-09-13
CN1329396C (zh) 2007-08-01
ES2290537T3 (es) 2008-02-16
US7465741B2 (en) 2008-12-16
PT1537124E (pt) 2007-10-16
AU2003262571B2 (en) 2009-02-12
CN1675222A (zh) 2005-09-28
DE60315311T2 (de) 2008-04-17
AU2003262571A1 (en) 2004-03-03
TW200409777A (en) 2004-06-16
JP2005537304A (ja) 2005-12-08

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