DE60319951D1 - Aminocyclische substituierte pyrrolopyrimidinderivate und pyrrolopyridinderivate - Google Patents

Aminocyclische substituierte pyrrolopyrimidinderivate und pyrrolopyridinderivate

Info

Publication number
DE60319951D1
DE60319951D1 DE60319951T DE60319951T DE60319951D1 DE 60319951 D1 DE60319951 D1 DE 60319951D1 DE 60319951 T DE60319951 T DE 60319951T DE 60319951 T DE60319951 T DE 60319951T DE 60319951 D1 DE60319951 D1 DE 60319951D1
Authority
DE
Germany
Prior art keywords
derivatives
pyrrolopyrimidin
aminocyclic
substituted
pyrrolopyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60319951T
Other languages
English (en)
Other versions
DE60319951T2 (de
Inventor
Atsuro Nakazato
Taketoshi Okubo
Dai Nozawa
Mikako Yamaguchi
Tomoko Tamita
Ludo E J Kennis
Bruyn Marcel F L De
Jean-Pierre A M Bongartz
Den Keybus Frans M A Van
Roosbroeck Yves E M Van
Marcel G M Luyckx
Robert J M Hendrickx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of DE60319951D1 publication Critical patent/DE60319951D1/de
Application granted granted Critical
Publication of DE60319951T2 publication Critical patent/DE60319951T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
DE60319951T 2002-12-26 2003-12-24 Aminocyclische substituierte pyrrolopyrimidinderivate und pyrrolopyridinderivate Expired - Lifetime DE60319951T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002383667 2002-12-26
JP2002383667 2002-12-26
PCT/JP2003/016598 WO2004058767A1 (en) 2002-12-26 2003-12-24 Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group

Publications (2)

Publication Number Publication Date
DE60319951D1 true DE60319951D1 (de) 2008-05-08
DE60319951T2 DE60319951T2 (de) 2009-05-20

Family

ID=32677471

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60319951T Expired - Lifetime DE60319951T2 (de) 2002-12-26 2003-12-24 Aminocyclische substituierte pyrrolopyrimidinderivate und pyrrolopyridinderivate
DE60327477T Expired - Lifetime DE60327477D1 (de) 2002-12-26 2003-12-24 Pyrrolopyrimidin- und Pyrrolopyridin-Derivate substituiert durch eine cyklische Amingruppe

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60327477T Expired - Lifetime DE60327477D1 (de) 2002-12-26 2003-12-24 Pyrrolopyrimidin- und Pyrrolopyridin-Derivate substituiert durch eine cyklische Amingruppe

Country Status (23)

Country Link
US (3) US20050209253A1 (de)
EP (2) EP1467997B8 (de)
JP (1) JP4181126B2 (de)
KR (2) KR100808756B1 (de)
CN (1) CN1692115A (de)
AR (1) AR042667A1 (de)
AT (2) ATE430151T1 (de)
AU (1) AU2003292550B8 (de)
BR (1) BR0307587A (de)
CA (1) CA2485556C (de)
CL (1) CL2003002762A1 (de)
DE (2) DE60319951T2 (de)
EA (1) EA200401060A1 (de)
ES (2) ES2325596T3 (de)
HR (1) HRP20040724A2 (de)
MX (1) MXPA04008081A (de)
MY (1) MY141200A (de)
NO (1) NO20043508L (de)
PL (1) PL371810A1 (de)
TW (1) TWI270549B (de)
UA (1) UA77265C2 (de)
WO (1) WO2004058767A1 (de)
ZA (1) ZA200405982B (de)

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WO2005066142A2 (en) * 2004-01-06 2005-07-21 Taisho Pharmaceutical Co., Ltd. Pyrrolopyrimidine and pyrrolotriazine derivatives as crf receptor antagonists
RU2006128580A (ru) * 2004-01-06 2008-02-20 Тайсо Фармасьютикал Ко., Лтд. (Jp) Производные тиенопиримидина и тиенопиридина, замещенные циклической аминогруппой
JP4766393B2 (ja) 2004-01-06 2011-09-07 大正製薬株式会社 トリアザ−シクロペンタ［ｃｄ］インデン誘導体
JP2007526906A (ja) * 2004-03-05 2007-09-20 大正製薬株式会社 ピロロピリミジン誘導体
JP2007161585A (ja) * 2004-06-25 2007-06-28 Taisho Pharmaceut Co Ltd 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体
JP2008503443A (ja) * 2004-06-25 2008-02-07 大正製薬株式会社 テトラヒドロピリジンで置換されたピロロピリミジン及びピロロピリジンの誘導体
DE102004042607A1 (de) * 2004-09-03 2006-03-09 Bayer Healthcare Ag Substituierte Phenylaminothiazole und ihre Verwendung
DE102006042143A1 (de) * 2006-09-08 2008-03-27 Bayer Healthcare Aktiengesellschaft Neue substituierte Bipyridin-Derivate und ihre Verwendung
DE102006056739A1 (de) * 2006-12-01 2008-06-05 Bayer Healthcare Ag Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung
DE102006056740A1 (de) * 2006-12-01 2008-06-05 Bayer Healthcare Ag Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
DE102007035367A1 (de) 2007-07-27 2009-01-29 Bayer Healthcare Ag Substituierte Aryloxazole und ihre Verwendung
DE102007036076A1 (de) 2007-08-01 2009-02-05 Bayer Healthcare Aktiengesellschaft Dipeptoid-Produgs und ihre Verwendung
DE102007061764A1 (de) * 2007-12-20 2009-06-25 Bayer Healthcare Ag Anellierte Cyanopyridine und ihre Verwendung
DE102007061763A1 (de) * 2007-12-20 2009-06-25 Bayer Healthcare Ag Substituierte azabicyclische Verbindungen und ihre Verwendung
DE102008013587A1 (de) * 2008-03-11 2009-09-17 Bayer Schering Pharma Aktiengesellschaft Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung
CL2009001152A1 (es) 2008-05-13 2009-10-16 Array Biopharma Inc Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa.
ES2428818T3 (es) * 2008-05-29 2013-11-11 Bayer Intellectual Property Gmbh Dicianopiridinas sustituidas con 2-alcoxi y su uso
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
DE102008062567A1 (de) 2008-12-16 2010-06-17 Bayer Schering Pharma Aktiengesellschaft Dipeptoid-Prodrugs und ihre Verwendung
DE102009006602A1 (de) * 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
DE102010030688A1 (de) 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
US20120058983A1 (en) 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
KR20140059164A (ko) 2011-03-15 2014-05-15 트라이우스 테라퓨틱스, 아이엔씨. 트라이사이클릭 자이라제 억제제
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
EP2968439A2 (de) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Zusammensetzungen zur behandlung von magen-darm-störungen
EP2984086A1 (de) 2013-04-11 2016-02-17 F. Hoffmann-La Roche AG Bace1-hemmer
RS56313B1 (sr) * 2013-05-02 2017-12-29 Hoffmann La Roche Derivati pirolo[2,3-d]pirimidina kao agonisti cb2 receptora
CN114829362A (zh) * 2019-12-10 2022-07-29 成都倍特药业股份有限公司 一种可用作shp2抑制剂的含氮杂原子的六元并五元芳环衍生物
CN114646700B (zh) * 2022-03-01 2023-10-20 浙江国邦药业有限公司 一种（s）-吡咯烷-2-甲腈盐酸盐的检测方法

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KR19990067704A (ko) 1992-12-17 1999-08-25 디. 제이. 우드, 스피겔 알렌 제이 부신피질자극호르몬 유리인자 길항제로서의 피롤로피리미딘을함유하는 약학 조성물
US5646152A (en) 1994-06-15 1997-07-08 Pfizer Inc. Methods of administering CRF antagonists
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EP0976745B1 (de) * 1997-03-26 2003-08-13 Taisho Pharmaceutical Co., Ltd 4-tetrahydropyridylpyrimidin-derivate
ES2239592T3 (es) 1999-03-11 2005-10-01 Taisho Pharmaceutical Co., Ltd Derivados de carbamoil tetrahidropirina.
AR028782A1 (es) 2000-07-05 2003-05-21 Taisho Pharmaceutical Co Ltd Derivados heterociclicos tetrahidropiridino o piperidino
JP4766393B2 (ja) * 2004-01-06 2011-09-07 大正製薬株式会社 トリアザ−シクロペンタ［ｃｄ］インデン誘導体

Also Published As

Publication number Publication date
AR042667A1 (es) 2005-06-29
US20080287397A1 (en) 2008-11-20
ES2325596T3 (es) 2009-09-09
EP1467997B1 (de) 2008-03-26
CA2485556C (en) 2006-01-10
TWI270549B (en) 2007-01-11
EP1467997A1 (de) 2004-10-20
CA2485556A1 (en) 2004-07-15
JP4181126B2 (ja) 2008-11-12
JP2005539090A (ja) 2005-12-22
ZA200405982B (en) 2005-09-02
US7932259B2 (en) 2011-04-26
ATE430151T1 (de) 2009-05-15
KR20060128063A (ko) 2006-12-13
EP1787992A1 (de) 2007-05-23
PL371810A1 (en) 2005-06-27
AU2003292550B2 (en) 2006-09-21
KR100688395B1 (ko) 2007-03-02
DE60327477D1 (de) 2009-06-10
WO2004058767A1 (en) 2004-07-15
US8455511B2 (en) 2013-06-04
UA77265C2 (en) 2006-11-15
KR100808756B1 (ko) 2008-02-29
ES2302949T3 (es) 2008-08-01
HRP20040724A2 (en) 2004-10-31
US20050209253A1 (en) 2005-09-22
AU2003292550A1 (en) 2004-07-22
EP1467997B8 (de) 2008-08-27
TW200505921A (en) 2005-02-16
EP1787992B1 (de) 2009-04-29
KR20040111369A (ko) 2004-12-31
MXPA04008081A (es) 2004-11-26
EA200401060A1 (ru) 2005-02-24
CN1692115A (zh) 2005-11-02
BR0307587A (pt) 2005-02-01
MY141200A (en) 2010-03-31
CL2003002762A1 (es) 2005-04-08
DE60319951T2 (de) 2009-05-20
AU2003292550B8 (en) 2006-11-09
ATE390426T1 (de) 2008-04-15
NO20043508L (no) 2004-10-07
US20110130364A1 (en) 2011-06-02

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: NAKAZATO, ATSURO, TOKYO 170-8633, JP

Inventor name: OKUBO, TAKETOSHI, TOKYO 170-8633, JP

Inventor name: NOZAWA, DAI, TOKYO 170-8633, JP

Inventor name: YAMAGUCHI, MIKAKO, TOKYO 170-8633, JP

Inventor name: TAMITA, TOMOKO, TOKYO 170-8633, JP

Inventor name: KENNIS, LUDO E.J., 2340 BEERSE, BE

Inventor name: DE BRUYN, MARCEL F. L., 2340 BEERSE, BE

Inventor name: BONGARTZ, JEAN-PIERRE A. M., 2340 BEERSE, BE

Inventor name: VAN DEN KEYBUS, FRANS M. A., 2340 BEERSE, BE

Inventor name: VAN ROOSBROECK, YVES E. M., 2340 BEERSE, BE

Inventor name: LUYCKX, MARCEL G. M., 2340 BEERSE, BE

Inventor name: HENDRICKX, ROBERT J. M., 2340 BEERSE, BE

8364 No opposition during term of opposition