BR0307587A - Derivado de pirroloprimida ou porrolopiridina substituìdo com um grupo amino cìclico, compostos, antagonista para receptores de crf, e, uso de um derivado de pirroloprimidina ou derivado de pirrolopiridina substituìdo com um grupo amino cìclico, um sal farmaceuticamente aceitável do mesmo ou seu hidrato - Google Patents

Derivado de pirroloprimida ou porrolopiridina substituìdo com um grupo amino cìclico, compostos, antagonista para receptores de crf, e, uso de um derivado de pirroloprimidina ou derivado de pirrolopiridina substituìdo com um grupo amino cìclico, um sal farmaceuticamente aceitável do mesmo ou seu hidrato

Info

Publication number
BR0307587A
BR0307587A BR0307587-7A BR0307587A BR0307587A BR 0307587 A BR0307587 A BR 0307587A BR 0307587 A BR0307587 A BR 0307587A BR 0307587 A BR0307587 A BR 0307587A
Authority
BR
Brazil
Prior art keywords
derivative
crf
derivative substituted
amino group
receptor antagonist
Prior art date
Application number
BR0307587-7A
Other languages
English (en)
Inventor
Atsuro Nakazato
Taketoshi Okubo
Dai Nozawa
Mikako Yamaguchi
Tomoko Tamita
Ludo E J Kennis
Marcel F L De Bruyn
Jean-Pierre A M Bongartz
Frans M A Van Den Keybus
Yves E M Van Roosbroeck
Marcel G M Luyckx
Robert J M Hendickx
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of BR0307587A publication Critical patent/BR0307587A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Biochemistry (AREA)
  • Addiction (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

"DERIVADO DE PIRROLOPIRIMIDINA OU PIRROLOPIRIDINA SUBSTITUìDO COM UM GRUPO AMINO CìCLICO, COMPOSTOS, ANTAGONISTA PARA RECEPTORES DE CRF, E, USO DE UM DERIVADO DE PIRROLOPIRIMIDINA OU DERIVADO DE PIRROLOPIRIDINA SUBSTITUìDO COM UM GRUPO AMINO CìCLICO UM SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO OU SEU HIDRATO". Um objeto da presente invenção consiste em proporcionar um antagonista contra receptores de CRF que é efetivo como um agente terapêutico ou profilático para doenças em que se considera que CRF está envolvido, como depressão, ansiedade, doença de Alzheimer, doença de Parkinson, coréia de Huntington, distúrbio alimentar, hipertensão, doenças gástricas, dependência de drogas, epilepsia, infarto cerebral, isquemia cerebral, edema cerebral, lesão cefálica externa, inflamação, doenças relacionadas com imunidade, alopecia, síndrome do intestino irritável, transtornos do sono, epilepsia, dermatites, esquizofrenia, etc. Um derivado de pirrolopirimidina ou pirrolopiridina substituído com um grupo amino cíclico representado pela fórmula [I]: a seguir: apresenta uma alta afinidade por receptores de CRF e é efetivo contra doenças em que se considera que CRF está envolvido.
BR0307587-7A 2002-12-26 2003-12-24 Derivado de pirroloprimida ou porrolopiridina substituìdo com um grupo amino cìclico, compostos, antagonista para receptores de crf, e, uso de um derivado de pirroloprimidina ou derivado de pirrolopiridina substituìdo com um grupo amino cìclico, um sal farmaceuticamente aceitável do mesmo ou seu hidrato BR0307587A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002383667 2002-12-26
PCT/JP2003/016598 WO2004058767A1 (en) 2002-12-26 2003-12-24 Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group

Publications (1)

Publication Number Publication Date
BR0307587A true BR0307587A (pt) 2005-02-01

Family

ID=32677471

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307587-7A BR0307587A (pt) 2002-12-26 2003-12-24 Derivado de pirroloprimida ou porrolopiridina substituìdo com um grupo amino cìclico, compostos, antagonista para receptores de crf, e, uso de um derivado de pirroloprimidina ou derivado de pirrolopiridina substituìdo com um grupo amino cìclico, um sal farmaceuticamente aceitável do mesmo ou seu hidrato

Country Status (23)

Country Link
US (3) US20050209253A1 (pt)
EP (2) EP1787992B1 (pt)
JP (1) JP4181126B2 (pt)
KR (2) KR100688395B1 (pt)
CN (1) CN1692115A (pt)
AR (1) AR042667A1 (pt)
AT (2) ATE430151T1 (pt)
AU (1) AU2003292550B8 (pt)
BR (1) BR0307587A (pt)
CA (1) CA2485556C (pt)
CL (1) CL2003002762A1 (pt)
DE (2) DE60319951T2 (pt)
EA (1) EA200401060A1 (pt)
ES (2) ES2325596T3 (pt)
HR (1) HRP20040724A2 (pt)
MX (1) MXPA04008081A (pt)
MY (1) MY141200A (pt)
NO (1) NO20043508L (pt)
PL (1) PL371810A1 (pt)
TW (1) TWI270549B (pt)
UA (1) UA77265C2 (pt)
WO (1) WO2004058767A1 (pt)
ZA (1) ZA200405982B (pt)

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CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
DE102008062567A1 (de) 2008-12-16 2010-06-17 Bayer Schering Pharma Aktiengesellschaft Dipeptoid-Prodrugs und ihre Verwendung
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DE102010030688A1 (de) 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
US20120058983A1 (en) 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
KR20140059164A (ko) 2011-03-15 2014-05-15 트라이우스 테라퓨틱스, 아이엔씨. 트라이사이클릭 자이라제 억제제
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Publication number Publication date
AU2003292550B8 (en) 2006-11-09
UA77265C2 (en) 2006-11-15
US8455511B2 (en) 2013-06-04
EP1787992B1 (en) 2009-04-29
AU2003292550B2 (en) 2006-09-21
DE60319951D1 (de) 2008-05-08
KR20060128063A (ko) 2006-12-13
ATE390426T1 (de) 2008-04-15
KR100688395B1 (ko) 2007-03-02
EA200401060A1 (ru) 2005-02-24
ES2325596T3 (es) 2009-09-09
JP4181126B2 (ja) 2008-11-12
TWI270549B (en) 2007-01-11
US7932259B2 (en) 2011-04-26
DE60319951T2 (de) 2009-05-20
ATE430151T1 (de) 2009-05-15
CA2485556C (en) 2006-01-10
JP2005539090A (ja) 2005-12-22
EP1467997A1 (en) 2004-10-20
EP1787992A1 (en) 2007-05-23
ZA200405982B (en) 2005-09-02
CA2485556A1 (en) 2004-07-15
MXPA04008081A (es) 2004-11-26
AU2003292550A1 (en) 2004-07-22
CL2003002762A1 (es) 2005-04-08
US20110130364A1 (en) 2011-06-02
HRP20040724A2 (en) 2004-10-31
KR100808756B1 (ko) 2008-02-29
US20080287397A1 (en) 2008-11-20
US20050209253A1 (en) 2005-09-22
PL371810A1 (en) 2005-06-27
CN1692115A (zh) 2005-11-02
WO2004058767A1 (en) 2004-07-15
AR042667A1 (es) 2005-06-29
TW200505921A (en) 2005-02-16
EP1467997B8 (en) 2008-08-27
EP1467997B1 (en) 2008-03-26
MY141200A (en) 2010-03-31
NO20043508L (no) 2004-10-07
ES2302949T3 (es) 2008-08-01
KR20040111369A (ko) 2004-12-31
DE60327477D1 (de) 2009-06-10

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