DK1537124T3 - C-substituerede, tricykliske isoxazolinderivater og deres anvendelse som antidepressive midler - Google Patents

C-substituerede, tricykliske isoxazolinderivater og deres anvendelse som antidepressive midler

Info

Publication number
DK1537124T3
DK1537124T3 DK03787817T DK03787817T DK1537124T3 DK 1537124 T3 DK1537124 T3 DK 1537124T3 DK 03787817 T DK03787817 T DK 03787817T DK 03787817 T DK03787817 T DK 03787817T DK 1537124 T3 DK1537124 T3 DK 1537124T3
Authority
DK
Denmark
Prior art keywords
antidepressants
substituted tricyclic
isoxazoline derivatives
tricyclic isoxazoline
derivatives
Prior art date
Application number
DK03787817T
Other languages
Danish (da)
English (en)
Inventor
Margaretha Henrica Mari Bakker
Antonius Adrianus Hendr Megens
Jose Ignacio Johnso Andres-Gil
Jose Manuel Bartolome-Nebreda
Rosa Maria Joh Alvarez-Escobar
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK1537124T3 publication Critical patent/DK1537124T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK03787817T 2002-08-12 2003-08-12 C-substituerede, tricykliske isoxazolinderivater og deres anvendelse som antidepressive midler DK1537124T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02078322 2002-08-12
PCT/EP2003/050374 WO2004016621A1 (en) 2002-08-12 2003-08-12 C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants

Publications (1)

Publication Number Publication Date
DK1537124T3 true DK1537124T3 (da) 2007-10-29

Family

ID=31725449

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03787817T DK1537124T3 (da) 2002-08-12 2003-08-12 C-substituerede, tricykliske isoxazolinderivater og deres anvendelse som antidepressive midler

Country Status (15)

Country Link
US (1) US7465741B2 (de)
EP (1) EP1537124B1 (de)
JP (1) JP4681295B2 (de)
CN (1) CN1329396C (de)
AR (1) AR040967A1 (de)
AT (1) ATE368669T1 (de)
AU (1) AU2003262571B2 (de)
CA (1) CA2494235C (de)
DE (1) DE60315311T2 (de)
DK (1) DK1537124T3 (de)
ES (1) ES2290537T3 (de)
HK (1) HK1080080A1 (de)
PT (1) PT1537124E (de)
TW (1) TW200409777A (de)
WO (1) WO2004016621A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7265103B2 (en) * 2002-04-02 2007-09-04 Janssen Pharmaceutica Nv. Substituted amino isoxazoline derivatives and their use as anti-depressants
JP2008521771A (ja) 2004-11-26 2008-06-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 改良された抗精神病活性および抗不安症活性を有するイソキサゾリン−インドール誘導体
CN102786515B (zh) * 2012-04-13 2014-07-23 湖南大学 2-（2,2-二甲基-2,3-二氢苯并呋喃-5-基）吗啉及其制备方法与应用
CN112374984A (zh) * 2020-11-06 2021-02-19 苏州求索生物科技有限公司 一种2-溴-4-羟基苯甲醚的制备工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2055011T3 (es) * 1988-09-19 1994-08-16 Akzo Nv Un procedimiento para la preparacion de derivados de tetrahidronaftaleno e indano.
GB9318691D0 (en) * 1993-09-09 1993-10-27 Merck Sharp & Dohme Therapeutic agents
EP0724572B1 (de) * 1993-09-15 1998-12-16 MERCK SHARP & DOHME LTD. Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor-subtyps
KR100366962B1 (ko) * 1993-12-24 2003-03-03 산토리 가부시키가이샤 벤조티아진유도체
WO1997025317A1 (en) * 1996-01-05 1997-07-17 Hoechst Marion Roussel, Inc. 4,5-dihydronaphth[1,2-c]isoxazoles and derivatives thereof having cns activity
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
JP3531169B2 (ja) * 1996-06-11 2004-05-24 三菱ウェルファーマ株式会社 縮合ヘテロ環化合物およびその医薬用途
NZ508506A (en) * 1998-06-19 2004-01-30 H 4,5,6 and 7-indole and indoline derivatives, their preparation and use
KR100848898B1 (ko) * 2001-02-21 2008-07-29 얀센 파마슈티카 엔.브이. 항우울제로서 이속사졸린 유도체
US7265103B2 (en) 2002-04-02 2007-09-04 Janssen Pharmaceutica Nv. Substituted amino isoxazoline derivatives and their use as anti-depressants
DE60319388T2 (de) * 2002-08-21 2009-02-19 Janssen Pharmaceutica N.V. C6- und C9-substituierte Chromeno[4,3-c]Isoxazoline und ihre Verwendung als Anti-Depressiva

Also Published As

Publication number Publication date
TW200409777A (en) 2004-06-16
ATE368669T1 (de) 2007-08-15
AU2003262571A1 (en) 2004-03-03
US20050256119A1 (en) 2005-11-17
CN1329396C (zh) 2007-08-01
CA2494235C (en) 2011-10-11
CN1675222A (zh) 2005-09-28
AR040967A1 (es) 2005-04-27
JP4681295B2 (ja) 2011-05-11
ES2290537T3 (es) 2008-02-16
JP2005537304A (ja) 2005-12-08
US7465741B2 (en) 2008-12-16
WO2004016621A1 (en) 2004-02-26
HK1080080A1 (zh) 2006-04-21
PT1537124E (pt) 2007-10-16
DE60315311T2 (de) 2008-04-17
EP1537124B1 (de) 2007-08-01
DE60315311D1 (de) 2007-09-13
EP1537124A1 (de) 2005-06-08
AU2003262571B2 (en) 2009-02-12
CA2494235A1 (en) 2004-02-26

Similar Documents

Publication Publication Date Title
NO20053215D0 (no) Pyrazolderivater med anvendelse som COX-1-inhibitorer.
DK1789401T3 (da) Isoxazolinderivater og deres anvendelse som herbicider
DK1500654T3 (da) Benzoxazinonderivater, fremstilling deraf og anvendelse deraf som lægemidler
DK1425014T3 (da) Diarylcycloalkylderivater, fremgangsmåde til deres fremstilling og deres anvendelse som PPAR-aktivatorer
NO20054905D0 (no) 2-acylamino-4-fenyltiazolderivater, fremgangsmate for deres fremstilling og anvendelse av de samme som i terapeutika
DK1670458T3 (da) 1-Amino-2-oxy-substituerede tetrahydronaphthalenderivater, fremgangsmåder til fremstilling deraf og deres anvendelse som antiphlogistika
NO20035298D0 (no) CDK-inhiberende pyrimider, deres fremstilling og deres anvendelse som legemidler
NO20052995D0 (no) 1,5-diaryl-pyrrol-3-karboksamid-derivater, og deres anvendelse som kannabinoid reseptormodulatorer.
NO20053356D0 (no) Aminindazolderivater og anvendelse derav som kinaseinhibitorer.
NO20071095L (no) Hittil ukjente tiofenderivater
DK1948149T4 (da) Formulering, som omfatter metformin og vildagliptin
DK1478629T3 (da) N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler
DK1592457T3 (da) Folat-vinblastin-konjugat som lægemiddel
NO20043950L (no) 3-cyklyl -5-(nitrogenholdig 5-leddet ring) metyl-oksazolidinon-derivater og deres anvendelse som antibakterielle midler
DK1368349T3 (da) Xanthinderivater, deres fremstilling og deres anvendelse som lægemidler
NO20053144D0 (no) Chk-, Pdk- og Akt-inhibitorpyrimidiner, deres fremstilling og anvendelse som famasoytiske midler.
DK1638928T3 (da) N-alkynyl-2-(substituerede aryloxy)alkylthio-amidderivater som fungicider
DK1562946T5 (da) Nye xanthinderivater, deres fremstilling og deres anvendelse som lægemiddel
NO20050665L (no) Pyrrolidonderivater som MAOE inhibitoere
NO20053775D0 (no) Diazepinoindol derivater som kinaseinhibitorer.
DK1633365T3 (da) Makrocykliske quinazolinderivater som antiproliferative midler
NO20053569D0 (no) Substituerte 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazinderivater og deres anvendelse som nevrokininantagonister
DK1753725T3 (da) Tetra-hydro-iso-quinolinsulfonamidderivater, fremstilling og terapeutisk anvendelse heraf.
DK1506179T3 (da) Benzoxazinderivater som 5-HT6-modulatorer og anvendelser deraf
DK1585742T3 (da) Substituerede benzoylderivater som herbicider