ES2055011T3 - Un procedimiento para la preparacion de derivados de tetrahidronaftaleno e indano. - Google Patents
Un procedimiento para la preparacion de derivados de tetrahidronaftaleno e indano.Info
- Publication number
- ES2055011T3 ES2055011T3 ES89202291T ES89202291T ES2055011T3 ES 2055011 T3 ES2055011 T3 ES 2055011T3 ES 89202291 T ES89202291 T ES 89202291T ES 89202291 T ES89202291 T ES 89202291T ES 2055011 T3 ES2055011 T3 ES 2055011T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- substituted
- tetrahidronaftaleno
- derivatives
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
LA INVENCION ES RELATIVA A DERIVADOS DE TETRAHIDRONAFTALENO E INDALO CON LA FORMULA GENERAL I: EN DONDE R1 REPRESENTA DE CEO A CUATRO SUBSTITUYENTES, LOS CUALES PUEDEN SER LOS MISMOS O DIFERENTES Y SE SELECCIONAN DE ENTRE OH, HALOGENO, NO2, CN, CF3, C1-C4 ALQUILO, C1-C4 ALCOXILO Y AMINO NO SUBSTITUIDO O C1-C4 ALQUILO SUBSTITUIDO; R2 REPRESENTA C1-C4 ALQUILO, C1-C4 ALQUENILO O C1-C4 ALQUINILO, EL CUAL PUEDE ESTAR SUBSTITUIDO POR HALOGENO; R3 Y R4 REPRESENTAN INDEPENDIENTEMENTE H, C1-C4 ALQUILO O FORMAN JUNTO CON EL ATOMO DE NITROGENO UN ANILLO DE 5 O 6 MIEMBROS; N TIENE EL VALOR 0 O 1; ALK ES UN HIDROCARBURO ALIFATICO CON 1-8 ATOMOS DE CARBONO Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. ESTOS NUEVOS COMPUESTOS SON TIPICOS BLOQUEADORES DE MONOAMIDAS REUBICADAS CON ADICIONAL ACTIVIDAD ANTAGONICA (ALFA)2 Y MUESTRAN FUERTE ACTIVIDAD ANTIDEPRESIVA SIN SER SEDANTES. LOS COMPUESTOS DE ACUERDO A ESTA INVENCION TAMBIEN SON UTILES PARA TRATAR PACIENTES CON DESORDENES DE ANSIEDAD, P.EJ. PANICO DESORDENADO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP88308640 | 1988-09-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2055011T3 true ES2055011T3 (es) | 1994-08-16 |
Family
ID=8200216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89202291T Expired - Lifetime ES2055011T3 (es) | 1988-09-19 | 1989-09-08 | Un procedimiento para la preparacion de derivados de tetrahidronaftaleno e indano. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4980354A (es) |
EP (1) | EP0361577B1 (es) |
JP (1) | JPH02134347A (es) |
AU (1) | AU619344B2 (es) |
CA (1) | CA1325011C (es) |
DE (1) | DE68906340T2 (es) |
DK (1) | DK459589A (es) |
ES (1) | ES2055011T3 (es) |
FI (1) | FI894402A (es) |
IE (1) | IE892905L (es) |
NZ (1) | NZ230674A (es) |
PT (1) | PT91743B (es) |
ZA (1) | ZA896996B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2633617B1 (fr) * | 1988-07-04 | 1991-02-08 | Adir | Nouveaux derives du benzocycloheptene, leur procede de preparation et les compositions pharmaceutiques les renfermant |
US5457100A (en) * | 1991-12-02 | 1995-10-10 | Daniel; David G. | Method for treatment of recurrent paroxysmal neuropsychiatric |
CA2147075A1 (en) * | 1994-04-28 | 1995-10-29 | Genesis Group Inc. | Chromotropic acid-formaldehyde and 1-naphthol-formaldehyde polymeric compounds |
DE19604191A1 (de) * | 1996-02-06 | 1997-08-07 | Hoechst Schering Agrevo Gmbh | 2,4-Diamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
SK11612003A3 (sk) * | 2001-02-21 | 2004-04-06 | Janssen Pharmaceutica N. V. | Izoxazolínové deriváty ako antidepresívne činidlá |
EP1492796B1 (en) | 2002-04-02 | 2007-09-05 | Janssen Pharmaceutica N.V. | Substituted amino isoxazoline derivatives and their use as anti-depressants. |
AR040967A1 (es) * | 2002-08-12 | 2005-04-27 | Janssen Pharmaceutica Nv | Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos |
EP1554286B1 (en) * | 2002-08-15 | 2010-01-27 | Janssen Pharmaceutica N.V. | Fused heterocyclic isoxazoline derivatives and their use as anti-depressants |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1139135A (en) * | 1965-10-01 | 1969-01-08 | Kefalas As | Aminoalkyl-substituted indanes and pharmaceutical compositions containing them |
BE786748A (fr) * | 1971-07-26 | 1973-01-26 | Basf Ag | 1-aminomethyl-indanes-n-substitues |
US4505932A (en) * | 1983-05-13 | 1985-03-19 | Abbott Laboratories | Method of producing α2 -adrenergic receptor agonist activity |
DE3630903A1 (de) * | 1986-09-11 | 1988-03-24 | Thomae Gmbh Dr K | Neue tetrahydronaphthalin- und indanderivate, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
-
1989
- 1989-09-08 DE DE8989202291T patent/DE68906340T2/de not_active Expired - Fee Related
- 1989-09-08 EP EP89202291A patent/EP0361577B1/en not_active Expired - Lifetime
- 1989-09-08 ES ES89202291T patent/ES2055011T3/es not_active Expired - Lifetime
- 1989-09-11 CA CA000610916A patent/CA1325011C/en not_active Expired - Fee Related
- 1989-09-11 IE IE892905A patent/IE892905L/xx unknown
- 1989-09-13 ZA ZA896996A patent/ZA896996B/xx unknown
- 1989-09-14 US US07/408,171 patent/US4980354A/en not_active Expired - Fee Related
- 1989-09-15 NZ NZ230674A patent/NZ230674A/en unknown
- 1989-09-18 FI FI894402A patent/FI894402A/fi not_active Application Discontinuation
- 1989-09-18 DK DK459589A patent/DK459589A/da not_active Application Discontinuation
- 1989-09-18 JP JP1241657A patent/JPH02134347A/ja active Pending
- 1989-09-18 PT PT91743A patent/PT91743B/pt not_active IP Right Cessation
- 1989-09-19 AU AU41552/89A patent/AU619344B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
PT91743A (pt) | 1990-03-30 |
AU619344B2 (en) | 1992-01-23 |
CA1325011C (en) | 1993-12-07 |
AU4155289A (en) | 1990-03-22 |
JPH02134347A (ja) | 1990-05-23 |
DE68906340T2 (de) | 1993-08-12 |
NZ230674A (en) | 1991-03-26 |
FI894402A (fi) | 1990-03-20 |
EP0361577B1 (en) | 1993-05-05 |
DK459589A (da) | 1990-03-20 |
PT91743B (pt) | 1995-05-31 |
IE892905L (en) | 1990-03-19 |
FI894402A0 (fi) | 1989-09-18 |
EP0361577A1 (en) | 1990-04-04 |
DK459589D0 (da) | 1989-09-18 |
DE68906340D1 (de) | 1993-06-09 |
ZA896996B (en) | 1990-06-27 |
US4980354A (en) | 1990-12-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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