AR007088A1 - 2,4-diaminopirimidinas sustituidas, compuestos intermedios utilizados en su preparacion, procedimiento para la preparacion de dichas 2,4-diaminopirimidinas sustituidas, medicamentos que las contienen y empleos de dichas pirimidinas - Google Patents

2,4-diaminopirimidinas sustituidas, compuestos intermedios utilizados en su preparacion, procedimiento para la preparacion de dichas 2,4-diaminopirimidinas sustituidas, medicamentos que las contienen y empleos de dichas pirimidinas

Info

Publication number
AR007088A1
AR007088A1 ARP970101966A ARP970101966A AR007088A1 AR 007088 A1 AR007088 A1 AR 007088A1 AR P970101966 A ARP970101966 A AR P970101966A AR P970101966 A ARP970101966 A AR P970101966A AR 007088 A1 AR007088 A1 AR 007088A1
Authority
AR
Argentina
Prior art keywords
preparation
diaminopyrimidines
substituted
pirimidines
employments
Prior art date
Application number
ARP970101966A
Other languages
English (en)
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of AR007088A1 publication Critical patent/AR007088A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

2,4-diaminopirimidinas sustituidas de la fórmula general (I) en donde R1 es alcoxilo inferior, R2 es bromo alcoxilo inferior o hidroxilo, R3 es hidrógeno,alquilo inferior, cicloalquilo, arilo, heteroalrilo, aralquilo, heteroaralquilo o ciano, R4 yR5 son cada uno independientemente, hidrógeno, alquilo inferior,alcoxilo inferior, halógeno, hidroxilo, amino, di(alquilo inferior)-amino, ciano o nitro y Q es etinileno o vinileno, sus sales farmacéuticamente utilizables,el empleo de estoscompuestos y sus sales como sustancias terapéuticamente activas; medicamentos a base de estas sustancias y su producción; el empleo deestas sustancias como medicamentos y para la producción de medicamentos antibacterialmente-activos;así como la pr eparación de los compuestos defórmula I y sus sales farmacéuticamente aceptables e intermdios para su preparación.
ARP970101966A 1996-05-15 1997-05-12 2,4-diaminopirimidinas sustituidas, compuestos intermedios utilizados en su preparacion, procedimiento para la preparacion de dichas 2,4-diaminopirimidinas sustituidas, medicamentos que las contienen y empleos de dichas pirimidinas AR007088A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96107739 1996-05-15

Publications (1)

Publication Number Publication Date
AR007088A1 true AR007088A1 (es) 1999-10-13

Family

ID=8222784

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101966A AR007088A1 (es) 1996-05-15 1997-05-12 2,4-diaminopirimidinas sustituidas, compuestos intermedios utilizados en su preparacion, procedimiento para la preparacion de dichas 2,4-diaminopirimidinas sustituidas, medicamentos que las contienen y empleos de dichas pirimidinas

Country Status (29)

Country Link
US (1) US5866583A (es)
EP (1) EP0901488B1 (es)
JP (1) JP3098259B2 (es)
KR (1) KR100295509B1 (es)
CN (1) CN1098260C (es)
AR (1) AR007088A1 (es)
AT (1) ATE227282T1 (es)
AU (1) AU726416B2 (es)
BR (1) BR9709251A (es)
CA (1) CA2254117C (es)
CO (1) CO4840509A1 (es)
CY (1) CY2425B1 (es)
CZ (1) CZ364698A3 (es)
DE (1) DE69716901T2 (es)
DK (1) DK0901488T3 (es)
ES (1) ES2184089T3 (es)
HR (1) HRP970260A2 (es)
IL (1) IL126702A0 (es)
MA (1) MA24182A1 (es)
NO (1) NO985335L (es)
NZ (1) NZ332481A (es)
PE (1) PE78898A1 (es)
PL (1) PL330277A1 (es)
PT (1) PT901488E (es)
TR (1) TR199802331T2 (es)
TW (1) TW438796B (es)
WO (1) WO1997043277A1 (es)
YU (1) YU51498A (es)
ZA (1) ZA973984B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0966464B1 (en) * 1997-03-03 2003-05-28 Basilea Pharmaceutica AG Substituted 2,4-diaminopyrimidines
PT966464E (pt) * 1997-03-03 2003-09-30 Basilea Pharmaceutica Ag 2,4-diaminopirimidinas substituidas
US6277860B1 (en) * 1999-10-29 2001-08-21 Pfizer Inc Furopyridine antibacterials
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
CA2528834A1 (en) * 2003-06-13 2005-02-10 Arena Pharmaceuticals, Inc. 5-substituted 2h-pyrazole-3-carboxylic acid derivatives as agonists for the nicotinic acid receptor rup25 for the treatment of dyslipidemia and related diseases
US7659408B2 (en) * 2003-08-07 2010-02-09 Merck Sharp & Dhome Corp. Pyrazole carboxamides as inhibitors of 11-β-hydroxysteroid dehydrogenase-1
WO2005016278A2 (en) 2003-08-12 2005-02-24 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
DE102005062987A1 (de) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln
CN101784515A (zh) * 2007-08-03 2010-07-21 弗·哈夫曼-拉罗切有限公司 作为taar1配体的吡啶甲酰胺和苯甲酰胺衍生物
CA2741511C (en) * 2008-11-21 2017-01-24 Raqualia Pharma Inc. Novel pyrazole-3-carboxamide derivative having 5-ht2b receptor antagonist activity
WO2010084152A1 (en) * 2009-01-21 2010-07-29 Basilea Pharmaceutica Ag Novel bicyclic antibiotics
JP5753856B2 (ja) * 2009-12-15 2015-07-22 バイエル・クロップサイエンス・アーゲーＢａｙｅｒ Ｃｒｏｐｓｃｉｅｎｃｅ Ａｇ １−アルキル−／１−アリール−５−ピラゾールカルボン酸誘導体を調製する方法
GEP20156417B (en) 2011-04-05 2015-12-25 Pfizer Ltd Pyrrolo [2,3-d] pyrimidine derivatives as inhibitors of tropomyosin-related kinases
DE102013208484B4 (de) 2013-05-08 2018-04-26 Wirtgen Gmbh Vorrichtung zum Bearbeiten von Straßen- oder Bodenoberflächen, sowie Verfahren zum Lenken einer Straßenfräsmaschine
AR117169A1 (es) * 2018-11-28 2021-07-14 Bayer Ag (tio)amidas de piridazina como compuestos fungicidas

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
US4013644A (en) * 1976-03-15 1977-03-22 G. D. Searle & Co. [8 α(E), 13aβ]-5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-8-(2-phenylethenyl)-6H-dibenzo[a,g]quinolizines and intermediates thereto
US4444770A (en) * 1980-05-29 1984-04-24 Bayer Aktiengesellschaft New imidazoazole-alkenoic acid amide compounds, intermediate products for their production, their production, and their medicinal use
US4594199A (en) * 1983-09-19 1986-06-10 E. R. Squibb & Sons, Inc. Method for making phosphinic acid intermediates
PT99514B (pt) * 1990-11-14 1999-04-30 Chiron Corp Processo de preparacao de compostos para o tratamento de infeccoes fungicas
BR9509768A (pt) * 1994-11-24 1998-07-07 Hoffmann La Roche Novas pirimidinas de benzila
WO1996040640A1 (en) * 1995-06-07 1996-12-19 Pfizer Inc. BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION
EP0866791B1 (en) * 1995-12-04 2002-01-30 Arpida AG, Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial

Also Published As

Publication number Publication date
CZ364698A3 (cs) 1999-02-17
JP3098259B2 (ja) 2000-10-16
DE69716901D1 (de) 2002-12-12
CA2254117A1 (en) 1997-11-20
DE69716901T2 (de) 2003-09-18
CN1098260C (zh) 2003-01-08
TW438796B (en) 2001-06-07
CN1218465A (zh) 1999-06-02
YU51498A (en) 1999-11-22
CO4840509A1 (es) 1999-09-27
PE78898A1 (es) 1998-11-13
AU726416B2 (en) 2000-11-09
CY2425B1 (en) 2004-11-12
BR9709251A (pt) 1999-08-10
AU2894297A (en) 1997-12-05
NO985335D0 (no) 1998-11-16
PL330277A1 (en) 1999-05-10
CA2254117C (en) 2003-03-11
NO985335L (no) 1999-01-15
NZ332481A (en) 2000-04-28
ES2184089T3 (es) 2003-04-01
ZA973984B (en) 1997-11-17
WO1997043277A1 (en) 1997-11-20
EP0901488B1 (en) 2002-11-06
ATE227282T1 (de) 2002-11-15
EP0901488A1 (en) 1999-03-17
MA24182A1 (fr) 1997-12-31
HRP970260A2 (en) 1998-04-30
PT901488E (pt) 2003-03-31
TR199802331T2 (xx) 1999-04-21
IL126702A0 (en) 1999-08-17
DK0901488T3 (da) 2003-03-03
KR100295509B1 (ko) 2001-09-17
US5866583A (en) 1999-02-02
JPH11511749A (ja) 1999-10-12
KR20000011053A (ko) 2000-02-25

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