GT199800179A - Procedimiento de sintesis de pirrol amidas. - Google Patents

Procedimiento de sintesis de pirrol amidas.

Info

Publication number
GT199800179A
GT199800179A GT199800179A GT199800179A GT199800179A GT 199800179 A GT199800179 A GT 199800179A GT 199800179 A GT199800179 A GT 199800179A GT 199800179 A GT199800179 A GT 199800179A GT 199800179 A GT199800179 A GT 199800179A
Authority
GT
Guatemala
Prior art keywords
compounds
pirrol
amidas
synthesis
synthesis procedure
Prior art date
Application number
GT199800179A
Other languages
English (en)
Inventor
John Antony Ragan
Teresa Woodall Makowski
David John Am Ende
Pamela Jane Clifford
Gregory Randall Young
Alyson Kay Conrad
Shane Allen Eisenbeis
Douglas John Meldrum Allen
George Joseph Quallich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199800179A publication Critical patent/GT199800179A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA SINTESIS DE NUEVAS PIRROLCARBOXAMIDAS CONDENSADAS QUE SE UNEN SELECTIVAMENTE A RECEPTORES GABAA. ESTA INVENCION TAMBIEN SE REFIERE A INTERMEDIOS QUIMICOS PARA LA SINTESIS DE TALES COMPUESTOS. LOS COMPUESTOS QUE SE UNEN A LOS RECEPTORES GABAA SON UTILES EN EL TRATAMIENTO DE LA ANSIEDAD, DE TRASTORNOS DEL SUEÑO Y CRISIS CONVULSIVAS Y DE SOBREDOSIS DE FARMACOS DE TIPO BENZODIACEPINA, Y PARA AUMENTAR EL ESTADO DE VIGILANCIA. ESTOS COMPUESTOS TIENEN LA ESTRUCTURA I, EN LA QUE R1, R2 Y AR, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE.
GT199800179A 1997-11-13 1998-11-09 Procedimiento de sintesis de pirrol amidas. GT199800179A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6542297P 1997-11-13 1997-11-13

Publications (1)

Publication Number Publication Date
GT199800179A true GT199800179A (es) 2000-05-02

Family

ID=22062607

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199800179A GT199800179A (es) 1997-11-13 1998-11-09 Procedimiento de sintesis de pirrol amidas.

Country Status (3)

Country Link
AP (1) AP948A (es)
GT (1) GT199800179A (es)
ZA (1) ZA9810350B (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
WO1997034870A1 (en) * 1996-03-22 1997-09-25 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands

Also Published As

Publication number Publication date
AP948A (en) 2001-03-15
AP9801391A0 (en) 1998-12-31
ZA9810350B (en) 2000-05-12

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