ES2156889T3 - Compuestos biciclicos antagonistas de receptores de aminoacidos excitativos. - Google Patents
Compuestos biciclicos antagonistas de receptores de aminoacidos excitativos.Info
- Publication number
- ES2156889T3 ES2156889T3 ES94307522T ES94307522T ES2156889T3 ES 2156889 T3 ES2156889 T3 ES 2156889T3 ES 94307522 T ES94307522 T ES 94307522T ES 94307522 T ES94307522 T ES 94307522T ES 2156889 T3 ES2156889 T3 ES 2156889T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acids
- excitative
- antagonist
- receivers
- bicycle compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000002964 excitative effect Effects 0.000 title 1
- 238000011282 treatment Methods 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Abstract
EN ESTA INVENCION SE PRESENTAN NUEVOS COMPUESTOS BICICLICOS DE LA FORMULA I EN LA QUE W, R1, R2, R3, N, M Y P REPRESENTAN LO INDICADO EN LA ESPECIFICACION, Y QUE SON UTILES COMO ANTAGONISTAS DEL RECEPTOR DE AMINOACIDOS EXCITANTES Y PARA EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS. EN ESTA INVENCION TAMBIEN SE PRESENTAN LOS INTERMEDIOS UTILES PARA LA SINTESIS DE LOS ANTAGONISTAS DE AMINOACIDOS EXCITANTES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/138,664 US5491241A (en) | 1993-10-18 | 1993-10-18 | Bicyclic intermediates for excitatory amino acid receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2156889T3 true ES2156889T3 (es) | 2001-08-01 |
Family
ID=22483074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94307522T Expired - Lifetime ES2156889T3 (es) | 1993-10-18 | 1994-10-13 | Compuestos biciclicos antagonistas de receptores de aminoacidos excitativos. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5491241A (es) |
EP (1) | EP0648762B1 (es) |
JP (1) | JPH07149724A (es) |
AT (1) | ATE201406T1 (es) |
CA (1) | CA2117852A1 (es) |
DE (1) | DE69427262T2 (es) |
DK (1) | DK0648762T3 (es) |
ES (1) | ES2156889T3 (es) |
GR (1) | GR3036429T3 (es) |
PT (1) | PT648762E (es) |
SI (1) | SI0648762T1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
US5824662A (en) * | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
AU733880B2 (en) | 1996-09-27 | 2001-05-31 | Eisai Inc. | Naaladase compositions and methods for treating glutamate abnormality and effecting neuronal activity in animals |
US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
CN101007789B (zh) * | 2006-01-27 | 2014-08-20 | 北京摩力克科技有限公司 | 取代五元氮杂环盐类化合物及其治疗蛋白老化相关疾病的用途 |
EP2029536B1 (en) | 2006-04-28 | 2013-08-28 | Laboratorios Del. Dr. Esteve, S.A. | Bicyclic tetrahydropyrrole compounds |
EP1849771A1 (en) * | 2006-04-28 | 2007-10-31 | Laboratorios Del Dr. Esteve, S.A. | Bicyclic tetrahydropyrrole compounds |
EP1849770A1 (en) * | 2006-04-28 | 2007-10-31 | Laboratorios Del Dr. Esteve, S.A. | Production process for bicyclic tetrahydropyrrole compounds |
EP1849772A1 (en) * | 2006-04-28 | 2007-10-31 | Laboratorios Del Dr. Esteve, S.A. | Bicyclic tetrahydropyrrole compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3322530A1 (de) * | 1983-06-23 | 1985-01-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren |
EP0331609A3 (de) * | 1988-01-27 | 1992-07-01 | Hoechst Aktiengesellschaft | Angiotensin-Converting-Enzym-Hemmstoffe mit psychotroper Wirkung |
US4902695A (en) * | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
SE9003652D0 (sv) * | 1990-11-15 | 1990-11-15 | Astra Ab | New heterocyclic compounds |
US5319095A (en) * | 1992-12-04 | 1994-06-07 | Eli Lilly And Company | Synthesis of kainic acid |
-
1993
- 1993-10-18 US US08/138,664 patent/US5491241A/en not_active Expired - Fee Related
-
1994
- 1994-10-11 CA CA002117852A patent/CA2117852A1/en not_active Abandoned
- 1994-10-12 JP JP6246171A patent/JPH07149724A/ja not_active Withdrawn
- 1994-10-13 EP EP94307522A patent/EP0648762B1/en not_active Expired - Lifetime
- 1994-10-13 DK DK94307522T patent/DK0648762T3/da active
- 1994-10-13 AT AT94307522T patent/ATE201406T1/de not_active IP Right Cessation
- 1994-10-13 SI SI9430377T patent/SI0648762T1/xx unknown
- 1994-10-13 PT PT94307522T patent/PT648762E/pt unknown
- 1994-10-13 ES ES94307522T patent/ES2156889T3/es not_active Expired - Lifetime
- 1994-10-13 DE DE69427262T patent/DE69427262T2/de not_active Expired - Fee Related
-
1995
- 1995-06-01 US US08/457,924 patent/US5641798A/en not_active Expired - Fee Related
-
2001
- 2001-08-20 GR GR20010401280T patent/GR3036429T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT648762E (pt) | 2001-08-30 |
US5641798A (en) | 1997-06-24 |
EP0648762A2 (en) | 1995-04-19 |
DE69427262D1 (de) | 2001-06-28 |
JPH07149724A (ja) | 1995-06-13 |
EP0648762A3 (en) | 1995-04-26 |
DK0648762T3 (da) | 2001-07-30 |
SI0648762T1 (en) | 2001-10-31 |
CA2117852A1 (en) | 1995-04-19 |
EP0648762B1 (en) | 2001-05-23 |
US5491241A (en) | 1996-02-13 |
GR3036429T3 (en) | 2001-11-30 |
DE69427262T2 (de) | 2001-10-31 |
ATE201406T1 (de) | 2001-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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