DK0648762T3 - Bicykliske forbindelser som excitatoriske aminosyrereceptorantagonister - Google Patents
Bicykliske forbindelser som excitatoriske aminosyrereceptorantagonisterInfo
- Publication number
- DK0648762T3 DK0648762T3 DK94307522T DK94307522T DK0648762T3 DK 0648762 T3 DK0648762 T3 DK 0648762T3 DK 94307522 T DK94307522 T DK 94307522T DK 94307522 T DK94307522 T DK 94307522T DK 0648762 T3 DK0648762 T3 DK 0648762T3
- Authority
- DK
- Denmark
- Prior art keywords
- amino acid
- excitatory amino
- receptor antagonists
- acid receptor
- bicyclic compounds
- Prior art date
Links
- 229940123511 Excitatory amino acid receptor antagonist Drugs 0.000 title abstract 2
- 125000002619 bicyclic group Chemical group 0.000 title abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 239000003194 amino acid receptor blocking agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/138,664 US5491241A (en) | 1993-10-18 | 1993-10-18 | Bicyclic intermediates for excitatory amino acid receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0648762T3 true DK0648762T3 (da) | 2001-07-30 |
Family
ID=22483074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94307522T DK0648762T3 (da) | 1993-10-18 | 1994-10-13 | Bicykliske forbindelser som excitatoriske aminosyrereceptorantagonister |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5491241A (da) |
| EP (1) | EP0648762B1 (da) |
| JP (1) | JPH07149724A (da) |
| AT (1) | ATE201406T1 (da) |
| CA (1) | CA2117852A1 (da) |
| DE (1) | DE69427262T2 (da) |
| DK (1) | DK0648762T3 (da) |
| ES (1) | ES2156889T3 (da) |
| GR (1) | GR3036429T3 (da) |
| PT (1) | PT648762E (da) |
| SI (1) | SI0648762T1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
| US5824662A (en) * | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
| CN1230889A (zh) | 1996-09-27 | 1999-10-06 | 吉尔福特药业有限公司 | NAALADase组合物和治疗谷氨酸异常及在动物中产生神经元活性的方法 |
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| CN101007789B (zh) * | 2006-01-27 | 2014-08-20 | 北京摩力克科技有限公司 | 取代五元氮杂环盐类化合物及其治疗蛋白老化相关疾病的用途 |
| EP1849770A1 (en) * | 2006-04-28 | 2007-10-31 | Laboratorios Del Dr. Esteve, S.A. | Production process for bicyclic tetrahydropyrrole compounds |
| EP1849772A1 (en) | 2006-04-28 | 2007-10-31 | Laboratorios Del Dr. Esteve, S.A. | Bicyclic tetrahydropyrrole compounds |
| EP1849771A1 (en) * | 2006-04-28 | 2007-10-31 | Laboratorios Del Dr. Esteve, S.A. | Bicyclic tetrahydropyrrole compounds |
| MX2008013477A (es) | 2006-04-28 | 2008-10-29 | Esteve Labor Dr | Compuestos biciclicos de tetrahidropirrol. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3322530A1 (de) * | 1983-06-23 | 1985-01-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren |
| EP0331609A3 (de) * | 1988-01-27 | 1992-07-01 | Hoechst Aktiengesellschaft | Angiotensin-Converting-Enzym-Hemmstoffe mit psychotroper Wirkung |
| US4902695A (en) * | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| SE9003652D0 (sv) * | 1990-11-15 | 1990-11-15 | Astra Ab | New heterocyclic compounds |
| US5319095A (en) * | 1992-12-04 | 1994-06-07 | Eli Lilly And Company | Synthesis of kainic acid |
-
1993
- 1993-10-18 US US08/138,664 patent/US5491241A/en not_active Expired - Fee Related
-
1994
- 1994-10-11 CA CA002117852A patent/CA2117852A1/en not_active Abandoned
- 1994-10-12 JP JP6246171A patent/JPH07149724A/ja not_active Withdrawn
- 1994-10-13 EP EP94307522A patent/EP0648762B1/en not_active Expired - Lifetime
- 1994-10-13 ES ES94307522T patent/ES2156889T3/es not_active Expired - Lifetime
- 1994-10-13 DK DK94307522T patent/DK0648762T3/da active
- 1994-10-13 PT PT94307522T patent/PT648762E/pt unknown
- 1994-10-13 AT AT94307522T patent/ATE201406T1/de not_active IP Right Cessation
- 1994-10-13 DE DE69427262T patent/DE69427262T2/de not_active Expired - Fee Related
- 1994-10-13 SI SI9430377T patent/SI0648762T1/xx unknown
-
1995
- 1995-06-01 US US08/457,924 patent/US5641798A/en not_active Expired - Fee Related
-
2001
- 2001-08-20 GR GR20010401280T patent/GR3036429T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5491241A (en) | 1996-02-13 |
| ES2156889T3 (es) | 2001-08-01 |
| PT648762E (pt) | 2001-08-30 |
| EP0648762A2 (en) | 1995-04-19 |
| GR3036429T3 (en) | 2001-11-30 |
| CA2117852A1 (en) | 1995-04-19 |
| EP0648762A3 (en) | 1995-04-26 |
| EP0648762B1 (en) | 2001-05-23 |
| DE69427262T2 (de) | 2001-10-31 |
| JPH07149724A (ja) | 1995-06-13 |
| DE69427262D1 (de) | 2001-06-28 |
| ATE201406T1 (de) | 2001-06-15 |
| SI0648762T1 (en) | 2001-10-31 |
| US5641798A (en) | 1997-06-24 |
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