ECSP077170A - Moduladores de receptores acetilcolina nicotinicos alfa 7 y sus usos terapeuticos - Google Patents

Moduladores de receptores acetilcolina nicotinicos alfa 7 y sus usos terapeuticos

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Publication number
ECSP077170A
ECSP077170A EC2007007170A ECSP077170A ECSP077170A EC SP077170 A ECSP077170 A EC SP077170A EC 2007007170 A EC2007007170 A EC 2007007170A EC SP077170 A ECSP077170 A EC SP077170A EC SP077170 A ECSP077170 A EC SP077170A
Authority
EC
Ecuador
Prior art keywords
acetilcoline
alfa
nicotinic
therapeutic uses
receiver modulators
Prior art date
Application number
EC2007007170A
Other languages
English (en)
Inventor
Giovanni Gaviraghi
Chiara Ghiron
Hendrick Bothmann
Renza Roncarati
Georg Christian Terstap-Penn
Original Assignee
Siena Biotech Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siena Biotech Spa filed Critical Siena Biotech Spa
Publication of ECSP077170A publication Critical patent/ECSP077170A/es

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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Abstract

La presente invención describe compuestos con actividad agonística nAChR a7, procedimientos para su preparación, composiciones farmacéuticas que comprenden los mismos y su uso para el tratamiento de trastornos neurológicos, psiquiátricos, cognitivos, inmunológicos e inflamatorios.
EC2007007170A 2004-07-20 2007-01-15 Moduladores de receptores acetilcolina nicotinicos alfa 7 y sus usos terapeuticos ECSP077170A (es)

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JP (1) JP2008506744A (es)
KR (1) KR20070047763A (es)
CN (1) CN101018774A (es)
AU (1) AU2005263592A1 (es)
BR (1) BRPI0511993A (es)
CA (1) CA2574237A1 (es)
EC (1) ECSP077170A (es)
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NI (1) NI200700010A (es)
NO (1) NO20070347L (es)
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ZA (1) ZA200700527B (es)

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ZA200700527B (en) 2008-08-27
WO2006008133A3 (en) 2006-03-23
CA2574237A1 (en) 2006-01-26
JP2008506744A (ja) 2008-03-06
IL180775A0 (en) 2007-06-03
BRPI0511993A (pt) 2008-01-22
AU2005263592A1 (en) 2006-01-26
KR20070047763A (ko) 2007-05-07
RU2007101685A (ru) 2008-08-27
US20080275028A1 (en) 2008-11-06
RU2403247C2 (ru) 2010-11-10
CN101018774A (zh) 2007-08-15
NO20070347L (no) 2007-01-18
WO2006008133A2 (en) 2006-01-26
NI200700010A (es) 2008-05-29
EP1778658A2 (en) 2007-05-02
MX2007000669A (es) 2007-05-23

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