PE20060457A1 - Derivados de difenil eter como antagonistas de los receptores 5ht2 - Google Patents

Derivados de difenil eter como antagonistas de los receptores 5ht2

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Publication number
PE20060457A1
PE20060457A1 PE2005001039A PE2005001039A PE20060457A1 PE 20060457 A1 PE20060457 A1 PE 20060457A1 PE 2005001039 A PE2005001039 A PE 2005001039A PE 2005001039 A PE2005001039 A PE 2005001039A PE 20060457 A1 PE20060457 A1 PE 20060457A1
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PE
Peru
Prior art keywords
alkyl
antagonists
diphenyl ether
receptors
ether derivatives
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PE2005001039A
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English (en)
Inventor
Michelle Marie Claffey
Anton Franz Josef Fliri
Randall James Gallaschun
Christopher John O'donnell
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Pfizer Prod Inc
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Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20060457A1 publication Critical patent/PE20060457A1/es

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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/275—Nitriles; Isonitriles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
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    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
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    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE DIFENIL ETER DE FORMULAS Ia, Ib Y Ic, DONDE X E Y SON O, O(CH2)n, S, N, ENTRE OTROS; R1, R2 Y R3 SON H O CH3; R4 ES H, F, Cl O CH3; R5 ES F, ALQUILO C1-C6, ENTRE OTROS; R6 ES H, CN, ALQUILO C1-C6, ENTRE OTROS; R7 ES H, F, ALQUILO C1-C6, ENTRE OTROS; R8 ES H, F, ALQUILO C1-C6, ENTRE OTROS; R9 ES H, CH3, OH, ENTRE OTROS; R10 ES H, F, ALQUILO C1-C6, ENTRE OTROS; R11 Y R12 SON H, OH, ALQUILO C1-C6, ENTRE OTROS; R13, R15, R16 Y R17 SON H O ALQUILO C1-C6; R14 ES H, CH3, OH, ENTRE OTROS; k ES 1 O 2; m, u Y v SON 0, 1 O 2; n, p, q, r, s Y t SON 0, 1, 2, 3, 4, 5 O 6; LA LINEA DE PUNTOS REPRESENTA UN DOBLE ENLACE OPCIONAL. SON COMPUESTOS PREFERIDOS: 3-(5-CLORO-4-FLUORO-2-METILAMINOMETILFENOXI)-2-METILFENOL; [4-BROMO-2-(3-METOXI-2-METILFENOXI)BENCIL]METILAMINA, 2-[3-(METOXI-2-METIFENOXI)-4-METIAMINOMETILFENIL]PROPAN-2-OL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A COMPOSICIONES FARMACEUTICAS. DICHOS COMPUESTOS SON LIGANDOS DE LOS RECEPTORES DE SEROTONINA 5HT, PARTICULARMENTE SON ANTAGONISTAS DE 5HT2, INCLUYENDO LOS SUBTIPOS 5HT2A Y 5HT2C Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL Y OTROS RELACIONADOS CON RECEPTORES 5HT
PE2005001039A 2004-09-10 2005-09-08 Derivados de difenil eter como antagonistas de los receptores 5ht2 PE20060457A1 (es)

Applications Claiming Priority (2)

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US60899404P 2004-09-10 2004-09-10
US69917505P 2005-07-14 2005-07-14

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US (1) US20060058361A1 (es)
EP (1) EP1791807A1 (es)
JP (1) JP2008512438A (es)
AR (1) AR050798A1 (es)
BR (1) BRPI0514675A (es)
CA (1) CA2580024A1 (es)
GT (1) GT200500253A (es)
MX (1) MX2007002732A (es)
NL (1) NL1029919C2 (es)
PE (1) PE20060457A1 (es)
SV (1) SV2007002226A (es)
TW (1) TW200613255A (es)
UY (1) UY29108A1 (es)
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WO2007010350A1 (en) * 2005-07-19 2007-01-25 Pfizer Products Inc. Synthesis of therapeutic diphenyl ethers
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
SI3043784T1 (sl) 2013-09-09 2019-08-30 Peloton Therapeutics, Inc. Aril etri in njihova uporaba
WO2015095048A1 (en) 2013-12-16 2015-06-25 Peloton Therapeutics, Inc. Cyclic sulfone and sulfoximine analogs and uses thereof
EP3267792A4 (en) 2015-03-11 2018-09-26 Peloton Therapeutics, Inc. Compositions for use in treating pulmonary arterial hypertension
WO2016144826A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Substituted pyridines and uses thereof
US10512626B2 (en) 2015-03-11 2019-12-24 Peloton Therapeautics, Inc. Compositions for use in treating glioblastoma
WO2016144825A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Aromatic compounds and uses thereof
US10335388B2 (en) 2015-04-17 2019-07-02 Peloton Therapeutics, Inc. Combination therapy of a HIF-2-alpha inhibitor and an immunotherapeutic agent and uses thereof
US9796697B2 (en) 2015-06-12 2017-10-24 Peloton Therapeutics, Inc. Tricyclic inhibitors of HIF-2-alpha and uses thereof
CN105250316B (zh) * 2015-11-14 2018-01-19 西安力邦制药有限公司 一种含二联苯酚的抗癫痫药物组合
WO2018033448A1 (de) * 2016-08-16 2018-02-22 Bayer Cropscience Aktiengesellschaft Verfahren zur herstellung von 2-(3,6-dihalopyridin-2-yl)-3h-imidazol[4,5-c]pyridinderivaten und verwandten verbindungen durch umsetzung des 3h-imidazol[4,5-c]pyridinderivats mit einer metallorganischen zink-amin base
CN108794395B (zh) * 2018-07-06 2021-04-20 大连理工大学 一种2-喹啉酮类化合物的制备方法

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JP3916871B2 (ja) * 1999-02-23 2007-05-23 ファイザー・プロダクツ・インク Ｃｎｓ障害の治療のためのモノアミン再吸収阻害剤
EE200300084A (et) * 2000-08-31 2005-02-15 Pfizer Inc. Fenoksübensüülamiini derivaadid kui selektiivsed serotoniini tagasihaarde inhibiitorid
US20020123490A1 (en) * 2001-03-01 2002-09-05 Pfizer Inc. Combination treatment for anxiety, depression, obsessive compulsive disorder and psychosis
EP1260221A3 (en) * 2001-05-23 2002-12-18 Pfizer Products Inc. Combination treatment for depression and anxiety

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MX2007002732A (es) 2007-04-24
WO2006027684A1 (en) 2006-03-16
JP2008512438A (ja) 2008-04-24
SV2007002226A (es) 2007-03-20
AR050798A1 (es) 2006-11-22
BRPI0514675A (pt) 2008-06-17
CA2580024A1 (en) 2006-03-16
GT200500253A (es) 2006-04-17
UY29108A1 (es) 2006-04-28
NL1029919C2 (nl) 2006-10-12
TW200613255A (en) 2006-05-01
EP1791807A1 (en) 2007-06-06
US20060058361A1 (en) 2006-03-16
NL1029919A1 (nl) 2006-03-13

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