LV12539A - Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands - Google Patents
Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligandsInfo
- Publication number
- LV12539A LV12539A LV000029A LV000029A LV12539A LV 12539 A LV12539 A LV 12539A LV 000029 A LV000029 A LV 000029A LV 000029 A LV000029 A LV 000029A LV 12539 A LV12539 A LV 12539A
- Authority
- LV
- Latvia
- Prior art keywords
- substituted
- napthyridine
- carboxamides
- oxo
- agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention encompasses structures of Formula (I) or the pharmaceutically acceptable non-toxic salts thereof wherein: X is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and Y is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91818097A | 1997-08-25 | 1997-08-25 | |
PCT/US1998/017513 WO1999010347A1 (en) | 1997-08-25 | 1998-08-24 | Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
LV12539A true LV12539A (en) | 2000-10-20 |
LV12539B LV12539B (en) | 2001-01-20 |
Family
ID=25439933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-00-29A LV12539B (en) | 1997-08-25 | 2000-03-16 | Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1007526A1 (en) |
JP (1) | JP2001514181A (en) |
KR (1) | KR20010023313A (en) |
CN (1) | CN1268136A (en) |
AP (1) | AP2000001742A0 (en) |
AU (1) | AU753800B2 (en) |
BG (1) | BG104192A (en) |
BR (1) | BR9811362A (en) |
CA (1) | CA2301599C (en) |
EG (1) | EG21717A (en) |
HU (1) | HUP0003258A3 (en) |
IL (1) | IL134291A0 (en) |
IS (1) | IS5382A (en) |
LV (1) | LV12539B (en) |
NO (1) | NO20000822L (en) |
NZ (1) | NZ502548A (en) |
OA (1) | OA11293A (en) |
PE (1) | PE130999A1 (en) |
PL (1) | PL338783A1 (en) |
SI (1) | SI20270A (en) |
SK (1) | SK2162000A3 (en) |
TW (1) | TW574221B (en) |
WO (1) | WO1999010347A1 (en) |
YU (1) | YU10500A (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1177177B1 (en) * | 1999-05-06 | 2005-02-23 | Neurogen Corporation | Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands |
US6448246B1 (en) | 1999-05-25 | 2002-09-10 | Neurogen Corporation | Substituted 4H-1,4-benzothiazine-2-carboxamide: GABA brain receptor ligands |
US6562822B2 (en) | 2000-07-12 | 2003-05-13 | Pharmacia & Upjohn Company | Heterocyle carboxamides as antiviral agents |
US6730682B2 (en) | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
ATE430745T1 (en) | 2000-10-12 | 2009-05-15 | Merck & Co Inc | AZA- AND POLYAZA NAPHTHALENYL CARBOXAMIDES AS INHIBITORS OF HIV INTEGRASE |
AU1532802A (en) | 2000-10-12 | 2002-04-22 | Merck & Co Inc | Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors |
US6841558B2 (en) | 2000-10-12 | 2005-01-11 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors |
US20020151591A1 (en) * | 2000-10-17 | 2002-10-17 | Anabella Villalobos | Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders |
OA12554A (en) * | 2001-03-01 | 2006-06-07 | Pfizer Prod Inc | Use of GABA a inverse agonists in combination withnicotine receptor partial agonists, estrogen, sel ective estrogen modulators, or bitamin E for the treatment of cognitive disorders. |
AR036256A1 (en) | 2001-08-17 | 2004-08-25 | Merck & Co Inc | SODIUM SALT OF AN HIV INTEGRAS INHIBITOR, PROCESSES FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT |
AU2003216049B2 (en) | 2002-01-17 | 2008-07-17 | Merck Sharp & Dohme Corp. | Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors |
WO2003077857A2 (en) | 2002-03-15 | 2003-09-25 | Merck & Co., Inc. | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors |
WO2004106336A1 (en) * | 2003-05-27 | 2004-12-09 | Pfizer Products Inc. | Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides |
WO2004106334A2 (en) * | 2003-05-28 | 2004-12-09 | Pfizer Products Inc. | Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation |
PL2074123T3 (en) * | 2006-10-16 | 2013-04-30 | Bionomics Ltd | Novel anxiolytic compounds |
JP2010510314A (en) * | 2006-11-22 | 2010-04-02 | シーサイド セラピューティクス,エルエルシー | Method for treating mental retardation, Down syndrome, fragile X syndrome and autism |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR204813A1 (en) * | 1972-05-08 | 1976-03-05 | Yamanouchi Pharma Co Ltd | PROCESS FOR THE PREPARATION OF AMPYLICIN DERIVATIVES |
GB1433774A (en) * | 1973-02-26 | 1976-04-28 | Allen & Hanburys Ltd | Heterocyclic compounds apparatus for conveying articles |
US4374138A (en) * | 1981-11-13 | 1983-02-15 | Warner-Lambert Company | Antibacterial amide compounds, compositions, and methods of use |
DD295360A5 (en) * | 1987-07-03 | 1991-10-31 | Akad Wissenschaften | Process for the preparation of activated carboxylic acid esters |
DD279887A1 (en) * | 1987-07-03 | 1990-06-20 | Inst Pharmakologische Forschun | METHOD OF PREPARING D-ALPHA- (4 (1H) -1,5-NAPHTHYRIDONE-3-CARBOXAMIDO) -BENZYLPENICILLIN AND OTHER BETA LACTAMANTIBIOTICS |
DD279875A1 (en) * | 1987-07-03 | 1990-06-20 | Inst Pharmakologische Forschun | PROCESS FOR PREPARING ACTIVATED CARBONIC ACID ESTERS |
JPS6461461A (en) * | 1987-09-01 | 1989-03-08 | Otsuka Pharma Co Ltd | Benzohetero ring derivative |
-
1998
- 1998-08-24 HU HU0003258A patent/HUP0003258A3/en unknown
- 1998-08-24 SK SK216-2000A patent/SK2162000A3/en unknown
- 1998-08-24 CN CN98808578A patent/CN1268136A/en active Pending
- 1998-08-24 YU YU10500A patent/YU10500A/en unknown
- 1998-08-24 EP EP98943352A patent/EP1007526A1/en not_active Withdrawn
- 1998-08-24 WO PCT/US1998/017513 patent/WO1999010347A1/en not_active Application Discontinuation
- 1998-08-24 SI SI9820055A patent/SI20270A/en unknown
- 1998-08-24 AU AU91173/98A patent/AU753800B2/en not_active Ceased
- 1998-08-24 NZ NZ502548A patent/NZ502548A/en unknown
- 1998-08-24 IL IL13429198A patent/IL134291A0/en unknown
- 1998-08-24 KR KR1020007001948A patent/KR20010023313A/en not_active Application Discontinuation
- 1998-08-24 PL PL98338783A patent/PL338783A1/en unknown
- 1998-08-24 JP JP2000507675A patent/JP2001514181A/en active Pending
- 1998-08-24 CA CA002301599A patent/CA2301599C/en not_active Expired - Fee Related
- 1998-08-24 BR BR9811362-3A patent/BR9811362A/en not_active Application Discontinuation
- 1998-09-29 EG EG118098A patent/EG21717A/en active
- 1998-10-23 TW TW87117597A patent/TW574221B/en active
- 1998-11-13 PE PE1998001100A patent/PE130999A1/en not_active Application Discontinuation
-
2000
- 2000-02-01 AP APAP/P/2000/001742A patent/AP2000001742A0/en unknown
- 2000-02-18 OA OA1200000044A patent/OA11293A/en unknown
- 2000-02-18 NO NO20000822A patent/NO20000822L/en not_active Application Discontinuation
- 2000-02-22 IS IS5382A patent/IS5382A/en unknown
- 2000-02-25 BG BG104192A patent/BG104192A/en unknown
- 2000-03-16 LV LVP-00-29A patent/LV12539B/en unknown
Also Published As
Publication number | Publication date |
---|---|
BG104192A (en) | 2001-05-31 |
AU9117398A (en) | 1999-03-16 |
IL134291A0 (en) | 2001-04-30 |
BR9811362A (en) | 2000-08-22 |
SK2162000A3 (en) | 2001-03-12 |
KR20010023313A (en) | 2001-03-26 |
NO20000822D0 (en) | 2000-02-18 |
YU10500A (en) | 2002-10-18 |
CA2301599C (en) | 2003-03-25 |
OA11293A (en) | 2002-11-19 |
AP2000001742A0 (en) | 2000-02-24 |
HUP0003258A3 (en) | 2001-05-28 |
EG21717A (en) | 2002-02-27 |
NO20000822L (en) | 2000-04-13 |
HUP0003258A2 (en) | 2001-03-28 |
EP1007526A1 (en) | 2000-06-14 |
SI20270A (en) | 2000-12-31 |
CA2301599A1 (en) | 1999-03-04 |
WO1999010347A1 (en) | 1999-03-04 |
CN1268136A (en) | 2000-09-27 |
IS5382A (en) | 2000-02-22 |
JP2001514181A (en) | 2001-09-11 |
NZ502548A (en) | 2002-06-28 |
LV12539B (en) | 2001-01-20 |
TW574221B (en) | 2004-02-01 |
PE130999A1 (en) | 1999-12-16 |
PL338783A1 (en) | 2000-11-20 |
AU753800B2 (en) | 2002-10-31 |
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