NO20000822L - Substituted 4-oxo-3-carboxamides as GABA Brain Receptor Ligands - Google Patents

Substituted 4-oxo-3-carboxamides as GABA Brain Receptor Ligands

Info

Publication number
NO20000822L
NO20000822L NO20000822A NO20000822A NO20000822L NO 20000822 L NO20000822 L NO 20000822L NO 20000822 A NO20000822 A NO 20000822A NO 20000822 A NO20000822 A NO 20000822A NO 20000822 L NO20000822 L NO 20000822L
Authority
NO
Norway
Prior art keywords
substituted
agonists
carboxamides
oxo
receptor ligands
Prior art date
Application number
NO20000822A
Other languages
Norwegian (no)
Other versions
NO20000822D0 (en
Inventor
Pamela Albaugh
Robert W Desimone
Gang Liu
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of NO20000822D0 publication Critical patent/NO20000822D0/en
Publication of NO20000822L publication Critical patent/NO20000822L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Abstract

Foreliggende oppfinnelse omfatter strukturer med Formel (I) eller de farmasøytisk akseptable ikke-toksiske saltene derav, hvori: X er hydrogen, halogen, (u)substituert alkyl, (u)substituert alkoksy eller amino; og Y er (u)substituert alkyl, aryl eller heteroaryl, hvilke forbindelser er i høy grad selektive agonister, antagonister eller inverse agonister for GABAa hjernereseptorer eller pro-legemidler av agonister, antagonister eller inverse agonister for GABAa hjernereseptorer. Disse forbindelsene er nyttige for diagnose og behandling av angst, Down Syndrom, søvnforstyrrelse, kognitive forstyrrelser samt anfall og overdoser med benzodiazepin-legemidler og for forsterkning, av våkenhet.The present invention encompasses structures of Formula (I) or the pharmaceutically acceptable non-toxic salts thereof, wherein: X is hydrogen, halogen, (u) substituted alkyl, (u) substituted alkoxy or amino; and Y is (u) substituted alkyl, aryl or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or pro-drugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful for the diagnosis and treatment of anxiety, Down Syndrome, sleep disturbance, cognitive disorders as well as seizures and overdoses with benzodiazepine drugs and for the reinforcement, of wakefulness.

NO20000822A 1997-08-25 2000-02-18 Substituted 4-oxo-3-carboxamides as GABA Brain Receptor Ligands NO20000822L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91818097A 1997-08-25 1997-08-25
PCT/US1998/017513 WO1999010347A1 (en) 1997-08-25 1998-08-24 Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands

Publications (2)

Publication Number Publication Date
NO20000822D0 NO20000822D0 (en) 2000-02-18
NO20000822L true NO20000822L (en) 2000-04-13

Family

ID=25439933

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20000822A NO20000822L (en) 1997-08-25 2000-02-18 Substituted 4-oxo-3-carboxamides as GABA Brain Receptor Ligands

Country Status (24)

Country Link
EP (1) EP1007526A1 (en)
JP (1) JP2001514181A (en)
KR (1) KR20010023313A (en)
CN (1) CN1268136A (en)
AP (1) AP2000001742A0 (en)
AU (1) AU753800B2 (en)
BG (1) BG104192A (en)
BR (1) BR9811362A (en)
CA (1) CA2301599C (en)
EG (1) EG21717A (en)
HU (1) HUP0003258A3 (en)
IL (1) IL134291A0 (en)
IS (1) IS5382A (en)
LV (1) LV12539B (en)
NO (1) NO20000822L (en)
NZ (1) NZ502548A (en)
OA (1) OA11293A (en)
PE (1) PE130999A1 (en)
PL (1) PL338783A1 (en)
SI (1) SI20270A (en)
SK (1) SK2162000A3 (en)
TW (1) TW574221B (en)
WO (1) WO1999010347A1 (en)
YU (1) YU10500A (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2235883T3 (en) * 1999-05-06 2005-07-16 Neurogen Corporation 4-OXO-QUINOLINO-3-SUBSTITUTED CARBOXAMIDS: GABA CEREBRAL RECEIVERS LIGANDOS.
WO2000071528A1 (en) * 1999-05-25 2000-11-30 Neurogen Corporation 4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
EP1326610B1 (en) 2000-10-12 2006-11-15 Merck & Co., Inc. Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
CZ20031028A3 (en) 2000-10-12 2003-08-13 Merck & Co., Inc. Aza- and polyazanaphthalenyl carboxamides
AU1532802A (en) 2000-10-12 2002-04-22 Merck & Co Inc Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
US20020151591A1 (en) * 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
CZ20032338A3 (en) * 2001-03-01 2004-08-18 Pfizeráproductsáinc Use of GABA A inversion agonists in combination with partial nicotine receptor agonists, estrogen, estrogen selective modulators or vitamin E when treating cognitive disorders
AR036256A1 (en) 2001-08-17 2004-08-25 Merck & Co Inc SODIUM SALT OF AN HIV INTEGRAS INHIBITOR, PROCESSES FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
ES2291642T3 (en) 2002-01-17 2008-03-01 MERCK & CO., INC. USEFUL HYDROXINE FTIRIDINON CARBOXAMIDS AS INHIBITORS OF HIV INTEGRESS.
AU2003218130A1 (en) 2002-03-15 2003-09-29 Merck And Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
WO2004106336A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides
WO2004106334A2 (en) * 2003-05-28 2004-12-09 Pfizer Products Inc. Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation
DK2074123T3 (en) * 2006-10-16 2013-01-14 Bionomics Ltd NEW ANXIOLYTIC COMPOUNDS
EP2567696A1 (en) * 2006-11-22 2013-03-13 Seaside Therapeutics, Inc. Compositions for treating autism spectrum disorder

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204162A1 (en) * 1972-05-08 1975-11-28 Yamanouchi Pharma Co Ltd PROCESS FOR THE PREPARATION OF AMPICILLIN DERIVATIVES
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
DD279887A1 (en) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun METHOD OF PREPARING D-ALPHA- (4 (1H) -1,5-NAPHTHYRIDONE-3-CARBOXAMIDO) -BENZYLPENICILLIN AND OTHER BETA LACTAMANTIBIOTICS
DD279875A1 (en) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun PROCESS FOR PREPARING ACTIVATED CARBONIC ACID ESTERS
DD295360A5 (en) * 1987-07-03 1991-10-31 Akad Wissenschaften Process for the preparation of activated carboxylic acid esters
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative

Also Published As

Publication number Publication date
EG21717A (en) 2002-02-27
AU9117398A (en) 1999-03-16
IL134291A0 (en) 2001-04-30
SK2162000A3 (en) 2001-03-12
BG104192A (en) 2001-05-31
JP2001514181A (en) 2001-09-11
NO20000822D0 (en) 2000-02-18
OA11293A (en) 2002-11-19
AP2000001742A0 (en) 2000-02-24
PE130999A1 (en) 1999-12-16
SI20270A (en) 2000-12-31
HUP0003258A2 (en) 2001-03-28
LV12539A (en) 2000-10-20
LV12539B (en) 2001-01-20
CA2301599A1 (en) 1999-03-04
AU753800B2 (en) 2002-10-31
TW574221B (en) 2004-02-01
PL338783A1 (en) 2000-11-20
KR20010023313A (en) 2001-03-26
WO1999010347A1 (en) 1999-03-04
EP1007526A1 (en) 2000-06-14
HUP0003258A3 (en) 2001-05-28
IS5382A (en) 2000-02-22
NZ502548A (en) 2002-06-28
CN1268136A (en) 2000-09-27
CA2301599C (en) 2003-03-25
BR9811362A (en) 2000-08-22
YU10500A (en) 2002-10-18

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