YU10500A - Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands - Google Patents

Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands

Info

Publication number
YU10500A
YU10500A YU10500A YU10500A YU10500A YU 10500 A YU10500 A YU 10500A YU 10500 A YU10500 A YU 10500A YU 10500 A YU10500 A YU 10500A YU 10500 A YU10500 A YU 10500A
Authority
YU
Yugoslavia
Prior art keywords
substituted
napthyridine
carboxamides
oxo
agonists
Prior art date
Application number
YU10500A
Other languages
Serbo-Croatian (sh)
Inventor
Pamela Albaugh
Robert W. De Simone
Gang Liu
Original Assignee
Neurogen Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corporation filed Critical Neurogen Corporation
Publication of YU10500A publication Critical patent/YU10500A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Abstract

The present invention encompasses structures of Formula (I) or the pharmaceutically acceptable non-toxic salts thereof wherein: X is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and Y is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.
YU10500A 1997-08-25 1998-08-24 Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands YU10500A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91818097A 1997-08-25 1997-08-25

Publications (1)

Publication Number Publication Date
YU10500A true YU10500A (en) 2002-10-18

Family

ID=25439933

Family Applications (1)

Application Number Title Priority Date Filing Date
YU10500A YU10500A (en) 1997-08-25 1998-08-24 Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands

Country Status (24)

Country Link
EP (1) EP1007526A1 (en)
JP (1) JP2001514181A (en)
KR (1) KR20010023313A (en)
CN (1) CN1268136A (en)
AP (1) AP2000001742A0 (en)
AU (1) AU753800B2 (en)
BG (1) BG104192A (en)
BR (1) BR9811362A (en)
CA (1) CA2301599C (en)
EG (1) EG21717A (en)
HU (1) HUP0003258A3 (en)
IL (1) IL134291A0 (en)
IS (1) IS5382A (en)
LV (1) LV12539B (en)
NO (1) NO20000822L (en)
NZ (1) NZ502548A (en)
OA (1) OA11293A (en)
PE (1) PE130999A1 (en)
PL (1) PL338783A1 (en)
SI (1) SI20270A (en)
SK (1) SK2162000A3 (en)
TW (1) TW574221B (en)
WO (1) WO1999010347A1 (en)
YU (1) YU10500A (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002544197A (en) * 1999-05-06 2002-12-24 ニューロゲン コーポレイション Substituted 4-oxo-quinoline-3-carboxamides: GABA brain receptor ligand
US6448246B1 (en) 1999-05-25 2002-09-10 Neurogen Corporation Substituted 4H-1,4-benzothiazine-2-carboxamide: GABA brain receptor ligands
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
KR20030036922A (en) 2000-10-12 2003-05-09 머크 앤드 캄파니 인코포레이티드 Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
US6919351B2 (en) 2000-10-12 2005-07-19 Merck & Co., Inc. Aza-and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors
DE60124577T2 (en) 2000-10-12 2007-09-27 Merck & Co., Inc. AZA AND POLYAZA NAPHTHALENYL ACID ACID AMIDE AS HIV INTEGRASE INHIBITORS
US20020151591A1 (en) * 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
KR20030076717A (en) * 2001-03-01 2003-09-26 화이자 프로덕츠 인크. Use of GABAA Inverse Agonists in Combination with Nicotine Receptor Partial Agonists, Estrogen, Selective Estrogen Modulators, or Vitamin E for the Treatment of Cognitive Disorders
AR036256A1 (en) 2001-08-17 2004-08-25 Merck & Co Inc SODIUM SALT OF AN HIV INTEGRAS INHIBITOR, PROCESSES FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
US7279487B2 (en) 2002-01-17 2007-10-09 Merck & Co., Inc. Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
US7323460B2 (en) 2002-03-15 2008-01-29 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors
WO2004106336A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides
WO2004106334A2 (en) * 2003-05-28 2004-12-09 Pfizer Products Inc. Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation
AU2007312936B2 (en) * 2006-10-16 2013-09-26 Bionomics Limited Novel anxiolytic compounds
JP2010510314A (en) * 2006-11-22 2010-04-02 シーサイド セラピューティクス，エルエルシー Method for treating mental retardation, Down syndrome, fragile X syndrome and autism

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204813A1 (en) * 1972-05-08 1976-03-05 Yamanouchi Pharma Co Ltd PROCESS FOR THE PREPARATION OF AMPYLICIN DERIVATIVES
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
DD279875A1 (en) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun PROCESS FOR PREPARING ACTIVATED CARBONIC ACID ESTERS
DD279887A1 (en) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun METHOD OF PREPARING D-ALPHA- (4 (1H) -1,5-NAPHTHYRIDONE-3-CARBOXAMIDO) -BENZYLPENICILLIN AND OTHER BETA LACTAMANTIBIOTICS
DD295360A5 (en) * 1987-07-03 1991-10-31 Akad Wissenschaften Process for the preparation of activated carboxylic acid esters
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative

Also Published As

Publication number Publication date
PL338783A1 (en) 2000-11-20
AP2000001742A0 (en) 2000-02-24
NO20000822D0 (en) 2000-02-18
EP1007526A1 (en) 2000-06-14
CA2301599A1 (en) 1999-03-04
CN1268136A (en) 2000-09-27
AU9117398A (en) 1999-03-16
OA11293A (en) 2002-11-19
SI20270A (en) 2000-12-31
HUP0003258A2 (en) 2001-03-28
IS5382A (en) 2000-02-22
JP2001514181A (en) 2001-09-11
CA2301599C (en) 2003-03-25
LV12539B (en) 2001-01-20
BG104192A (en) 2001-05-31
NO20000822L (en) 2000-04-13
HUP0003258A3 (en) 2001-05-28
KR20010023313A (en) 2001-03-26
TW574221B (en) 2004-02-01
WO1999010347A1 (en) 1999-03-04
AU753800B2 (en) 2002-10-31
LV12539A (en) 2000-10-20
NZ502548A (en) 2002-06-28
EG21717A (en) 2002-02-27
PE130999A1 (en) 1999-12-16
IL134291A0 (en) 2001-04-30
SK2162000A3 (en) 2001-03-12
BR9811362A (en) 2000-08-22

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