IS5382A - Substituted 4-oxo-napthyridine-3-carboxamide associated with GABA receptors in the brain - Google Patents

Substituted 4-oxo-napthyridine-3-carboxamide associated with GABA receptors in the brain

Info

Publication number
IS5382A
IS5382A IS5382A IS5382A IS5382A IS 5382 A IS5382 A IS 5382A IS 5382 A IS5382 A IS 5382A IS 5382 A IS5382 A IS 5382A IS 5382 A IS5382 A IS 5382A
Authority
IS
Iceland
Prior art keywords
napthyridine
carboxamide
oxo
brain
substituted
Prior art date
Application number
IS5382A
Other languages
Icelandic (is)
Inventor
Albaugh Pamela
W. Desimone Robert
Liu Gang
Original Assignee
Neurogen Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corporation filed Critical Neurogen Corporation
Publication of IS5382A publication Critical patent/IS5382A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IS5382A 1997-08-25 2000-02-22 Substituted 4-oxo-napthyridine-3-carboxamide associated with GABA receptors in the brain IS5382A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91818097A 1997-08-25 1997-08-25
PCT/US1998/017513 WO1999010347A1 (en) 1997-08-25 1998-08-24 Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands

Publications (1)

Publication Number Publication Date
IS5382A true IS5382A (en) 2000-02-22

Family

ID=25439933

Family Applications (1)

Application Number Title Priority Date Filing Date
IS5382A IS5382A (en) 1997-08-25 2000-02-22 Substituted 4-oxo-napthyridine-3-carboxamide associated with GABA receptors in the brain

Country Status (24)

Country Link
EP (1) EP1007526A1 (en)
JP (1) JP2001514181A (en)
KR (1) KR20010023313A (en)
CN (1) CN1268136A (en)
AP (1) AP2000001742A0 (en)
AU (1) AU753800B2 (en)
BG (1) BG104192A (en)
BR (1) BR9811362A (en)
CA (1) CA2301599C (en)
EG (1) EG21717A (en)
HU (1) HUP0003258A3 (en)
IL (1) IL134291A0 (en)
IS (1) IS5382A (en)
LV (1) LV12539B (en)
NO (1) NO20000822L (en)
NZ (1) NZ502548A (en)
OA (1) OA11293A (en)
PE (1) PE130999A1 (en)
PL (1) PL338783A1 (en)
SI (1) SI20270A (en)
SK (1) SK2162000A3 (en)
TW (1) TW574221B (en)
WO (1) WO1999010347A1 (en)
YU (1) YU10500A (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE289593T1 (en) * 1999-05-06 2005-03-15 Neurogen Corp SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDE AS GABA BRAIN RECEPTOR LIGANDS
WO2000071528A1 (en) * 1999-05-25 2000-11-30 Neurogen Corporation 4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
EA200300449A1 (en) 2000-10-12 2003-10-30 Мерк Энд Ко., Инк. AZA- AND POLYAZA-NAPHTHALINILKARBOXAMIDES USEFUL AS HIV-INTEGRASES INHIBITORS
US6841558B2 (en) 2000-10-12 2005-01-11 Merck & Co., Inc. Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors
WO2002030426A1 (en) 2000-10-12 2002-04-18 Merck & Co., Inc. Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
US20020151591A1 (en) * 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
CN1494422A (en) * 2001-03-01 2004-05-05 �Ʒ� Use of GABAA inverse agonists in combination with nicotine receptor partial agonists, estrogen, selective estrogen modulators, or vitamin E for treatment of cognitive disorders
AR036256A1 (en) 2001-08-17 2004-08-25 Merck & Co Inc SODIUM SALT OF AN HIV INTEGRAS INHIBITOR, PROCESSES FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
US7279487B2 (en) 2002-01-17 2007-10-09 Merck & Co., Inc. Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
EP1496836B1 (en) 2002-03-15 2008-09-24 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
WO2004106336A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides
WO2004106334A2 (en) * 2003-05-28 2004-12-09 Pfizer Products Inc. Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation
DK2074123T3 (en) * 2006-10-16 2013-01-14 Bionomics Ltd NEW ANXIOLYTIC COMPOUNDS
WO2008066750A1 (en) * 2006-11-22 2008-06-05 Seaside Therapeutics, Llc Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204162A1 (en) * 1972-05-08 1975-11-28 Yamanouchi Pharma Co Ltd PROCESS FOR THE PREPARATION OF AMPICILLIN DERIVATIVES
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
DD279887A1 (en) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun METHOD OF PREPARING D-ALPHA- (4 (1H) -1,5-NAPHTHYRIDONE-3-CARBOXAMIDO) -BENZYLPENICILLIN AND OTHER BETA LACTAMANTIBIOTICS
DD295360A5 (en) * 1987-07-03 1991-10-31 Akad Wissenschaften Process for the preparation of activated carboxylic acid esters
DD279875A1 (en) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun PROCESS FOR PREPARING ACTIVATED CARBONIC ACID ESTERS
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative

Also Published As

Publication number Publication date
NO20000822L (en) 2000-04-13
YU10500A (en) 2002-10-18
AP2000001742A0 (en) 2000-02-24
BG104192A (en) 2001-05-31
EP1007526A1 (en) 2000-06-14
SK2162000A3 (en) 2001-03-12
PL338783A1 (en) 2000-11-20
LV12539A (en) 2000-10-20
CA2301599A1 (en) 1999-03-04
AU9117398A (en) 1999-03-16
WO1999010347A1 (en) 1999-03-04
JP2001514181A (en) 2001-09-11
OA11293A (en) 2002-11-19
EG21717A (en) 2002-02-27
SI20270A (en) 2000-12-31
TW574221B (en) 2004-02-01
NZ502548A (en) 2002-06-28
BR9811362A (en) 2000-08-22
IL134291A0 (en) 2001-04-30
AU753800B2 (en) 2002-10-31
HUP0003258A2 (en) 2001-03-28
NO20000822D0 (en) 2000-02-18
CN1268136A (en) 2000-09-27
LV12539B (en) 2001-01-20
KR20010023313A (en) 2001-03-26
CA2301599C (en) 2003-03-25
PE130999A1 (en) 1999-12-16
HUP0003258A3 (en) 2001-05-28

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