JPS6461461A - Benzohetero ring derivative - Google Patents

Benzohetero ring derivative

Info

Publication number
JPS6461461A
JPS6461461A JP62218274A JP21827487A JPS6461461A JP S6461461 A JPS6461461 A JP S6461461A JP 62218274 A JP62218274 A JP 62218274A JP 21827487 A JP21827487 A JP 21827487A JP S6461461 A JPS6461461 A JP S6461461A
Authority
JP
Japan
Prior art keywords
formula
lower alkyl
group
phenyl
group shown
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62218274A
Other languages
Japanese (ja)
Inventor
Shigeharu Tamada
Takafumi Fujioka
Hidenori Ogawa
Shuji Teramoto
Kazumi Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP62218274A priority Critical patent/JPS6461461A/en
Publication of JPS6461461A publication Critical patent/JPS6461461A/en
Pending legal-status Critical Current

Links

Landscapes

  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by formula I [R is H or group shown by formula II (R<3> is H, benzoyl which may contain lower alkoxy as a substituent group on the phenyl ring or phenyl lower alkyl); R<1> is H or phenyl lower alkyl; R<2> is H, lower alkoxycarbonyl or group shown by formula III (R<4> is phenyl lower alkyl which may contain 1-3 groups such as halogen or lower alkyl on the phenyl ring and hydroxyl group on the lower alkyl group); with the proviso that R<2> should be H when R is group shown by formula II; R<2> is group shown by formula III when R is H] and a salt thereof. EXAMPLE:6-(4-Benzyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline. USE:Showing increasing action on coronary blood flow amount and hypotensive action and useful as a drug having low toxicity. PREPARATION:For example, a compound shown by formula I is obtained as exhibited by the reaction formula (R<6> and R<7> are lower alkyl).
JP62218274A 1987-09-01 1987-09-01 Benzohetero ring derivative Pending JPS6461461A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62218274A JPS6461461A (en) 1987-09-01 1987-09-01 Benzohetero ring derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62218274A JPS6461461A (en) 1987-09-01 1987-09-01 Benzohetero ring derivative

Publications (1)

Publication Number Publication Date
JPS6461461A true JPS6461461A (en) 1989-03-08

Family

ID=16717296

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62218274A Pending JPS6461461A (en) 1987-09-01 1987-09-01 Benzohetero ring derivative

Country Status (1)

Country Link
JP (1) JPS6461461A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5129381A (en) * 1990-06-18 1992-07-14 Nissan Motor Co., Ltd. Fuel injection system for internal combustion engine
FR2672597A1 (en) * 1991-02-07 1992-08-14 Roussel Uclaf New N-substituted quinoline derivatives, process for their preparation, the new intermediates obtained, their application as medicaments and the pharmaceutical compositions containing them
FR2680511A1 (en) * 1991-08-20 1993-02-26 Roussel Uclaf N-Substituted quinoline derivatives, process for their preparation, intermediates obtained, their application as medicaments and the compositions containing them
FR2684671A1 (en) * 1991-11-20 1993-06-11 Roussel Uclaf New quinoline derivatives, process for their preparation and intermediates and their application as medicaments
US5773449A (en) * 1994-10-07 1998-06-30 Zenyaku Kogyo Kabushiki Kaisha Thioquinolone compounds which have useful pharmaceutical activity
WO1999010347A1 (en) * 1997-08-25 1999-03-04 Neurogen Corporation Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands
WO2000068202A1 (en) * 1999-05-06 2000-11-16 Neurogen Corporation Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands
WO2013129622A1 (en) 2012-03-02 2013-09-06 武田薬品工業株式会社 Heterocyclic compound and use therefor
US9777005B2 (en) 2012-11-19 2017-10-03 Takeda Pharmaceutical Company Limited Bicyclic heterocyclic compound containing a substituted pyrrole ring

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6163657A (en) * 1984-08-15 1986-04-01 ザ　ブーツ　カンパニー　ピーエルシー Quinolone derivative, manufacture and medicinal composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6163657A (en) * 1984-08-15 1986-04-01 ザ　ブーツ　カンパニー　ピーエルシー Quinolone derivative, manufacture and medicinal composition

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5129381A (en) * 1990-06-18 1992-07-14 Nissan Motor Co., Ltd. Fuel injection system for internal combustion engine
FR2672597A1 (en) * 1991-02-07 1992-08-14 Roussel Uclaf New N-substituted quinoline derivatives, process for their preparation, the new intermediates obtained, their application as medicaments and the pharmaceutical compositions containing them
FR2680511A1 (en) * 1991-08-20 1993-02-26 Roussel Uclaf N-Substituted quinoline derivatives, process for their preparation, intermediates obtained, their application as medicaments and the compositions containing them
FR2684671A1 (en) * 1991-11-20 1993-06-11 Roussel Uclaf New quinoline derivatives, process for their preparation and intermediates and their application as medicaments
US5773449A (en) * 1994-10-07 1998-06-30 Zenyaku Kogyo Kabushiki Kaisha Thioquinolone compounds which have useful pharmaceutical activity
WO1999010347A1 (en) * 1997-08-25 1999-03-04 Neurogen Corporation Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands
WO2000068202A1 (en) * 1999-05-06 2000-11-16 Neurogen Corporation Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands
US6413956B1 (en) * 1999-05-06 2002-07-02 Neurogen Corporation Substituted 4-oxo-quinoline-3-carboxamides
WO2013129622A1 (en) 2012-03-02 2013-09-06 武田薬品工業株式会社 Heterocyclic compound and use therefor
US9403802B2 (en) 2012-03-02 2016-08-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use therefor
US9777005B2 (en) 2012-11-19 2017-10-03 Takeda Pharmaceutical Company Limited Bicyclic heterocyclic compound containing a substituted pyrrole ring

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