BG104192A - Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands - Google Patents
Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligandsInfo
- Publication number
- BG104192A BG104192A BG104192A BG10419200A BG104192A BG 104192 A BG104192 A BG 104192A BG 104192 A BG104192 A BG 104192A BG 10419200 A BG10419200 A BG 10419200A BG 104192 A BG104192 A BG 104192A
- Authority
- BG
- Bulgaria
- Prior art keywords
- substituted
- carboxamides
- naphthyridine
- oxo
- agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention encompasses structures or the pharmaceutically acceptable non-toxic salts thereof of formula wherein: X is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and Y is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness. 105 claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91818097A | 1997-08-25 | 1997-08-25 | |
PCT/US1998/017513 WO1999010347A1 (en) | 1997-08-25 | 1998-08-24 | Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
BG104192A true BG104192A (en) | 2001-05-31 |
Family
ID=25439933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG104192A BG104192A (en) | 1997-08-25 | 2000-02-25 | Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1007526A1 (en) |
JP (1) | JP2001514181A (en) |
KR (1) | KR20010023313A (en) |
CN (1) | CN1268136A (en) |
AP (1) | AP2000001742A0 (en) |
AU (1) | AU753800B2 (en) |
BG (1) | BG104192A (en) |
BR (1) | BR9811362A (en) |
CA (1) | CA2301599C (en) |
EG (1) | EG21717A (en) |
HU (1) | HUP0003258A3 (en) |
IL (1) | IL134291A0 (en) |
IS (1) | IS5382A (en) |
LV (1) | LV12539B (en) |
NO (1) | NO20000822L (en) |
NZ (1) | NZ502548A (en) |
OA (1) | OA11293A (en) |
PE (1) | PE130999A1 (en) |
PL (1) | PL338783A1 (en) |
SI (1) | SI20270A (en) |
SK (1) | SK2162000A3 (en) |
TW (1) | TW574221B (en) |
WO (1) | WO1999010347A1 (en) |
YU (1) | YU10500A (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE289593T1 (en) * | 1999-05-06 | 2005-03-15 | Neurogen Corp | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDE AS GABA BRAIN RECEPTOR LIGANDS |
US6448246B1 (en) | 1999-05-25 | 2002-09-10 | Neurogen Corporation | Substituted 4H-1,4-benzothiazine-2-carboxamide: GABA brain receptor ligands |
US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US6730682B2 (en) | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US6562822B2 (en) | 2000-07-12 | 2003-05-13 | Pharmacia & Upjohn Company | Heterocyle carboxamides as antiviral agents |
ES2274913T3 (en) | 2000-10-12 | 2007-06-01 | MERCK & CO., INC. | AZA AND POLIAZA-NAFTALENIL CARBOXAMIDS USEFUL AS INTEGRATED HIV INHIBITORS. |
WO2002030426A1 (en) | 2000-10-12 | 2002-04-18 | Merck & Co., Inc. | Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors |
CZ20031028A3 (en) | 2000-10-12 | 2003-08-13 | Merck & Co., Inc. | Aza- and polyazanaphthalenyl carboxamides |
US20020151591A1 (en) * | 2000-10-17 | 2002-10-17 | Anabella Villalobos | Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders |
CN1494422A (en) * | 2001-03-01 | 2004-05-05 | �Ʒ� | Use of GABAA inverse agonists in combination with nicotine receptor partial agonists, estrogen, selective estrogen modulators, or vitamin E for treatment of cognitive disorders |
AR036256A1 (en) | 2001-08-17 | 2004-08-25 | Merck & Co Inc | SODIUM SALT OF AN HIV INTEGRAS INHIBITOR, PROCESSES FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT |
JP4523281B2 (en) | 2002-01-17 | 2010-08-11 | メルク・シャープ・エンド・ドーム・コーポレイション | Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors |
AU2003218130A1 (en) | 2002-03-15 | 2003-09-29 | Merck And Co., Inc. | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors |
WO2004106336A1 (en) * | 2003-05-27 | 2004-12-09 | Pfizer Products Inc. | Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides |
WO2004106334A2 (en) * | 2003-05-28 | 2004-12-09 | Pfizer Products Inc. | Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation |
PT2074123E (en) * | 2006-10-16 | 2013-01-22 | Bionomics Ltd | Novel anxiolytic compounds |
JP2010510314A (en) * | 2006-11-22 | 2010-04-02 | シーサイド セラピューティクス,エルエルシー | Method for treating mental retardation, Down syndrome, fragile X syndrome and autism |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR204162A1 (en) * | 1972-05-08 | 1975-11-28 | Yamanouchi Pharma Co Ltd | PROCESS FOR THE PREPARATION OF AMPICILLIN DERIVATIVES |
GB1433774A (en) * | 1973-02-26 | 1976-04-28 | Allen & Hanburys Ltd | Heterocyclic compounds apparatus for conveying articles |
US4374138A (en) * | 1981-11-13 | 1983-02-15 | Warner-Lambert Company | Antibacterial amide compounds, compositions, and methods of use |
DD279887A1 (en) * | 1987-07-03 | 1990-06-20 | Inst Pharmakologische Forschun | METHOD OF PREPARING D-ALPHA- (4 (1H) -1,5-NAPHTHYRIDONE-3-CARBOXAMIDO) -BENZYLPENICILLIN AND OTHER BETA LACTAMANTIBIOTICS |
DD279875A1 (en) * | 1987-07-03 | 1990-06-20 | Inst Pharmakologische Forschun | PROCESS FOR PREPARING ACTIVATED CARBONIC ACID ESTERS |
DD295360A5 (en) * | 1987-07-03 | 1991-10-31 | Akad Wissenschaften | Process for the preparation of activated carboxylic acid esters |
JPS6461461A (en) * | 1987-09-01 | 1989-03-08 | Otsuka Pharma Co Ltd | Benzohetero ring derivative |
-
1998
- 1998-08-24 PL PL98338783A patent/PL338783A1/en unknown
- 1998-08-24 HU HU0003258A patent/HUP0003258A3/en unknown
- 1998-08-24 JP JP2000507675A patent/JP2001514181A/en active Pending
- 1998-08-24 CA CA002301599A patent/CA2301599C/en not_active Expired - Fee Related
- 1998-08-24 CN CN98808578A patent/CN1268136A/en active Pending
- 1998-08-24 SI SI9820055A patent/SI20270A/en unknown
- 1998-08-24 WO PCT/US1998/017513 patent/WO1999010347A1/en not_active Application Discontinuation
- 1998-08-24 YU YU10500A patent/YU10500A/en unknown
- 1998-08-24 NZ NZ502548A patent/NZ502548A/en unknown
- 1998-08-24 SK SK216-2000A patent/SK2162000A3/en unknown
- 1998-08-24 AU AU91173/98A patent/AU753800B2/en not_active Ceased
- 1998-08-24 EP EP98943352A patent/EP1007526A1/en not_active Withdrawn
- 1998-08-24 IL IL13429198A patent/IL134291A0/en unknown
- 1998-08-24 BR BR9811362-3A patent/BR9811362A/en not_active Application Discontinuation
- 1998-08-24 KR KR1020007001948A patent/KR20010023313A/en not_active Application Discontinuation
- 1998-09-29 EG EG118098A patent/EG21717A/en active
- 1998-10-23 TW TW87117597A patent/TW574221B/en active
- 1998-11-13 PE PE1998001100A patent/PE130999A1/en not_active Application Discontinuation
-
2000
- 2000-02-01 AP APAP/P/2000/001742A patent/AP2000001742A0/en unknown
- 2000-02-18 OA OA1200000044A patent/OA11293A/en unknown
- 2000-02-18 NO NO20000822A patent/NO20000822L/en not_active Application Discontinuation
- 2000-02-22 IS IS5382A patent/IS5382A/en unknown
- 2000-02-25 BG BG104192A patent/BG104192A/en unknown
- 2000-03-16 LV LVP-00-29A patent/LV12539B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AP2000001742A0 (en) | 2000-02-24 |
CA2301599A1 (en) | 1999-03-04 |
SK2162000A3 (en) | 2001-03-12 |
IS5382A (en) | 2000-02-22 |
HUP0003258A2 (en) | 2001-03-28 |
EG21717A (en) | 2002-02-27 |
CA2301599C (en) | 2003-03-25 |
PE130999A1 (en) | 1999-12-16 |
IL134291A0 (en) | 2001-04-30 |
HUP0003258A3 (en) | 2001-05-28 |
AU753800B2 (en) | 2002-10-31 |
LV12539A (en) | 2000-10-20 |
SI20270A (en) | 2000-12-31 |
AU9117398A (en) | 1999-03-16 |
NO20000822L (en) | 2000-04-13 |
BR9811362A (en) | 2000-08-22 |
YU10500A (en) | 2002-10-18 |
KR20010023313A (en) | 2001-03-26 |
PL338783A1 (en) | 2000-11-20 |
WO1999010347A1 (en) | 1999-03-04 |
NO20000822D0 (en) | 2000-02-18 |
CN1268136A (en) | 2000-09-27 |
EP1007526A1 (en) | 2000-06-14 |
LV12539B (en) | 2001-01-20 |
OA11293A (en) | 2002-11-19 |
NZ502548A (en) | 2002-06-28 |
TW574221B (en) | 2004-02-01 |
JP2001514181A (en) | 2001-09-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BG104192A (en) | Substituted 4-oxo-naphthyridine-3-carboxamides as gaba brain receptor ligands | |
OA09579A (en) | Certain imidazoquinoxalines a new class of gaba brain receptor ligands | |
CA2175204A1 (en) | Certain Fused Pyrrolecarboxanilides; a New Class of GABA Brain Receptor Ligands | |
NZ330861A (en) | Fused pyrrolecarboxamides and use as a new class of GABA brain receptor ligands | |
AU4818000A (en) | Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands | |
NO20013001L (en) | 2,3,4,4A-tetrahydro-1H-pyrazino (1,2-A) quinoxaline-5 (6H) one derivatives which are 5HT2C agonists | |
DE60106641D1 (en) | CYCLOPENTA [B] [1,4] DIAZEPINO [6,7,1-HI] INDOLE AS 5HT2C ANTAGONISTS | |
TW200510324A (en) | 6-(2,2,2-trifluoroethylamino)-7-chiloro-2, 3, 4, 5-tetrahydro-1h-benzo[d]azepine as a 5-ht2c receptor agonist | |
WO2002000623A3 (en) | Aryl fused substituted 4-oxy-pyridines | |
WO1999043661A3 (en) | Substituted cycloalkyl-4-oxonicotinic carboxamides; gaba brain receptor ligands | |
AU2321597A (en) | Novel imidazo{1,5-c}quinazolines; a new class of gaba brain receptor ligands | |
DE60014339T8 (en) | ARYL AND HETEROARYL-CONDENSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAA RECEPTORS | |
AP2002002420A0 (en) | Fused pyrrolecarboxamides: gaba brain receptor ligands. | |
NZ533358A (en) | 3,4-Dihydro-1H-isoquinolin-2-yl-derivatives for use as NK2 receptor antagonists | |
CA2223936A1 (en) | Novel substituted aryl and cycloalkyl imidazolones; a new class of gaba brain receptor ligands | |
DE69926378D1 (en) | OXO-PYRIDOIMIDAZOLE-CARBOXAMIDE: GABA RECEPTOR LIGANDS IN THE BRAIN | |
CA2249562A1 (en) | Certain fused pyrrolecarboxamides as gaba brain receptor ligands | |
MY107732A (en) | Certain imidazoquinoxalines; a new class of gaba brain receptor ligands. | |
DE69907448D1 (en) | PYRIDO [2,3-B] INDOLICINE DERIVATIVES AND AZA ANALOGS: CRF1 SPECIFIC LIGANDS | |
MX9709771A (en) | Novel substituted aryl and cycloalkyl imidazolones; a new class of gaba brain receptor ligands. | |
AR007742A1 (en) | FUSIONED PYROLCARBOXANILIDES; A NEW KIND OF LIGAND GABA BRAIN RECEPTORS. | |
BG96204A (en) | IMIDAZOQUINOXALINES, A NEW CLASS OF GAVA BRAIN RECEPTOR LIGANDS |