YU10500A - Supstituisani 4-okso-naptiridin-3-karboksamidi kao gaba moždani receptorski liganidi - Google Patents

Supstituisani 4-okso-naptiridin-3-karboksamidi kao gaba moždani receptorski liganidi

Info

Publication number
YU10500A
YU10500A YU10500A YU10500A YU10500A YU 10500 A YU10500 A YU 10500A YU 10500 A YU10500 A YU 10500A YU 10500 A YU10500 A YU 10500A YU 10500 A YU10500 A YU 10500A
Authority
YU
Yugoslavia
Prior art keywords
substituted
napthyridine
carboxamides
oxo
agonists
Prior art date
Application number
YU10500A
Other languages
English (en)
Inventor
Pamela Albaugh
Robert W. De Simone
Gang Liu
Original Assignee
Neurogen Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corporation filed Critical Neurogen Corporation
Publication of YU10500A publication Critical patent/YU10500A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Abstract

Predmetni pronalazak obuhvata strukture formule: ili njihove farmaceutski prihvatljive ne-toksične soli gde: X je vodonik, halogen, (ne)supstituisan alkil, (ne)supstituisan alkoksi ili amino; i Y je (ne)supstituisan alkil, aril ili heteroaril. Ova jedinjenja su veoma selektivni agonisti, antagonisti ili inverzni agonisti za GABAa moždane receptore ili prolekove agonista, antagonista ili inverznih agonista za GABAa moždane receptore. Ova jedinjenja su primenljiva u dijagnoziranju i treetiranju anksietije, Down sindroma, poremećaja spavanja, spoznaje i udara i prekomernog doziranja sa benzodiazepinskim lekovima i za pojačavanje pažnje.[The present invention encompasses structures of Formula (I) or the pharmaceutically acceptable non-toxic salts thereof wherein: X is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and Y is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.
YU10500A 1997-08-25 1998-08-24 Supstituisani 4-okso-naptiridin-3-karboksamidi kao gaba moždani receptorski liganidi YU10500A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91818097A 1997-08-25 1997-08-25

Publications (1)

Publication Number Publication Date
YU10500A true YU10500A (sh) 2002-10-18

Family

ID=25439933

Family Applications (1)

Application Number Title Priority Date Filing Date
YU10500A YU10500A (sh) 1997-08-25 1998-08-24 Supstituisani 4-okso-naptiridin-3-karboksamidi kao gaba moždani receptorski liganidi

Country Status (24)

Country Link
EP (1) EP1007526A1 (sh)
JP (1) JP2001514181A (sh)
KR (1) KR20010023313A (sh)
CN (1) CN1268136A (sh)
AP (1) AP2000001742A0 (sh)
AU (1) AU753800B2 (sh)
BG (1) BG104192A (sh)
BR (1) BR9811362A (sh)
CA (1) CA2301599C (sh)
EG (1) EG21717A (sh)
HU (1) HUP0003258A3 (sh)
IL (1) IL134291A0 (sh)
IS (1) IS5382A (sh)
LV (1) LV12539B (sh)
NO (1) NO20000822L (sh)
NZ (1) NZ502548A (sh)
OA (1) OA11293A (sh)
PE (1) PE130999A1 (sh)
PL (1) PL338783A1 (sh)
SI (1) SI20270A (sh)
SK (1) SK2162000A3 (sh)
TW (1) TW574221B (sh)
WO (1) WO1999010347A1 (sh)
YU (1) YU10500A (sh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2371472A1 (en) * 1999-05-06 2000-11-16 Neurogen Corporation Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands
WO2000071528A1 (en) * 1999-05-25 2000-11-30 Neurogen Corporation 4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
SK4322003A3 (en) 2000-10-12 2003-09-11 Merck & Co Inc Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
DE60128936T2 (de) 2000-10-12 2008-04-10 Merck & Co, Inc. Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
JP2004517860A (ja) 2000-10-12 2004-06-17 メルク　エンド　カムパニー　インコーポレーテッド Ｈｉｖインテグラーゼ阻害薬として有用なアザ−およびポリアザ−ナフタレニルカルボキサミド類
US20020151591A1 (en) * 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
HUP0303448A3 (en) * 2001-03-01 2005-05-30 Pfizer Prod Inc Use of gabaa inverse agonists in combination with nicotine receptor partial agonists, estrogen, selective estrogen modulators, or vitamin e for the treatment of cognitive disorders
AR036256A1 (es) 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
AU2003216049B2 (en) 2002-01-17 2008-07-17 Merck Sharp & Dohme Corp. Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
ATE409187T1 (de) 2002-03-15 2008-10-15 Merck & Co Inc N-(substituierte benzyl)-8-hydroxy-1,6- naphthyridin-7- carbonsäureamide als hiv- integrase-hemmer
WO2004106336A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides
WO2004106334A2 (en) * 2003-05-28 2004-12-09 Pfizer Products Inc. Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation
WO2008046135A1 (en) * 2006-10-16 2008-04-24 Bionomics Limited Novel anxiolytic compounds
AU2007325836B2 (en) * 2006-11-22 2011-07-21 Clinical Research Associates, Llc Methods of treating mental retardation, Down's syndrome, fragile X syndrome and autism

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204162A1 (es) * 1972-05-08 1975-11-28 Yamanouchi Pharma Co Ltd Proceso para la preparacion de derivados de ampicilina
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
DD279887A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von d-alpha-(4(1h)-1,5-naphthyridon-3-carboxamido)-benzylpenicillin und anderen beta-lactamantibiotika
DD295360A5 (de) * 1987-07-03 1991-10-31 Akad Wissenschaften Verfahren zur Herstellung von aktivierten Carbonsäureestern
DD279875A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von aktivierten carbonsaeureestern
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative

Also Published As

Publication number Publication date
IL134291A0 (en) 2001-04-30
SI20270A (sl) 2000-12-31
AP2000001742A0 (en) 2000-02-24
BG104192A (en) 2001-05-31
EP1007526A1 (en) 2000-06-14
CA2301599C (en) 2003-03-25
TW574221B (en) 2004-02-01
CA2301599A1 (en) 1999-03-04
KR20010023313A (ko) 2001-03-26
NO20000822L (no) 2000-04-13
NO20000822D0 (no) 2000-02-18
WO1999010347A1 (en) 1999-03-04
AU9117398A (en) 1999-03-16
IS5382A (is) 2000-02-22
LV12539B (en) 2001-01-20
AU753800B2 (en) 2002-10-31
HUP0003258A2 (en) 2001-03-28
LV12539A (en) 2000-10-20
CN1268136A (zh) 2000-09-27
PE130999A1 (es) 1999-12-16
HUP0003258A3 (en) 2001-05-28
OA11293A (en) 2002-11-19
SK2162000A3 (en) 2001-03-12
BR9811362A (pt) 2000-08-22
JP2001514181A (ja) 2001-09-11
PL338783A1 (en) 2000-11-20
NZ502548A (en) 2002-06-28
EG21717A (en) 2002-02-27

Similar Documents

Publication Publication Date Title
YU10500A (sh) Supstituisani 4-okso-naptiridin-3-karboksamidi kao gaba moždani receptorski liganidi
AU4818000A (en) Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands
CA2175204A1 (en) Certain Fused Pyrrolecarboxanilides; a New Class of GABA Brain Receptor Ligands
NZ330861A (en) Fused pyrrolecarboxamides and use as a new class of GABA brain receptor ligands
DK0555391T3 (da) Visse imidazoquinoxaliner; en ny klasse GABA-receptorligander i hjernen
DE60106641D1 (de) Cyclopenta[b][1,4] diazepino[6,7,1-hi]indole als 5ht2c antagonisten
NO20013001L (no) 2,3,4,4A-tetrahydro-1H-pyrazino(1,2-A)kinoksalin-5(6H)on- derivater som er 5HT2C-agonister
TW200510324A (en) 6-(2,2,2-trifluoroethylamino)-7-chiloro-2, 3, 4, 5-tetrahydro-1h-benzo[d]azepine as a 5-ht2c receptor agonist
CA2091986A1 (en) Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands
PT1666462E (pt) Derivados de n-[1h-indol-5-il]-naftaleno-1-sulfonamida e compostos associados enquanto antagonistas do receptor 5- ht6 de serotonina para o tratamento de distúrbios do sistema nervoso central
WO2002000623A3 (en) Aryl fused substituted 4-oxy-pyridines
AU2794099A (en) Substituted cycloalkyl-4-oxonicotinic carboxamides; gaba brain receptor ligands
AU2321597A (en) Novel imidazo{1,5-c}quinazolines; a new class of gaba brain receptor ligands
DE60014339T8 (de) Aryl- und heteroaryl-kondensierte aminoalkyl-imidazol-derivate: selektive modulatoren der gabaa-rezeptoren
NZ533358A (en) 3,4-Dihydro-1H-isoquinolin-2-yl-derivatives for use as NK2 receptor antagonists
CA2223936A1 (en) Novel substituted aryl and cycloalkyl imidazolones; a new class of gaba brain receptor ligands
ATE300539T1 (de) Oxo-pyridoimidazol-carboxamide: gaba-rezeptor- liganden im gehirn
CA2249562A1 (en) Certain fused pyrrolecarboxamides as gaba brain receptor ligands
DE69907448D1 (de) Pyrido[2,3-b]indolizinderivate und aza analoge: crf1 spezifische liganden
TH42836A (th) ซับสทิทิวเทด 4-ออกโซ-แนฟธิริดีน-3-คาร์บอกแซมีด; gaba เบรน รีเซปเตอร์ ลิแกนด์
MY107732A (en) Certain imidazoquinoxalines; a new class of gaba brain receptor ligands.
MX9709771A (es) Nuevas aril y cicloalquil imidazolonas substituidas, una clase de ligandos receptores de acido gamma-aminobutirico del cerebro.
YU35292A (sh) Izvesni imidazohinoksalini nova klasa gaba moždanih receptorskih liganada