ATE277927T1 - Aryl- und heteroaryl-kondensierte aminoalkyl- imidazol-derivate: selektive modulatoren der gabaa-rezeptoren - Google Patents
Aryl- und heteroaryl-kondensierte aminoalkyl- imidazol-derivate: selektive modulatoren der gabaa-rezeptorenInfo
- Publication number
- ATE277927T1 ATE277927T1 AT00919975T AT00919975T ATE277927T1 AT E277927 T1 ATE277927 T1 AT E277927T1 AT 00919975 T AT00919975 T AT 00919975T AT 00919975 T AT00919975 T AT 00919975T AT E277927 T1 ATE277927 T1 AT E277927T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- aryl
- imidazole derivatives
- gabaa receptors
- selective modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12752699P | 1999-04-02 | 1999-04-02 | |
| US28535799A | 1999-04-02 | 1999-04-02 | |
| PCT/US2000/008610 WO2000059905A1 (en) | 1999-04-02 | 2000-03-31 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277927T1 true ATE277927T1 (de) | 2004-10-15 |
Family
ID=26825721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00919975T ATE277927T1 (de) | 1999-04-02 | 2000-03-31 | Aryl- und heteroaryl-kondensierte aminoalkyl- imidazol-derivate: selektive modulatoren der gabaa-rezeptoren |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7348326B2 (de) |
| EP (1) | EP1165557B1 (de) |
| JP (1) | JP2002541151A (de) |
| AT (1) | ATE277927T1 (de) |
| AU (1) | AU4058000A (de) |
| BR (1) | BR0009539A (de) |
| CA (1) | CA2369557A1 (de) |
| DE (1) | DE60014339T8 (de) |
| ES (1) | ES2226812T3 (de) |
| MX (1) | MXPA01009949A (de) |
| WO (1) | WO2000059905A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6281237B1 (en) | 1999-04-02 | 2001-08-28 | Neurogen Corporation | N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives |
| JP2002541145A (ja) * | 1999-04-02 | 2002-12-03 | ニューロゲン コーポレイション | アリールおよびヘテロアリール縮合アミノアルキル−イミダゾール誘導体：ブラジキニンｂ２受容体選択性モジュレータ |
| KR20030060904A (ko) * | 2000-10-06 | 2003-07-16 | 뉴로젠 코포레이션 | Ｃｒｆ 수용체 조절자로서 벤즈이미다졸 및 인돌 유도체 |
| PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| CA2472470A1 (en) | 2002-01-10 | 2003-07-24 | Neurogen Corporation | Melanin concentrating hormone receptor ligands: substituted benzoimidazole analogues |
| PE20040804A1 (es) * | 2002-12-19 | 2004-12-31 | Boehringer Ingelheim Pharma | DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa |
| EP1594848A1 (de) * | 2003-02-19 | 2005-11-16 | Neurogen Corporation | Arylsäurepyrimidinylmethylamide, -pyridazinylmethylamide undverwandte verbindungen |
| ES2222813B1 (es) * | 2003-07-24 | 2005-12-16 | Ferrer Internacional, S.A. | N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados. |
| DK1648899T3 (da) * | 2003-07-25 | 2007-04-02 | Neurogen Corp | Imidazopyrimidiner og triazolopyrimidiner: benzodiazepinreceptorligander |
| RU2006120549A (ru) * | 2003-11-14 | 2007-12-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Тиазолы и оксазолы, применяемые в качестве модуляторов транспортеров арт-связывающей кассеты |
| US7271271B2 (en) * | 2004-06-28 | 2007-09-18 | Amgen Sf, Llc | Imidazolo-related compounds, compositions and methods for their use |
| US8815881B2 (en) * | 2010-08-09 | 2014-08-26 | Hoffmann-La Roche Inc. | 1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds |
| WO2012047538A1 (en) | 2010-10-06 | 2012-04-12 | Glaxosmithkline Llc | Benzimidazole derivatives as pi3 kinase inhibitors |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| AR095883A1 (es) * | 2013-04-18 | 2015-11-18 | Astellas Pharma Inc | Compuestos de acetamida heterocíclica |
| JP2023512038A (ja) * | 2020-01-29 | 2023-03-23 | フォグホーン セラピューティクス インコーポレイテッド | 化合物及びその使用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527819A (en) * | 1991-09-06 | 1996-06-18 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
| AU675484B2 (en) * | 1993-03-24 | 1997-02-06 | Neurosearch A/S | Benzimidazole compounds, their use and preparation |
| JPH10504808A (ja) * | 1994-06-29 | 1998-05-12 | スミスクライン・ビーチャム・コーポレイション | ビトロネクチン受容体拮抗物質 |
| DE69617665T2 (de) * | 1995-04-21 | 2002-05-08 | Neurosearch As Ballerup | Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes |
| EP0869787A4 (de) * | 1995-12-29 | 1999-03-24 | Smithkline Beecham Corp | Vitronectinrezeptorantagonisten |
| US6218547B1 (en) * | 1996-10-21 | 2001-04-17 | Neurosearch A/S | 1-phenyl-benzimidazole compounds and their use as GABA-a receptor modulators |
| US6380210B1 (en) * | 1999-04-02 | 2002-04-30 | Neurogen Corporation | Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
-
2000
- 2000-03-31 WO PCT/US2000/008610 patent/WO2000059905A1/en active IP Right Grant
- 2000-03-31 ES ES00919975T patent/ES2226812T3/es not_active Expired - Lifetime
- 2000-03-31 JP JP2000609416A patent/JP2002541151A/ja not_active Withdrawn
- 2000-03-31 EP EP00919975A patent/EP1165557B1/de not_active Expired - Lifetime
- 2000-03-31 AT AT00919975T patent/ATE277927T1/de not_active IP Right Cessation
- 2000-03-31 MX MXPA01009949A patent/MXPA01009949A/es active IP Right Grant
- 2000-03-31 BR BRPI0009539-7A patent/BR0009539A/pt not_active Application Discontinuation
- 2000-03-31 AU AU40580/00A patent/AU4058000A/en not_active Abandoned
- 2000-03-31 CA CA002369557A patent/CA2369557A1/en not_active Abandoned
- 2000-03-31 DE DE60014339T patent/DE60014339T8/de not_active Expired - Fee Related
-
2005
- 2005-12-06 US US11/295,173 patent/US7348326B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1165557A1 (de) | 2002-01-02 |
| CA2369557A1 (en) | 2000-10-12 |
| MXPA01009949A (es) | 2003-07-14 |
| DE60014339T2 (de) | 2006-02-09 |
| EP1165557B1 (de) | 2004-09-29 |
| BR0009539A (pt) | 2006-06-06 |
| JP2002541151A (ja) | 2002-12-03 |
| US20060160842A1 (en) | 2006-07-20 |
| US7348326B2 (en) | 2008-03-25 |
| AU4058000A (en) | 2000-10-23 |
| ES2226812T3 (es) | 2005-04-01 |
| DE60014339D1 (de) | 2004-11-04 |
| DE60014339T8 (de) | 2006-04-27 |
| WO2000059905A1 (en) | 2000-10-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE277927T1 (de) | Aryl- und heteroaryl-kondensierte aminoalkyl- imidazol-derivate: selektive modulatoren der gabaa-rezeptoren | |
| ATE289593T1 (de) | Substituierte 4-oxo-chinolin-3-carboxamide als gaba gehirnrezeptorliganden | |
| DK0555391T3 (da) | Visse imidazoquinoxaliner; en ny klasse GABA-receptorligander i hjernen | |
| DE60114227D1 (de) | 2,4-substituierte pyridinderivate | |
| CA2175204A1 (en) | Certain Fused Pyrrolecarboxanilides; a New Class of GABA Brain Receptor Ligands | |
| PT1147110E (pt) | Derivados de pirazino (aza)-indol | |
| CY1106645T1 (el) | Παραγωγα 1,2,4 τριαμινοβενζολης χρησιμα για τη θεραπευτικη αντιμετωπιση διαταραχων του κεντρικου νευρικου συστηματος | |
| WO2002000623A3 (en) | Aryl fused substituted 4-oxy-pyridines | |
| ES2065691T3 (es) | Derivados de quinuclidina. | |
| UA49001C2 (uk) | Піролкарбоксаміди як ліганди рецепторів гамк головного мозку | |
| ATE435010T1 (de) | Verwendung von retinoid rezeptor antagonisten für die behandlung von knochen und knorpel pathologien | |
| BR9908321A (pt) | Composto | |
| CA2301599A1 (en) | Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands | |
| ATE236134T1 (de) | Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren | |
| CA2223936A1 (en) | Novel substituted aryl and cycloalkyl imidazolones; a new class of gaba brain receptor ligands | |
| DE69925160D1 (de) | Arylpiperidin- und aryl-1,2,5,6-tetrahydropyridinamid-derivate mit 5ht1a rezeptor aktivität | |
| EP1172106A3 (de) | Werwendung von fluoralkoxybenzylaminoderivate stickstoffhaltiger heterocyclen als substanz p antagonisten | |
| DE69926378D1 (de) | Oxo-pyridoimidazol-carboxamide: gaba-rezeptor-liganden im gehirn | |
| MY107732A (en) | Certain imidazoquinoxalines; a new class of gaba brain receptor ligands. | |
| CA2249562A1 (en) | Certain fused pyrrolecarboxamides as gaba brain receptor ligands | |
| MX9709771A (es) | Nuevas aril y cicloalquil imidazolonas substituidas, una clase de ligandos receptores de acido gamma-aminobutirico del cerebro. | |
| NO20053612D0 (no) | 1,2,4-triaminobenzenderivater nyttige for behandling av forstyrrelser i sentralnervesystemet | |
| YU35292A (sh) | Izvesni imidazohinoksalini nova klasa gaba moždanih receptorskih liganada |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |