ATE291021T1 - Oxytocin agonisten - Google Patents

Oxytocin agonisten

Info

Publication number
ATE291021T1
ATE291021T1 AT02732974T AT02732974T ATE291021T1 AT E291021 T1 ATE291021 T1 AT E291021T1 AT 02732974 T AT02732974 T AT 02732974T AT 02732974 T AT02732974 T AT 02732974T AT E291021 T1 ATE291021 T1 AT E291021T1
Authority
AT
Austria
Prior art keywords
oxytocin agonists
general formula
compounds
agonists
group
Prior art date
Application number
AT02732974T
Other languages
English (en)
Inventor
Gary Robert William Pitt
Michael Bryan Ferring Roe
David Philip Ferring Rooker
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Application granted granted Critical
Publication of ATE291021T1 publication Critical patent/ATE291021T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Current-Collector Devices For Electrically Propelled Vehicles (AREA)
  • Tea And Coffee (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT02732974T 2001-06-25 2002-06-24 Oxytocin agonisten ATE291021T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0115515.9A GB0115515D0 (en) 2001-06-25 2001-06-25 Oxytocin agonisys
PCT/GB2002/002872 WO2003000692A2 (en) 2001-06-25 2002-06-24 Oxytocin agonists

Publications (1)

Publication Number Publication Date
ATE291021T1 true ATE291021T1 (de) 2005-04-15

Family

ID=9917320

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02732974T ATE291021T1 (de) 2001-06-25 2002-06-24 Oxytocin agonisten

Country Status (23)

Country Link
US (1) US20040235753A1 (de)
EP (1) EP1399436B1 (de)
JP (1) JP2005500317A (de)
KR (1) KR20040010762A (de)
CN (1) CN1606553A (de)
AT (1) ATE291021T1 (de)
CA (1) CA2450480A1 (de)
CZ (1) CZ20033414A3 (de)
DE (1) DE60203290T2 (de)
DK (1) DK1399436T3 (de)
ES (1) ES2239717T3 (de)
GB (1) GB0115515D0 (de)
HK (1) HK1064666A1 (de)
HU (1) HUP0400368A3 (de)
IL (1) IL159289A0 (de)
MX (1) MXPA03011980A (de)
NO (1) NO20035772L (de)
NZ (1) NZ530035A (de)
PL (1) PL367538A1 (de)
PT (1) PT1399436E (de)
RU (1) RU2309156C2 (de)
WO (1) WO2003000692A2 (de)
ZA (1) ZA200309626B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4179782B2 (ja) 2000-04-26 2008-11-12 富士通株式会社 無線受信装置及び無線通信システム
ES2277640T3 (es) 2002-02-27 2007-07-16 Ferring Bv Productos intermedios y metodos para preparar analogos de heptapeptido de oxitocina.
EP1449844A1 (de) * 2003-02-14 2004-08-25 Ferring B.V. benzamidderivate als oxytocin-agonisten und vasopressin-antagonisten
EP1512687A1 (de) * 2003-09-05 2005-03-09 Ferring B.V. Piperazine als Oxytocin-Agonisten
EP1632494A1 (de) * 2004-08-24 2006-03-08 Ferring B.V. Vasopressin v1a antagonisten
KR20080063848A (ko) * 2005-10-24 2008-07-07 와이어쓰 옥시토신 수용체 작용제로 유용한 트리사이클릭 화합물
EP2146722A4 (de) * 2007-05-10 2011-08-03 Amr Technology Inc Aryl- und heteroarylsubstituierte tetrahydrobenzo-1,4-diazepine und ihre verwendung zur blockierung der wiederaufnahme von norepinephrin, dopamin und serotonin
WO2009000878A1 (en) * 2007-06-28 2008-12-31 Novartis Ag Kallikrein 7 modulators
KR20100059859A (ko) * 2007-09-11 2010-06-04 몬도바이오테크 래보래토리즈 아게 치료제로서의 c형 나트륨이뇨 펩티드 단독 또는 뉴로펩티드 af와의 배합물의 용도
JP2010539018A (ja) * 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 治療剤としてのペプチドの使用
KR20100075439A (ko) * 2007-09-11 2010-07-02 몬도바이오테크 래보래토리즈 아게 치료제로서의 감마 1 msh 단독 또는 펜타가스트린과의 배합물
US20100204150A1 (en) * 2007-09-11 2010-08-12 Dorian Bevec Use of a peptide as a therapeutic agent
WO2009033820A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
AR068509A1 (es) * 2007-09-19 2009-11-18 Jerini Ag Antagosnistas del receptor de bradiquinina b1
WO2011147889A1 (en) 2010-05-25 2011-12-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the treatment of a feeding disorder with early-onset in a patient
GB201105537D0 (en) * 2011-03-31 2011-05-18 Vantia Ltd New process
CN103159641A (zh) * 2011-12-14 2013-06-19 天津泰普药品科技发展有限公司 托伐普坦中间体2-甲酸-5-(2-甲基苯甲酰氨基)甲苯的制备方法
EP3226688B1 (de) * 2014-12-05 2020-07-01 Merck Sharp & Dohme Corp. Tricyclische verbindungen als inhibitoren von mutanten idh-enzymen
CN107922420B (zh) 2015-07-06 2021-12-31 金奥克斯治疗有限公司 用于治疗社交障碍和药物使用障碍的治疗性化合物和组合物
CN110248944A (zh) * 2016-12-12 2019-09-17 悉尼大学 非肽催产素受体激动剂
KR20170035351A (ko) 2017-01-06 2017-03-30 셰플러코리아(유) 볼베어링용 케이지
WO2021042178A1 (en) * 2019-09-06 2021-03-11 Kinoxis Therapeutics Pty Ltd Treatment of opioid withdrawal

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665441B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
CA2358894A1 (en) * 1999-02-04 2000-08-10 American Home Products Corporation Tricyclic pyridine n-oxides vasopressin agonists
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0015601D0 (en) * 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents

Also Published As

Publication number Publication date
EP1399436A2 (de) 2004-03-24
IL159289A0 (en) 2004-06-01
GB0115515D0 (en) 2001-08-15
CZ20033414A3 (en) 2004-05-12
HUP0400368A3 (en) 2007-05-29
WO2003000692A2 (en) 2003-01-03
RU2003136152A (ru) 2005-05-20
EP1399436B1 (de) 2005-03-16
MXPA03011980A (es) 2004-03-26
WO2003000692A3 (en) 2003-05-15
PT1399436E (pt) 2005-07-29
DK1399436T3 (da) 2005-05-30
DE60203290T2 (de) 2006-02-02
CN1606553A (zh) 2005-04-13
ZA200309626B (en) 2004-05-12
NO20035772L (no) 2003-12-22
JP2005500317A (ja) 2005-01-06
PL367538A1 (en) 2005-02-21
NZ530035A (en) 2004-06-25
US20040235753A1 (en) 2004-11-25
CA2450480A1 (en) 2003-01-03
HK1064666A1 (en) 2005-02-04
HUP0400368A2 (hu) 2004-08-30
RU2309156C2 (ru) 2007-10-27
DE60203290D1 (de) 2005-04-21
KR20040010762A (ko) 2004-01-31
ES2239717T3 (es) 2005-10-01

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