EA025871B9 - Ингибиторы mek и способы их применения - Google Patents

Ингибиторы mek и способы их применения

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Publication number
EA025871B9
EA025871B9 EA201400111A EA201400111A EA025871B9 EA 025871 B9 EA025871 B9 EA 025871B9 EA 201400111 A EA201400111 A EA 201400111A EA 201400111 A EA201400111 A EA 201400111A EA 025871 B9 EA025871 B9 EA 025871B9
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EA
Eurasian Patent Office
Prior art keywords
methods
compounds
mek inhibitors
same
cancer
Prior art date
Application number
EA201400111A
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English (en)
Other versions
EA201400111A1 (ru
EA025871B1 (ru
Inventor
Наинг Аай
Нил Кумар Ананд
Оуэн Джозеф Баулес
Йорг Буссениус
Симона Костанцо
Джеффри Кимо Кертис
Лариса Дубенко
Анагха Абхиджит Джоши
Эбигейл Р. Кеннеди
Энджи Инянг Ким
Елена Колтун
Жан-Клэр Лимун Манало
Ксаба Дж. Пето
Кеннет Д. Райс
Тзе Х. Тсан
Стивен Чарльз Дефина
Чарльз М. Блейзи
Original Assignee
Экселиксис, Инк.
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Application filed by Экселиксис, Инк. filed Critical Экселиксис, Инк.
Publication of EA201400111A1 publication Critical patent/EA201400111A1/ru
Publication of EA025871B1 publication Critical patent/EA025871B1/ru
Publication of EA025871B9 publication Critical patent/EA025871B9/ru

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    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Раскрываются соединения формулы I и их фармацевтически приемлемые соли и сольваты. Такие соединения являются ингибиторами MEK и являются полезными для лечения пролиферативных заболеваний, таких как рак. Также раскрываются фармацевтические композиции, содержащие такие соединения, а также способы применения соединений и композиций по настоящему изобретению для лечения рака.
EA201400111A 2005-10-07 2006-10-05 Ингибиторы mek и способы их применения EA025871B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72457805P 2005-10-07 2005-10-07
US80284006P 2006-05-23 2006-05-23

Publications (3)

Publication Number Publication Date
EA201400111A1 EA201400111A1 (ru) 2014-09-30
EA025871B1 EA025871B1 (ru) 2017-02-28
EA025871B9 true EA025871B9 (ru) 2017-08-31

Family

ID=37728416

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201691142A EA032466B1 (ru) 2005-10-07 2006-10-05 Способы получения ингибиторов mek
EA200801041A EA019983B1 (ru) 2005-10-07 2006-10-05 Ингибиторы mek и способы их применения
EA201400111A EA025871B9 (ru) 2005-10-07 2006-10-05 Ингибиторы mek и способы их применения

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EA201691142A EA032466B1 (ru) 2005-10-07 2006-10-05 Способы получения ингибиторов mek
EA200801041A EA019983B1 (ru) 2005-10-07 2006-10-05 Ингибиторы mek и способы их применения

Country Status (32)

Country Link
US (8) US7803839B2 (ru)
EP (1) EP1934174B1 (ru)
JP (8) JP5129143B2 (ru)
KR (2) KR20130058072A (ru)
CN (5) CN109053523B (ru)
AT (1) ATE504565T1 (ru)
AU (1) AU2006302415B2 (ru)
BR (1) BRPI0617165B1 (ru)
CA (3) CA3052368A1 (ru)
CY (2) CY1111670T1 (ru)
DE (1) DE602006021205D1 (ru)
DK (1) DK1934174T3 (ru)
EA (3) EA032466B1 (ru)
ES (1) ES2365070T3 (ru)
FR (1) FR16C0021I2 (ru)
GE (1) GEP20125456B (ru)
HK (2) HK1119698A1 (ru)
HR (1) HRP20110498T1 (ru)
HU (1) HUS1600021I1 (ru)
IL (5) IL189900A (ru)
LT (1) LTC1934174I2 (ru)
LU (1) LU93078I2 (ru)
MY (1) MY162174A (ru)
NL (1) NL300809I2 (ru)
NO (4) NO347091B1 (ru)
NZ (1) NZ567140A (ru)
PL (1) PL1934174T3 (ru)
PT (1) PT1934174E (ru)
RS (1) RS51782B (ru)
SI (1) SI1934174T1 (ru)
WO (1) WO2007044515A1 (ru)
ZA (1) ZA200802075B (ru)

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