BR112012022801B8 - método de identificar um indivíduo que tem câncer que é provável beneficiar-se do tratamento com uma terapia de combinação com um inibidor de raf e um segundo inibidor e uso de um inibidor de raf e um segundo inibidor para a fabricação de um medicamento para tratar câncer - Google Patents

método de identificar um indivíduo que tem câncer que é provável beneficiar-se do tratamento com uma terapia de combinação com um inibidor de raf e um segundo inibidor e uso de um inibidor de raf e um segundo inibidor para a fabricação de um medicamento para tratar câncer Download PDF

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Publication number
BR112012022801B8
BR112012022801B8 BR112012022801A BR112012022801A BR112012022801B8 BR 112012022801 B8 BR112012022801 B8 BR 112012022801B8 BR 112012022801 A BR112012022801 A BR 112012022801A BR 112012022801 A BR112012022801 A BR 112012022801A BR 112012022801 B8 BR112012022801 B8 BR 112012022801B8
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inhibitor
cancer
individual
raf
identifying
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BR112012022801A
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BR112012022801A2 (pt
BR112012022801B1 (pt
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M Johannessen Cory
A Garraway Levi
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Dana Farber Cancer Inst Inc
Broad Inst Inc
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Publication of BR112012022801A2 publication Critical patent/BR112012022801A2/pt
Publication of BR112012022801B1 publication Critical patent/BR112012022801B1/pt
Publication of BR112012022801B8 publication Critical patent/BR112012022801B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11024—Mitogen-activated protein kinase (2.7.11.24), i.e. MAPK or MAPK2 or c-Jun N-terminal kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

métodos de diagnosticar e tratar câncer em pacientes que têm ou que desenvolvem resistência a uma primeira terapia contra o câncer. um método de identificar um indivíduo que tem câncer que é provável de beneficiar-se do tratamento com uma terapia de combinação com um inibidor de raf e um segundo inibidor é fornecido. um método de tratar câncer em um indivíduo em necessidade deste é também fornecido e inclui administrar ao indivíduo uma quantidade eficaz de um inibidor raf e uma quantidade eficaz de um segundo inibidor , em que o segundo inibidor é um inibidor de mek , um inibidor de craf , um inibidor de crkl ou um inibidor de tpl2/cot. um método de identificar uma cinase alvo que confere resistência a um primeiro inibidor também é fornecido.
BR112012022801A 2010-03-09 2011-03-09 método de identificar um indivíduo que tem câncer que é provável beneficiar-se do tratamento com uma terapia de combinação com um inibidor de raf e um segundo inibidor e uso de um inibidor de raf e um segundo inibidor para a fabricação de um medicamento para tratar câncer BR112012022801B8 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US31219310P 2010-03-09 2010-03-09
US61/312,193 2010-03-09
US31251910P 2010-03-10 2010-03-10
US61/312,519 2010-03-10
US32602110P 2010-04-20 2010-04-20
US61/362,021 2010-07-07
US41556910P 2010-11-19 2010-11-19
US61/415,569 2010-11-19
PCT/US2011/027689 WO2011112678A1 (en) 2010-03-09 2011-03-09 Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy

Publications (3)

Publication Number Publication Date
BR112012022801A2 BR112012022801A2 (pt) 2017-01-10
BR112012022801B1 BR112012022801B1 (pt) 2019-10-15
BR112012022801B8 true BR112012022801B8 (pt) 2019-10-29

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BR112012022801A BR112012022801B8 (pt) 2010-03-09 2011-03-09 método de identificar um indivíduo que tem câncer que é provável beneficiar-se do tratamento com uma terapia de combinação com um inibidor de raf e um segundo inibidor e uso de um inibidor de raf e um segundo inibidor para a fabricação de um medicamento para tratar câncer

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US (3) US20130059851A1 (pt)
EP (1) EP2545187B1 (pt)
JP (1) JP5985401B2 (pt)
KR (1) KR20120139767A (pt)
CN (1) CN103038364A (pt)
AU (1) AU2011224410B2 (pt)
BR (1) BR112012022801B8 (pt)
CA (1) CA2791247C (pt)
EA (1) EA030276B1 (pt)
ES (1) ES2714875T3 (pt)
MX (1) MX343368B (pt)
WO (1) WO2011112678A1 (pt)

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CA2791247C (en) 2019-05-14
JP5985401B2 (ja) 2016-09-06
EA201290883A1 (ru) 2013-04-30
KR20120139767A (ko) 2012-12-27
WO2011112678A1 (en) 2011-09-15
CA2791247A1 (en) 2011-09-15
JP2013526843A (ja) 2013-06-27
EP2545187B1 (en) 2018-09-05
CN103038364A (zh) 2013-04-10
US20210404014A1 (en) 2021-12-30
BR112012022801B1 (pt) 2019-10-15
US20170268069A1 (en) 2017-09-21
US11078540B2 (en) 2021-08-03
EA030276B1 (ru) 2018-07-31
EP2545187A1 (en) 2013-01-16
AU2011224410B2 (en) 2015-05-28
MX2012010420A (es) 2012-11-30
AU2011224410A1 (en) 2012-09-20
US20130059851A1 (en) 2013-03-07
MX343368B (es) 2016-11-01
ES2714875T3 (es) 2019-05-30

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