BR112014024219A8 - Métodos de determinação, de otimização da eficácia terapêutica, de monitoramento, de seleção de terapia e de diagnóstico de distúrbio e kit - Google Patents

Métodos de determinação, de otimização da eficácia terapêutica, de monitoramento, de seleção de terapia e de diagnóstico de distúrbio e kit

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Publication number
BR112014024219A8
BR112014024219A8 BR112014024219A BR112014024219A BR112014024219A8 BR 112014024219 A8 BR112014024219 A8 BR 112014024219A8 BR 112014024219 A BR112014024219 A BR 112014024219A BR 112014024219 A BR112014024219 A BR 112014024219A BR 112014024219 A8 BR112014024219 A8 BR 112014024219A8
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Brazil
Prior art keywords
methods
kit
monitoring
therapeutic effectiveness
determining
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BR112014024219A
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English (en)
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BR112014024219A2 (pt
Inventor
Hedge Priti
Schmidt Maike
Yeh Ru-Fang
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Genentech Inc
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112014024219A2 publication Critical patent/BR112014024219A2/pt
Publication of BR112014024219A8 publication Critical patent/BR112014024219A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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    • A—HUMAN NECESSITIES
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K—PEPTIDES
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/515—Angiogenesic factors; Angiogenin
    • G—PHYSICS
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
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    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
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    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G01N2333/90248—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one of the donors, and incorporation of one atom of oxygen 1.14.13
    • G01N2333/90251—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one of the donors, and incorporation of one atom of oxygen 1.14.13 with a definite EC number (1.14.13.-)
    • G01N2333/90254—Nitric-oxide synthase (NOS; 1.14.13.39)

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Abstract

MÉTODO DE DETERMINAÇÃO SE O PACIENTE É PROPENSO A REAGIR A TRATAMENTO COM UM ANTAGONISTA DE VEGF, MÉTODO DE OTIMIZAÇÃO DA EFICÁCIA TERAPÊUTICA, MÉTODO DE MONITORAMENTO, MÉTODOS DE SELEÇÃO DE UMA TERAPIA, MÉTODO DE DIAGNÓSTICO DE DISTÚRBIO ANGIOGÊNICO E KIT. A presente invenção fornece métodos e composições para detectar a expressão de um ou mais biomarcadores para identificar e tratar pacientes que são propensos a reagir a terapia com antagonista de VEGF. A presente invenção também fornece kits e artigos industrializados para uso nos métodos.
BR112014024219A 2012-03-30 2013-03-14 Métodos de determinação, de otimização da eficácia terapêutica, de monitoramento, de seleção de terapia e de diagnóstico de distúrbio e kit BR112014024219A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261618199P 2012-03-30 2012-03-30
PCT/US2013/031760 WO2013148288A1 (en) 2012-03-30 2013-03-14 Diagnostic methods and compositions for treatment of cancer

Publications (2)

Publication Number Publication Date
BR112014024219A2 BR112014024219A2 (pt) 2017-06-20
BR112014024219A8 true BR112014024219A8 (pt) 2017-07-25

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BR112014024219A BR112014024219A8 (pt) 2012-03-30 2013-03-14 Métodos de determinação, de otimização da eficácia terapêutica, de monitoramento, de seleção de terapia e de diagnóstico de distúrbio e kit

Country Status (14)

Country Link
US (1) US20150056190A1 (pt)
EP (1) EP2830661A4 (pt)
JP (2) JP6335875B2 (pt)
KR (1) KR20140142719A (pt)
CN (1) CN104271157A (pt)
AU (2) AU2013240234B2 (pt)
BR (1) BR112014024219A8 (pt)
CA (1) CA2867588A1 (pt)
HK (1) HK1200739A1 (pt)
IL (1) IL234678A0 (pt)
MX (1) MX2014011582A (pt)
RU (1) RU2666627C2 (pt)
SG (2) SG10201509939PA (pt)
WO (1) WO2013148288A1 (pt)

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JP7348074B2 (ja) 2017-06-04 2023-09-20 ラパポート・ファミリー・インスティテュート・フォー・リサーチ・イン・ザ・メディカル・サイエンシーズ がん治療に対する個別化応答の予測方法およびそのキット
US12016900B2 (en) 2017-06-04 2024-06-25 Rappaport Family Institute For Research In The Medical Sciences Method of treating cancer with an immune checkpoint inhibitor in combination with another therapeutic agent
RU2701356C1 (ru) * 2018-09-18 2019-09-25 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) Способ диагностики рака молочной железы с экспрессией рецептора Her2/neu на мембране опухолевых клеток
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EP2830661A4 (en) 2016-05-18
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