AR098155A1 - Métodos para diagnosticar y tratar trastornos eosinofílicos - Google Patents
Métodos para diagnosticar y tratar trastornos eosinofílicosInfo
- Publication number
- AR098155A1 AR098155A1 ARP140103970A ARP140103970A AR098155A1 AR 098155 A1 AR098155 A1 AR 098155A1 AR P140103970 A ARP140103970 A AR P140103970A AR P140103970 A ARP140103970 A AR P140103970A AR 098155 A1 AR098155 A1 AR 098155A1
- Authority
- AR
- Argentina
- Prior art keywords
- level
- sample
- patient
- methods
- mrna
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Abstract
Se proporcionan los métodos de diagnosticar y tratar trastornos relacionados con el exceso de cantidades o actividad de eosinófilos, que incluye pero sin limitación asma. También se proporcionan los métodos de seleccionar o identificar pacientes para el tratamiento con ciertos agentes terapéuticos que son inhibidores de TH2. Reivindicación 1: Un método para predecir la respuesta de un paciente que padece de asma o de un trastorno respiratorio a una terapia que comprende un inhibidor de la vía de TH2, el método comprende: obtener una muestra biológica del paciente, medir el nivel de mARN de al menos uno, al menos dos o al menos tres marcadores en la muestra seleccionados de CSF1, MEIS2, LGALS12, IDO1, THBS4, OLIG2, ALOX15, SIGLEC8, CCL23, PYROXD2, HSD3B7, SORD, ASB2, CACNG6, GPR44, MGAT3, SLC47A1, SMPD3, CCR3, CLC, CYP4F12, y ABTB2, comparar el nivel de mARN detectado en la muestra con un nivel de referencia, y predecir que el paciente responderá a la terapia cuando el nivel de mARN medido en la muestra es elevado comparado con el nivel de referencia y predecir que el paciente no responderá a la terapia cuando el nivel de mARN medido en la muestra es reducido comparado con el nivel de referencia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361894831P | 2013-10-23 | 2013-10-23 |
Publications (1)
Publication Number | Publication Date |
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AR098155A1 true AR098155A1 (es) | 2016-05-04 |
Family
ID=52993499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140103970A AR098155A1 (es) | 2013-10-23 | 2014-10-22 | Métodos para diagnosticar y tratar trastornos eosinofílicos |
Country Status (14)
Country | Link |
---|---|
US (3) | US20170067108A1 (es) |
EP (1) | EP3060685B1 (es) |
JP (2) | JP6715767B2 (es) |
KR (1) | KR20160068802A (es) |
CN (1) | CN105849280B (es) |
AR (1) | AR098155A1 (es) |
AU (1) | AU2014340129A1 (es) |
BR (1) | BR112016008694A2 (es) |
CA (1) | CA2924873A1 (es) |
IL (1) | IL244709A0 (es) |
MX (1) | MX2016005159A (es) |
RU (1) | RU2016119425A (es) |
SG (1) | SG11201603127WA (es) |
WO (1) | WO2015061441A1 (es) |
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-
2014
- 2014-10-22 EP EP14856518.7A patent/EP3060685B1/en not_active Not-in-force
- 2014-10-22 AU AU2014340129A patent/AU2014340129A1/en not_active Abandoned
- 2014-10-22 KR KR1020167010399A patent/KR20160068802A/ko not_active Application Discontinuation
- 2014-10-22 RU RU2016119425A patent/RU2016119425A/ru not_active Application Discontinuation
- 2014-10-22 CA CA2924873A patent/CA2924873A1/en not_active Abandoned
- 2014-10-22 SG SG11201603127WA patent/SG11201603127WA/en unknown
- 2014-10-22 CN CN201480070162.0A patent/CN105849280B/zh not_active Expired - Fee Related
- 2014-10-22 WO PCT/US2014/061759 patent/WO2015061441A1/en active Application Filing
- 2014-10-22 MX MX2016005159A patent/MX2016005159A/es unknown
- 2014-10-22 BR BR112016008694A patent/BR112016008694A2/pt not_active IP Right Cessation
- 2014-10-22 JP JP2016526089A patent/JP6715767B2/ja not_active Expired - Fee Related
- 2014-10-22 AR ARP140103970A patent/AR098155A1/es unknown
-
2016
- 2016-03-22 IL IL244709A patent/IL244709A0/en unknown
- 2016-04-22 US US15/136,677 patent/US20170067108A1/en not_active Abandoned
-
2018
- 2018-10-09 US US16/155,706 patent/US20190024178A1/en not_active Abandoned
-
2019
- 2019-11-01 US US16/671,903 patent/US20200165679A1/en not_active Abandoned
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2020
- 2020-06-08 JP JP2020099159A patent/JP2020178692A/ja active Pending
Also Published As
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JP6715767B2 (ja) | 2020-07-01 |
US20190024178A1 (en) | 2019-01-24 |
IL244709A0 (en) | 2016-04-21 |
AU2014340129A1 (en) | 2016-05-26 |
CN105849280A (zh) | 2016-08-10 |
US20200165679A1 (en) | 2020-05-28 |
JP2020178692A (ja) | 2020-11-05 |
BR112016008694A2 (pt) | 2017-10-03 |
SG11201603127WA (en) | 2016-05-30 |
US20170067108A1 (en) | 2017-03-09 |
EP3060685A1 (en) | 2016-08-31 |
RU2016119425A3 (es) | 2018-05-30 |
EP3060685B1 (en) | 2019-05-01 |
EP3060685A4 (en) | 2017-10-18 |
CN105849280B (zh) | 2020-11-06 |
WO2015061441A1 (en) | 2015-04-30 |
KR20160068802A (ko) | 2016-06-15 |
MX2016005159A (es) | 2016-07-05 |
JP2017501680A (ja) | 2017-01-19 |
CA2924873A1 (en) | 2015-04-30 |
RU2016119425A (ru) | 2017-11-28 |
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