BR112015005583A2 - método para o diagnóstico de um fenótipo molecular de um paciente que sofre de uma doença associada à inflamação crônica - Google Patents

método para o diagnóstico de um fenótipo molecular de um paciente que sofre de uma doença associada à inflamação crônica

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Publication number
BR112015005583A2
BR112015005583A2 BR112015005583A BR112015005583A BR112015005583A2 BR 112015005583 A2 BR112015005583 A2 BR 112015005583A2 BR 112015005583 A BR112015005583 A BR 112015005583A BR 112015005583 A BR112015005583 A BR 112015005583A BR 112015005583 A2 BR112015005583 A2 BR 112015005583A2
Authority
BR
Brazil
Prior art keywords
chronic inflammation
diagnosing
molecular phenotype
patient suffering
disease associated
Prior art date
Application number
BR112015005583A
Other languages
English (en)
Inventor
Turowska Agnieszka
Bille Joachim
Original Assignee
Sterna Biologicals Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterna Biologicals Gmbh & Co Kg filed Critical Sterna Biologicals Gmbh & Co Kg
Publication of BR112015005583A2 publication Critical patent/BR112015005583A2/pt

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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7095—Inflammation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
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  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
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  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biophysics (AREA)
  • Epidemiology (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

resumo da patente de invenção para: “método para o diagnóstico de um fenótipo molecular de um paciente que sofre de uma doença associada à inflamação crônica”. a inflamação crônica constitui um problema médico crescente de elevada relevância socioeconômica. a presente invenção diz respeito a um método e a um kit destinados ao diagnóstico de um fenótipo molecular de um paciente que sofre de uma doença acompanhada de inflamação crônica, e a um medicamento para o tratamento de tal paciente. para tal, procede-se a medição da expressão dos genes gata-3 e/ou tbet num isolado biológico, utilizando-se em associação a um fenótipo molecular da doença.
BR112015005583A 2012-09-14 2013-09-04 método para o diagnóstico de um fenótipo molecular de um paciente que sofre de uma doença associada à inflamação crônica BR112015005583A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12184500.2A EP2708898A1 (de) 2012-09-14 2012-09-14 Verfahren zur Diagnose eines molekularen Phänotyps eines an einer mit chronischen Entzündungen einhergehenden Erkrankung leidenden Patienten
PCT/EP2013/068317 WO2014040891A2 (de) 2012-09-14 2013-09-04 Verfahren zur diagnose eines molekularen phänotyps eines an einer mit chronischen entzündungen einhergehenden erkrankung leidenden patienten

Publications (1)

Publication Number Publication Date
BR112015005583A2 true BR112015005583A2 (pt) 2017-08-08

Family

ID=46963488

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015005583A BR112015005583A2 (pt) 2012-09-14 2013-09-04 método para o diagnóstico de um fenótipo molecular de um paciente que sofre de uma doença associada à inflamação crônica

Country Status (9)

Country Link
US (2) US9791454B2 (pt)
EP (1) EP2708898A1 (pt)
JP (2) JP6401163B2 (pt)
KR (1) KR102157768B1 (pt)
AU (2) AU2013314510A1 (pt)
BR (1) BR112015005583A2 (pt)
CA (2) CA2888860C (pt)
RU (1) RU2672595C2 (pt)
WO (1) WO2014040891A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3093022B1 (en) * 2015-05-15 2019-08-07 Sterna Biologicals GmbH & Co. KG Gata-3 inhibitors for use in the treatment of th2-driven asthma
US10905710B2 (en) 2016-05-24 2021-02-02 Emory University Particles with RNA cleaving nucleobase polymers and uses for managing inflammatory disorders
EP3501607A1 (de) * 2017-12-22 2019-06-26 Sterna Biologicals GmbH & Co. KG Zusammensetzung zur behandlung eines an einer mit chronischen entzündungen einhergehenden atemwegserkrankung leidenden patienten sowie herstellungsverfahren und verwendung der zusammensetzung
EP3514235B8 (de) * 2018-01-18 2024-02-14 Sterna Biologicals GmbH Zusammensetzung zur behandlung eines an colitis ulcerosa leidenden patienten sowie verwendung der zusammensetzung als arzneimittel
EP3603617A1 (de) * 2018-07-30 2020-02-05 Sterna Biologicals GmbH & Co. KG Aerosolerzeugungseinrichtung zur inhalativen verabreichung einer antisense-molekül-haltigen zusammensetzung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10346487A1 (de) * 2003-10-02 2005-05-12 Transmit Technologietransfer Verfahren zur Herstellung eines Zell- und/oder Gewebe- und/oder Krankheitsphasen-spezifischen Arzneimittels
US8853264B2 (en) * 2005-01-07 2014-10-07 Newtree Industry Co., Ltd. Use of lignan compounds for treating or preventing inflammatory disease
WO2008021532A2 (en) 2006-08-17 2008-02-21 University Of Chicago Treatment of inflammatory diseases
EP2227232A1 (en) * 2007-12-07 2010-09-15 Fibrogen, Inc. Methods for inhibiting t helper cell differentiation
CN112481367A (zh) 2008-03-31 2021-03-12 健泰科生物技术公司 用于治疗和诊断哮喘的组合物和方法
JP2012520685A (ja) * 2009-03-19 2012-09-10 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いたＧＡＴＡ結合タンパク質３（ＧＡＴＡ３）遺伝子発現のＲＮＡ干渉媒介性阻害
EP2460880B1 (en) * 2009-07-29 2014-11-19 Sysmex Corporation Marker and reagent for detection of human il-17-producing helper t cells, and method for detection of human il-17-producing helper t cells

Also Published As

Publication number Publication date
US20180031571A1 (en) 2018-02-01
AU2019204108A1 (en) 2019-07-04
JP2015531482A (ja) 2015-11-02
CA2888860C (en) 2023-07-18
US9791454B2 (en) 2017-10-17
JP2019007977A (ja) 2019-01-17
AU2019204108B2 (en) 2021-11-25
EP2708898A1 (de) 2014-03-19
KR20150064084A (ko) 2015-06-10
JP6401163B2 (ja) 2018-10-03
US10591489B2 (en) 2020-03-17
JP6662969B2 (ja) 2020-03-11
WO2014040891A2 (de) 2014-03-20
RU2672595C2 (ru) 2018-11-16
WO2014040891A3 (de) 2014-05-30
RU2015112894A (ru) 2016-11-10
CA2888860A1 (en) 2014-03-20
CA3199111A1 (en) 2014-03-20
AU2013314510A1 (en) 2015-04-09
KR102157768B1 (ko) 2020-09-21
US20150260728A1 (en) 2015-09-17

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: STERNA BIOLOGICALS GMBH AND CO. KG (DE)

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]