BR112017025995A2 - inibidor de igfbp3, composição farmacêutica para uso no tratamento e/ou prevenção de um distúrbio intestinal, método para o diagnóstico de um distúrbio intestinal em um indivíduo e kit para o diagnóstico de um distúrbio intestinal - Google Patents
inibidor de igfbp3, composição farmacêutica para uso no tratamento e/ou prevenção de um distúrbio intestinal, método para o diagnóstico de um distúrbio intestinal em um indivíduo e kit para o diagnóstico de um distúrbio intestinalInfo
- Publication number
- BR112017025995A2 BR112017025995A2 BR112017025995-8A BR112017025995A BR112017025995A2 BR 112017025995 A2 BR112017025995 A2 BR 112017025995A2 BR 112017025995 A BR112017025995 A BR 112017025995A BR 112017025995 A2 BR112017025995 A2 BR 112017025995A2
- Authority
- BR
- Brazil
- Prior art keywords
- intestinal disorder
- diagnosis
- igfbp3
- inhibitor
- prevention
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4745—Insulin-like growth factor binding protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15170679.3 | 2015-06-04 | ||
EP15170679 | 2015-06-04 | ||
PCT/EP2016/062790 WO2016193496A1 (en) | 2015-06-04 | 2016-06-06 | Igfbp3 and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017025995A2 true BR112017025995A2 (pt) | 2018-08-14 |
Family
ID=53365866
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017025995-8A BR112017025995A2 (pt) | 2015-06-04 | 2016-06-06 | inibidor de igfbp3, composição farmacêutica para uso no tratamento e/ou prevenção de um distúrbio intestinal, método para o diagnóstico de um distúrbio intestinal em um indivíduo e kit para o diagnóstico de um distúrbio intestinal |
Country Status (17)
Country | Link |
---|---|
US (2) | US10682391B2 (pt) |
EP (1) | EP3302520B1 (pt) |
JP (1) | JP6937745B2 (pt) |
KR (1) | KR102141446B1 (pt) |
CN (1) | CN107921094B (pt) |
AU (1) | AU2016272044B2 (pt) |
BR (1) | BR112017025995A2 (pt) |
CA (1) | CA2986080C (pt) |
EA (1) | EA201792669A1 (pt) |
ES (1) | ES2834823T3 (pt) |
HK (1) | HK1249447A1 (pt) |
IL (1) | IL256020B (pt) |
MX (1) | MX2017015700A (pt) |
NZ (1) | NZ738100A (pt) |
PL (1) | PL3302520T3 (pt) |
WO (1) | WO2016193496A1 (pt) |
ZA (1) | ZA201708076B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016272045B2 (en) | 2015-06-04 | 2018-04-19 | Ospedale San Raffaele Srl | Inhibitor of IGFBP3/TMEM219 axis and diabetes |
KR102141446B1 (ko) | 2015-06-04 | 2020-08-06 | 오스페달레 산 라파엘 에스.알.엘. | Igfbp3 및 이의 용도 |
EP3534932A4 (en) | 2016-11-01 | 2020-09-09 | Virginia Commonwealth University | TREATMENT OF DISEASES ASSOCIATED WITH IGFB3 AND ITS RECEPTOR |
EP3632929A1 (en) | 2018-10-02 | 2020-04-08 | Ospedale San Raffaele S.r.l. | Antibodies and uses thereof |
WO2021014351A1 (en) * | 2019-07-23 | 2021-01-28 | Novartis Ag | Treatment comprising sglt inhibitors, e.g. sglt 1/2 inhibitors |
JP2023501229A (ja) | 2019-11-15 | 2023-01-18 | エンテラ・エッセ・エッレ・エッレ | Tmem219抗体及びその治療的使用 |
WO2021099574A1 (en) | 2019-11-21 | 2021-05-27 | Enthera S.R.L. | Igfbp3 antibodies and therapeutic uses thereof |
CN117451995A (zh) * | 2021-12-06 | 2024-01-26 | 上海市精神卫生中心(上海市心理咨询培训中心) | 用于预测应激后精神心理症状发生的免疫检测试剂盒及应用 |
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US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US5215534A (en) | 1991-12-02 | 1993-06-01 | Lawrence De Harde | Safety syringe system |
GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
EP0854884A1 (en) | 1996-04-17 | 1998-07-29 | Neurocrine Biosciences, Inc. | Ligand inhibitors of insulin-like growth factor binding proteins and methods of use therefor |
US6066464A (en) | 1996-12-10 | 2000-05-23 | Diagnostic Systems Laboratories, Inc. | Immunoassay of IGF family of peptides, their binding proteins and related molecules in dried whole blood filter paper spots |
DE69830315T2 (de) | 1997-06-24 | 2006-02-02 | Genentech Inc., San Francisco | Galactosylierte glykoproteine enthaltende zusammensetzungen und verfahren zur deren herstellung |
ATE419009T1 (de) | 1997-10-31 | 2009-01-15 | Genentech Inc | Methoden und zusammensetzungen bestehend aus glykoprotein-glykoformen |
AU3657899A (en) | 1998-04-20 | 1999-11-08 | James E. Bailey | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
US6448086B1 (en) | 2000-01-18 | 2002-09-10 | Diagnostic Systems Laboratories, Inc. | Insulin-like growth factor system and cancer |
EP1290162A4 (en) | 2000-05-17 | 2005-08-17 | Univ Oregon Health Sciences | INDUCTION OF APOPTOSIS AND INHIBITION OF CELL GROWTH BY PROTEIN 4.33 (P4.33) |
EP1332209B1 (en) | 2000-09-08 | 2009-11-11 | Universität Zürich | Collections of repeat proteins comprising repeat modules |
AU2002232593A1 (en) | 2000-10-27 | 2002-05-06 | Oregon Health And Science University | Novel mutant igbp-3 molecules that do not bind to igfs, but retain their ability to functionally bind igfbp-3 receptor |
EP2341060B1 (en) | 2000-12-12 | 2019-02-20 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
NZ592087A (en) | 2001-08-03 | 2012-11-30 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
ES2326964T3 (es) | 2001-10-25 | 2009-10-22 | Genentech, Inc. | Composiciones de glicoproteina. |
US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
EA036531B1 (ru) | 2003-11-05 | 2020-11-19 | Роше Гликарт Аг | Гуманизированное антитело типа ii к cd20 (варианты), фармацевтическая композиция, содержащая эти варианты антитела, и их применение |
EP1791565B1 (en) | 2004-09-23 | 2016-04-20 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
US20090170133A1 (en) * | 2005-04-19 | 2009-07-02 | Irena Kirman | Intact IGFBP-3 as a Colon Cancer Risk Factor in Patients With Inflammatory Bowel Disease |
RU2515108C2 (ru) | 2005-08-19 | 2014-05-10 | Эббви Инк | Иммуноглобулин с двойными вариабельными доменами и его применения |
WO2008153788A2 (en) | 2007-05-30 | 2008-12-18 | Albert Einstein College Of Medicine Of Yeshiva University | Treatment of type 2 diabetes, metabolic syndrome, myocardial injury and neurodegeneration with humanin and analogs thereof |
ES2617777T5 (es) | 2010-04-23 | 2022-10-13 | Hoffmann La Roche | Producción de proteínas heteromultiméricas |
US9427531B2 (en) | 2010-06-28 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Auto-injector |
CA2825357C (en) | 2011-02-24 | 2018-07-10 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Igfbp-3 derivatives and uses thereof |
CA2858389A1 (en) * | 2011-12-15 | 2013-06-20 | The Royal Institution For The Advancement Of Learning/Mcgill University | Soluble igf receptor fc fusion proteins and uses thereof |
WO2013152989A2 (en) | 2012-04-10 | 2013-10-17 | Eth Zurich | Biomarker assay and uses thereof for diagnosis, therapy selection, and prognosis of cancer |
US9248242B2 (en) | 2012-04-20 | 2016-02-02 | Safety Syringes, Inc. | Anti-needle stick safety device for injection device |
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US20160011207A1 (en) | 2012-12-07 | 2016-01-14 | Virginia Commonwealth University | Diagnosis and therapy of chronic inflammation-induced disorders |
KR102500071B1 (ko) | 2014-10-23 | 2023-02-14 | 얀센 파마슈티카 엔.브이. | Nik 억제제로서의 신규 화합물 |
AU2016272045B2 (en) | 2015-06-04 | 2018-04-19 | Ospedale San Raffaele Srl | Inhibitor of IGFBP3/TMEM219 axis and diabetes |
KR102141446B1 (ko) | 2015-06-04 | 2020-08-06 | 오스페달레 산 라파엘 에스.알.엘. | Igfbp3 및 이의 용도 |
-
2016
- 2016-06-06 KR KR1020187000310A patent/KR102141446B1/ko active IP Right Grant
- 2016-06-06 NZ NZ73810016A patent/NZ738100A/en not_active IP Right Cessation
- 2016-06-06 MX MX2017015700A patent/MX2017015700A/es unknown
- 2016-06-06 CA CA2986080A patent/CA2986080C/en active Active
- 2016-06-06 US US15/579,573 patent/US10682391B2/en active Active
- 2016-06-06 EA EA201792669A patent/EA201792669A1/ru unknown
- 2016-06-06 JP JP2018515354A patent/JP6937745B2/ja active Active
- 2016-06-06 AU AU2016272044A patent/AU2016272044B2/en active Active
- 2016-06-06 ES ES16728910T patent/ES2834823T3/es active Active
- 2016-06-06 WO PCT/EP2016/062790 patent/WO2016193496A1/en active Application Filing
- 2016-06-06 CN CN201680045710.3A patent/CN107921094B/zh active Active
- 2016-06-06 EP EP16728910.7A patent/EP3302520B1/en active Active
- 2016-06-06 BR BR112017025995-8A patent/BR112017025995A2/pt not_active IP Right Cessation
- 2016-06-06 PL PL16728910.7T patent/PL3302520T3/pl unknown
-
2017
- 2017-11-28 ZA ZA2017/08076A patent/ZA201708076B/en unknown
- 2017-11-30 IL IL256020A patent/IL256020B/en unknown
-
2018
- 2018-07-16 HK HK18109166.9A patent/HK1249447A1/zh unknown
-
2020
- 2020-04-22 US US16/855,992 patent/US20200316168A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2018520212A (ja) | 2018-07-26 |
US20200316168A1 (en) | 2020-10-08 |
HK1249447A1 (zh) | 2018-11-02 |
WO2016193496A9 (en) | 2020-02-20 |
AU2016272044B2 (en) | 2018-12-06 |
NZ738100A (en) | 2019-09-27 |
EA201792669A1 (ru) | 2018-06-29 |
IL256020A (en) | 2018-01-31 |
JP6937745B2 (ja) | 2021-09-22 |
ES2834823T3 (es) | 2021-06-18 |
US20180172708A1 (en) | 2018-06-21 |
EP3302520A1 (en) | 2018-04-11 |
CN107921094B (zh) | 2022-03-01 |
WO2016193496A1 (en) | 2016-12-08 |
KR20180019152A (ko) | 2018-02-23 |
MX2017015700A (es) | 2018-11-09 |
CN107921094A (zh) | 2018-04-17 |
CA2986080C (en) | 2023-12-05 |
US10682391B2 (en) | 2020-06-16 |
AU2016272044A1 (en) | 2018-01-04 |
ZA201708076B (en) | 2018-11-28 |
PL3302520T4 (pl) | 2021-03-22 |
IL256020B (en) | 2021-09-30 |
KR102141446B1 (ko) | 2020-08-06 |
CA2986080A1 (en) | 2016-12-08 |
EP3302520B1 (en) | 2020-08-05 |
PL3302520T3 (pl) | 2021-03-22 |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2673 DE 29-03-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |