BR112015015131A2 - método, aparelho, mídia de armazenamento não transitório, programa de computador, e produto - Google Patents

método, aparelho, mídia de armazenamento não transitório, programa de computador, e produto

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Publication number
BR112015015131A2
BR112015015131A2 BR112015015131A BR112015015131A BR112015015131A2 BR 112015015131 A2 BR112015015131 A2 BR 112015015131A2 BR 112015015131 A BR112015015131 A BR 112015015131A BR 112015015131 A BR112015015131 A BR 112015015131A BR 112015015131 A2 BR112015015131 A2 BR 112015015131A2
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transient storage
computer program
product
storage media
methods
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BR112015015131A
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English (en)
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Jan Van Ooijen Hendrik
Arnold Van De Wiel Paul
Franciscus Johannes Verhaegh Wilhelmus
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Koninklijke Philips Nv
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Publication of BR112015015131A2 publication Critical patent/BR112015015131A2/pt

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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00—Computing arrangements using knowledge-based models
    • G06N5/04—Inference or reasoning models
    • G06N5/048—Fuzzy inferencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Theoretical Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Software Systems (AREA)
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  • Microbiology (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
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  • Data Mining & Analysis (AREA)
  • Evolutionary Computation (AREA)
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  • Automation & Control Theory (AREA)
  • Computational Linguistics (AREA)
  • Fuzzy Systems (AREA)
  • Computing Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

resumo método, aparelho, mídia de armazenamento não transitório, programa de computador, e produto o presente pedido refere-se principalmente a métodos específicos para inferir a atividade de uma via de sinalização celular em um tecido e/ou em células de um paciente médico com base em ao menos um nível de expressão de um ou mais genes alvo da via de sinalização celular medida em uma amostra extraída do tecido e/ou das células do paciente médico, um aparelho compreendendo um processador digital configurado para executar tais métodos e uma mídia de armazenamento não transitório que armazena instruções que são executáveis por um dispositivo de processamento digital para executar tais métodos. 1/1
BR112015015131A 2012-12-26 2013-12-18 método, aparelho, mídia de armazenamento não transitório, programa de computador, e produto BR112015015131A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261745839P 2012-12-26 2012-12-26
PCT/IB2013/061066 WO2014102668A2 (en) 2012-12-26 2013-12-18 Assessment of cellular signaling pathway activity using linear combination(s) of target gene expressions;

Publications (1)

Publication Number Publication Date
BR112015015131A2 true BR112015015131A2 (pt) 2017-07-11

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Family Applications (1)

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BR112015015131A BR112015015131A2 (pt) 2012-12-26 2013-12-18 método, aparelho, mídia de armazenamento não transitório, programa de computador, e produto

Country Status (13)

Country Link
US (2) US11306360B2 (pt)
EP (1) EP2938745B1 (pt)
JP (2) JP6449779B2 (pt)
KR (1) KR102279844B1 (pt)
CN (2) CN111961726A (pt)
AU (2) AU2013368945B2 (pt)
BR (1) BR112015015131A2 (pt)
CA (1) CA2896414C (pt)
DK (1) DK2938745T3 (pt)
ES (1) ES2878196T3 (pt)
MX (1) MX2015008177A (pt)
RU (1) RU2721130C2 (pt)
WO (1) WO2014102668A2 (pt)

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CA2923092C (en) 2014-01-03 2019-12-17 Koninklijke Philips N.V. Assessment of the pi3k cellular signaling pathway activity using mathematical modelling of target gene expression
JP7065610B6 (ja) * 2014-10-24 2022-06-06 コーニンクレッカ フィリップス エヌ ヴェ 複数の細胞シグナル伝達経路活性を用いる治療応答の医学的予後及び予測
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RU2019100441A (ru) * 2016-06-13 2020-07-14 Конинклейке Филипс Н.В. Способ логического вывода об активности транскрипционного фактора пути сигнальной трансдукции у субъекта
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EP3461915A1 (en) * 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat1/2 cellular signaling pathway activity using mathematical modelling of target gene expression
JP7257405B2 (ja) 2017-10-02 2023-04-13 コーニンクレッカ フィリップス エヌ ヴェ 免疫細胞型及び免疫応答の機能状況の決定
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EP3502279A1 (en) * 2017-12-20 2019-06-26 Koninklijke Philips N.V. Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression
CN108187050A (zh) * 2018-01-18 2018-06-22 石河子大学 抑制食管癌细胞增殖的药物
CA3109090A1 (en) 2018-08-17 2020-02-20 F. Hoffmann-La Roche Ag Diagnostic and therapeutic methods for the treatment of breast cancer
CN113785075A (zh) 2019-05-03 2021-12-10 皇家飞利浦有限公司 高级别浆液性卵巢癌的预后方法
EP3812474A1 (en) 2019-10-22 2021-04-28 Koninklijke Philips N.V. Methods of prognosis in high-grade serous ovarian cancer
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EP3835433A1 (en) 2019-12-12 2021-06-16 Koninklijke Philips N.V. Notch signaling pathway activity as prognostic marker in bladder cancer
CN111166884B (zh) * 2020-01-15 2021-12-03 广州中医药大学第一附属医院 Foxf1基因在制备用于骨质疏松症药物中的应用
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EP3974540A1 (en) 2020-09-25 2022-03-30 Koninklijke Philips N.V. Method for predicting immunotherapy resistance
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CN112466403B (zh) * 2020-12-31 2022-06-14 广州基迪奥生物科技有限公司 一种细胞通讯分析方法及系统
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RU2015131009A (ru) 2017-01-30
AU2020202706B2 (en) 2022-06-16
JP6721665B2 (ja) 2020-07-15
MX2015008177A (es) 2015-09-16
AU2013368945B2 (en) 2020-01-23
US20230030858A1 (en) 2023-02-02
WO2014102668A2 (en) 2014-07-03
ES2878196T3 (es) 2021-11-18
EP2938745B1 (en) 2020-10-07
CN111961726A (zh) 2020-11-20
US20150347672A1 (en) 2015-12-03
CN105074005A (zh) 2015-11-18
CA2896414C (en) 2023-06-20
KR20150100896A (ko) 2015-09-02
AU2013368945A1 (en) 2015-08-13
RU2721130C2 (ru) 2020-05-18
WO2014102668A3 (en) 2014-08-21
CA2896414A1 (en) 2014-07-03
EP2938745A2 (en) 2015-11-04
AU2020202706A1 (en) 2020-05-14
US11306360B2 (en) 2022-04-19
KR102279844B1 (ko) 2021-07-21
JP2016509472A (ja) 2016-03-31
JP2019076096A (ja) 2019-05-23
DK2938745T3 (da) 2020-11-30
JP6449779B2 (ja) 2019-01-09

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