CY1118566T1 - Διαγνωση με χρηση ιντερφερονης τυπου 1 - Google Patents

Διαγνωση με χρηση ιντερφερονης τυπου 1

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Publication number
CY1118566T1
CY1118566T1 CY20171100112T CY171100112T CY1118566T1 CY 1118566 T1 CY1118566 T1 CY 1118566T1 CY 20171100112 T CY20171100112 T CY 20171100112T CY 171100112 T CY171100112 T CY 171100112T CY 1118566 T1 CY1118566 T1 CY 1118566T1
Authority
CY
Cyprus
Prior art keywords
ifnα
activated
methods
expression profiles
marker expression
Prior art date
Application number
CY20171100112T
Other languages
English (en)
Inventor
Brandon Higgs
Wei Zhu
Chris Morehouse
Barbara White
Bahija Jallal
Yihong Yao
Original Assignee
Medimmune, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune, Llc filed Critical Medimmune, Llc
Publication of CY1118566T1 publication Critical patent/CY1118566T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Η παρούσα γνωστοποίηση αναφέρεται σε προφίλ έκφρασης φαρμακοδυναμικού δείκτη, κιτ, και μεθόδους που ενεργοποιούνται από την IFN τύπου-Ι και την IFNα, για την αναγνώριση τέτοιων προφίλ έκφρασης φαρμακοδυναμικού δείκτη που ενεργοποιούνται από την IFNα. Τα προφίλ έκφρασης φαρμακοδυναμικού δείκτη που ενεργοποιούνται από την IFN τύπου-Ι και την IFNα μπορεί επίσης να χρησιμοποιηθούν σε, για παράδειγμα, μεθόδους θεραπείας ασθενών που πάσχουν από μία διαταραχή που επηρεάζεται από την IFN τύπου-Ι ή την IFNα, μεθόδους παρακολούθησης της εξέλιξης της νόσου ασθενούς που λαμβάνει θεραπεία με θεραπευτικό παράγοντα που ρυθμίζει την δράση της ιντερφερόνης τύπου 1, αναγνώρισης ασθενών ως υποψηφίων να λάβουν μία θεραπεία που δεσμεύει και εξουδετερώνει την δράση της IFNα, και στην διάγνωση ή παροχή μίας πρόγνωσης σε ασθενείς που πάσχουν από διαταραχές που ενεργοποιούνται από την IFNα.
CY20171100112T 2009-09-03 2017-01-26 Διαγνωση με χρηση ιντερφερονης τυπου 1 CY1118566T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23963009P 2009-09-03 2009-09-03
PCT/US2010/047721 WO2011028933A1 (en) 2009-09-03 2010-09-02 Type 1 interferon diagnostic

Publications (1)

Publication Number Publication Date
CY1118566T1 true CY1118566T1 (el) 2017-07-12

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Country Status (23)

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US (3) US20120251546A1 (el)
EP (1) EP2473636B1 (el)
JP (2) JP5727484B2 (el)
KR (1) KR20120101340A (el)
CN (1) CN102753704A (el)
AU (1) AU2010289383B2 (el)
BR (1) BR112012004781A2 (el)
CA (1) CA2772921A1 (el)
CY (1) CY1118566T1 (el)
DK (1) DK2473636T3 (el)
ES (1) ES2613055T3 (el)
HR (1) HRP20170091T1 (el)
HU (1) HUE032917T2 (el)
LT (1) LT2473636T (el)
ME (1) ME02599B (el)
MX (1) MX2012002640A (el)
PL (1) PL2473636T3 (el)
PT (1) PT2473636T (el)
RS (1) RS55641B1 (el)
RU (1) RU2012112802A (el)
SI (1) SI2473636T1 (el)
SM (1) SMT201700063B (el)
WO (1) WO2011028933A1 (el)

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Also Published As

Publication number Publication date
RU2012112802A (ru) 2013-10-10
EP2473636A4 (en) 2013-02-27
KR20120101340A (ko) 2012-09-13
PL2473636T3 (pl) 2017-05-31
CA2772921A1 (en) 2011-03-10
JP2013503642A (ja) 2013-02-04
US20150191788A1 (en) 2015-07-09
DK2473636T3 (en) 2017-02-06
CN102753704A (zh) 2012-10-24
ME02599B (me) 2017-06-20
EP2473636B1 (en) 2016-10-26
BR112012004781A2 (pt) 2017-02-14
EP2473636A1 (en) 2012-07-11
US20120251546A1 (en) 2012-10-04
LT2473636T (lt) 2017-02-10
HUE032917T2 (hu) 2017-11-28
JP2015147788A (ja) 2015-08-20
US20160024205A1 (en) 2016-01-28
RS55641B1 (sr) 2017-06-30
WO2011028933A1 (en) 2011-03-10
SMT201700063B (it) 2017-03-08
SI2473636T1 (sl) 2017-04-26
HRP20170091T1 (hr) 2017-03-24
ES2613055T3 (es) 2017-05-22
AU2010289383B2 (en) 2015-04-16
AU2010289383A1 (en) 2012-04-19
PT2473636T (pt) 2017-02-06
JP5727484B2 (ja) 2015-06-03
MX2012002640A (es) 2012-06-25

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