EA201290883A1 - Способы диагностики и лечения рака у пациентов, у которых имеется или развивается резистентность к первой терапии рака - Google Patents

Способы диагностики и лечения рака у пациентов, у которых имеется или развивается резистентность к первой терапии рака

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Publication number
EA201290883A1
EA201290883A1 EA201290883A EA201290883A EA201290883A1 EA 201290883 A1 EA201290883 A1 EA 201290883A1 EA 201290883 A EA201290883 A EA 201290883A EA 201290883 A EA201290883 A EA 201290883A EA 201290883 A1 EA201290883 A1 EA 201290883A1
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EA
Eurasian Patent Office
Prior art keywords
inhibitor
cancer
treatment
diagnostics
patients
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Application number
EA201290883A
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English (en)
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EA030276B1 (ru
Inventor
Леви А. Гаррауэй
Кори М. Йоханнессен
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Дана-Фарбер Кэнсер Инститьют, Инк.
Дзе Брод Инститьют, Инк.
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Application filed by Дана-Фарбер Кэнсер Инститьют, Инк., Дзе Брод Инститьют, Инк. filed Critical Дана-Фарбер Кэнсер Инститьют, Инк.
Publication of EA201290883A1 publication Critical patent/EA201290883A1/ru
Publication of EA030276B1 publication Critical patent/EA030276B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11024—Mitogen-activated protein kinase (2.7.11.24), i.e. MAPK or MAPK2 or c-Jun N-terminal kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

Обеспечивается способ идентификации индивида, страдающего раком, который, вероятно, будет иметь пользу от лечения комбинированной терапией ингибитором RAF и вторым ингибитором. Также обеспечивается способ лечения рака у индивида, нуждающегося в этом, и он включает введение индивиду эффективного количества ингибитора RAF и эффективного количества второго ингибитора, где второй ингибитор представляет ингибитор МЕК, ингибитор CRAF, ингибитор CrkL или ингибитор TPL2/COT. Также обеспечивается способ идентификации киназы-мишени, которая придает резистентность к первому ингибитору.
EA201290883A 2010-03-09 2011-03-09 Способы идентификации страдающих раком пациентов и лечения рака у пациентов, у которых имеется или развивается резистентность к первой терапии рака EA030276B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31219310P 2010-03-09 2010-03-09
US31251910P 2010-03-10 2010-03-10
US32602110P 2010-04-20 2010-04-20
US41556910P 2010-11-19 2010-11-19
PCT/US2011/027689 WO2011112678A1 (en) 2010-03-09 2011-03-09 Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy

Publications (2)

Publication Number Publication Date
EA201290883A1 true EA201290883A1 (ru) 2013-04-30
EA030276B1 EA030276B1 (ru) 2018-07-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290883A EA030276B1 (ru) 2010-03-09 2011-03-09 Способы идентификации страдающих раком пациентов и лечения рака у пациентов, у которых имеется или развивается резистентность к первой терапии рака

Country Status (12)

Country Link
US (3) US20130059851A1 (ru)
EP (1) EP2545187B1 (ru)
JP (1) JP5985401B2 (ru)
KR (1) KR20120139767A (ru)
CN (1) CN103038364A (ru)
AU (1) AU2011224410B2 (ru)
BR (1) BR112012022801B8 (ru)
CA (1) CA2791247C (ru)
EA (1) EA030276B1 (ru)
ES (1) ES2714875T3 (ru)
MX (1) MX343368B (ru)
WO (1) WO2011112678A1 (ru)

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KR20120139767A (ko) 2012-12-27
WO2011112678A1 (en) 2011-09-15
CA2791247A1 (en) 2011-09-15
JP2013526843A (ja) 2013-06-27
BR112012022801B8 (pt) 2019-10-29
EP2545187B1 (en) 2018-09-05
CN103038364A (zh) 2013-04-10
US20210404014A1 (en) 2021-12-30
BR112012022801B1 (pt) 2019-10-15
US20170268069A1 (en) 2017-09-21
US11078540B2 (en) 2021-08-03
EA030276B1 (ru) 2018-07-31
EP2545187A1 (en) 2013-01-16
AU2011224410B2 (en) 2015-05-28
MX2012010420A (es) 2012-11-30
AU2011224410A1 (en) 2012-09-20
US20130059851A1 (en) 2013-03-07
MX343368B (es) 2016-11-01
ES2714875T3 (es) 2019-05-30

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