GEP20043223B - Quinolinyl Propyl Piperidine Derivatives and Their Use as Antibacterial Agents - Google Patents

Quinolinyl Propyl Piperidine Derivatives and Their Use as Antibacterial Agents

Info

Publication number
GEP20043223B
GEP20043223B GEAP20006413A GEAP2000006413A GEP20043223B GE P20043223 B GEP20043223 B GE P20043223B GE AP20006413 A GEAP20006413 A GE AP20006413A GE AP2000006413 A GEAP2000006413 A GE AP2000006413A GE P20043223 B GEP20043223 B GE P20043223B
Authority
GE
Georgia
Prior art keywords
quinolinyl
piperidine derivatives
antibacterial agents
propyl piperidine
hydrogen
Prior art date
Application number
GEAP20006413A
Inventor
Cheve, (Fr) Michel
Mignani, (Fr) Serge
Carry, (Fr) Jean-Christophe
Malleron, (Fr) Jean-Luc
Fabrice Viviani (Fr)
Ahmad Youssef El (Fr)
Ever, (Fr) Michel
Tabart, (Fr) Michel
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of GEP20043223B publication Critical patent/GEP20043223B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1. Technical Result Increase in treatment efficiency. 2. Essence Quinolinyl propyl piperidine derivatives of formula wherein R1 is hydrogen or halogen atom; or hydroxyl R'1 is hydrogen and may represent halogen atom when R1 is also hydrogen atom. R0 is a hydrogen atom. These derivatives are antimicrobial agents. 3. Field of Application Medicine.
GEAP20006413A 1999-09-17 2000-09-14 Quinolinyl Propyl Piperidine Derivatives and Their Use as Antibacterial Agents GEP20043223B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9911679A FR2798656B1 (en) 1999-09-17 1999-09-17 DERIVATIVES OF QUINOLYL PROPYL PIPERIDINE, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
GEP20043223B true GEP20043223B (en) 2004-04-26

Family

ID=9549990

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP20006413A GEP20043223B (en) 1999-09-17 2000-09-14 Quinolinyl Propyl Piperidine Derivatives and Their Use as Antibacterial Agents

Country Status (30)

Country Link
EP (2) EP1484328B1 (en)
JP (1) JP2004527448A (en)
KR (1) KR20020038757A (en)
CN (1) CN1374959A (en)
AP (1) AP2002002459A0 (en)
AT (1) ATE284399T1 (en)
AU (1) AU7429500A (en)
BG (1) BG106524A (en)
BR (1) BR0014060A (en)
CA (1) CA2383836A1 (en)
CZ (1) CZ2002940A3 (en)
DE (2) DE60034713T2 (en)
DZ (1) DZ3195A1 (en)
EA (1) EA005183B1 (en)
EE (1) EE200200138A (en)
FR (1) FR2798656B1 (en)
GE (1) GEP20043223B (en)
HR (1) HRP20020214A2 (en)
HU (1) HUP0204283A3 (en)
IL (1) IL148720A0 (en)
MA (1) MA26820A1 (en)
MX (1) MXPA02001979A (en)
NO (1) NO20021253L (en)
OA (1) OA12022A (en)
PL (1) PL354809A1 (en)
SK (1) SK3632002A3 (en)
TN (1) TNSN00184A1 (en)
WO (1) WO2001025227A2 (en)
YU (1) YU19002A (en)
ZA (1) ZA200202073B (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
IL154107A0 (en) 2000-07-26 2003-07-31 Smithkline Beecham Plc Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US7109213B2 (en) 2002-01-29 2006-09-19 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
TW200406410A (en) 2002-01-29 2004-05-01 Glaxo Group Ltd Compounds
AR040336A1 (en) 2002-06-26 2005-03-30 Glaxo Group Ltd PIPERIDINE COMPOUND, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND PROCEDURE TO PREPARE SUCH COMPOUND
AR040335A1 (en) 2002-06-26 2005-03-30 Glaxo Group Ltd CYCLLOHEXAN OR CYCLHEXENE COMPOUND, USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, PROCEDURE AND INTERMEDIATE COMPOUNDS OF UTILITY TO PREPARE SUCH COMPOUND
FR2842807A1 (en) * 2002-07-23 2004-01-30 Aventis Pharma Sa QUINOLYL PROPYL PIPERIDINE DERIVATIVES, PROCESS AND PREPARATION INTERMEDIATES AND COMPOSITIONS COMPRISING THE SAME
FR2844268B1 (en) * 2002-09-11 2004-10-22 Aventis Pharma Sa QUINOLYL PROPYL PIPERIDINE DERIVATIVES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION, AND COMPOSITIONS CONTAINING THEM
FR2844270B1 (en) * 2002-09-11 2006-05-19 Aventis Pharma Sa QUINOLYL PROPYL PIPERIDINE DERIVATIVES, THEIR PROCESS AND PREPARATION INTERMEDIATES AND THE COMPOSITIONS CONTAINING THEM
AU2003301414B8 (en) * 2002-10-10 2010-06-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Novel compounds with antibacterial activity
ATE479683T1 (en) 2002-11-05 2010-09-15 Glaxo Group Ltd ANTIBACTERIAL AGENTS
US7232832B2 (en) 2002-11-05 2007-06-19 Smithkline Beecham Corporation Antibacterial agents
JP2006515862A (en) 2002-12-04 2006-06-08 グラクソ　グループ　リミテッド Quinolines and their nitrogenated derivatives and their use as antibacterial agents
EP1799674B1 (en) * 2004-10-05 2010-05-05 Actelion Pharmaceuticals Ltd. New piperidine antibiotics
ATE466857T1 (en) * 2004-10-05 2010-05-15 Actelion Pharmaceuticals Ltd NEW PIPERIDINE ANTIBIOTICS
US7592334B2 (en) 2005-01-25 2009-09-22 Glaxo Group Limited Antibacterial agents
EP1846416A4 (en) 2005-01-25 2009-07-01 Glaxo Group Ltd Antibacterial agents
EP1845995A4 (en) 2005-01-25 2010-03-03 Glaxo Group Ltd Antibacterial agents
WO2006081264A1 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
CA2635126A1 (en) 2006-01-26 2007-08-02 Actelion Pharmaceuticals Ltd Tetrahydropyrane antibiotics
US7709483B2 (en) 2006-04-06 2010-05-04 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
EP2481735A1 (en) * 2007-05-09 2012-08-01 Pfizer Inc. Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
JP5653935B2 (en) 2009-01-15 2015-01-14 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Naphthyridin-2 (1H) -one compounds useful as antibacterial agents
EP3057948B1 (en) * 2013-10-14 2018-03-14 Eisai R&D Management Co., Ltd. Selectively substituted quinoline derivatives
ES2759303T3 (en) 2014-08-22 2020-05-08 Glaxosmithkline Ip Dev Ltd Tricyclic nitrogen-containing compounds to treat Neisseria gonorrhoeae infection
UY36851A (en) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS
DK3889145T3 (en) 2015-12-17 2024-03-18 Merck Patent Gmbh 8-cyano-5-piperidino-quinolines as TLR7/8 antagonists and uses thereof for the treatment of immune diseases
DK3497094T3 (en) 2016-08-08 2023-05-15 Merck Patent Gmbh TLR7/8 ANTAGONISTS AND USES THEREOF

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037635A1 (en) * 1998-01-26 1999-07-29 Smithkline Beecham Plc Quinoline derivatives as antibacterials
AU2437900A (en) * 1999-01-20 2000-08-07 Smithkline Beecham Plc Piperidinylquinolines as protein tyrosine kinase inhibitors

Also Published As

Publication number Publication date
EP1484328B1 (en) 2007-05-02
WO2001025227A2 (en) 2001-04-12
DE60034713T2 (en) 2008-01-17
HUP0204283A3 (en) 2004-07-28
PL354809A1 (en) 2004-02-23
FR2798656A1 (en) 2001-03-23
EA200200374A1 (en) 2002-10-31
DE60016611D1 (en) 2005-01-13
NO20021253D0 (en) 2002-03-13
FR2798656B1 (en) 2004-12-17
EE200200138A (en) 2003-06-16
OA12022A (en) 2006-04-19
CA2383836A1 (en) 2001-04-12
SK3632002A3 (en) 2003-04-01
KR20020038757A (en) 2002-05-23
BG106524A (en) 2003-01-31
NO20021253L (en) 2002-04-24
IL148720A0 (en) 2002-09-12
DE60034713D1 (en) 2007-06-14
EP1218370B1 (en) 2004-12-08
JP2004527448A (en) 2004-09-09
AP2002002459A0 (en) 2002-06-30
CZ2002940A3 (en) 2002-07-17
DZ3195A1 (en) 2001-04-12
YU19002A (en) 2005-06-10
ZA200202073B (en) 2003-08-27
ATE284399T1 (en) 2004-12-15
BR0014060A (en) 2002-05-21
CN1374959A (en) 2002-10-16
DE60016611T2 (en) 2005-12-22
MXPA02001979A (en) 2002-08-20
MA26820A1 (en) 2004-12-20
EA005183B1 (en) 2004-12-30
EP1218370A2 (en) 2002-07-03
AU7429500A (en) 2001-05-10
TNSN00184A1 (en) 2005-11-10
WO2001025227A3 (en) 2001-11-22
EP1484328A1 (en) 2004-12-08
HRP20020214A2 (en) 2005-04-30
HUP0204283A2 (en) 2003-04-28

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