AU2001267687A1 - Ruthenium (ii) compounds for use in the therapy of cancer - Google Patents

Ruthenium (ii) compounds for use in the therapy of cancer

Info

Publication number
AU2001267687A1
AU2001267687A1 AU2001267687A AU6768701A AU2001267687A1 AU 2001267687 A1 AU2001267687 A1 AU 2001267687A1 AU 2001267687 A AU2001267687 A AU 2001267687A AU 6768701 A AU6768701 A AU 6768701A AU 2001267687 A1 AU2001267687 A1 AU 2001267687A1
Authority
AU
Australia
Prior art keywords
cancer
compounds
ruthenium
therapy
sup
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001267687A
Inventor
Haimei Chen
Duncan Jodrell
Robert Edward Morris Jr.
Peter John Sadler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Edinburgh
Original Assignee
University of Edinburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Edinburgh filed Critical University of Edinburgh
Publication of AU2001267687A1 publication Critical patent/AU2001267687A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0046—Ruthenium compounds

Abstract

Compounds which may be used in the treatment and/or prevention of cancer have the formula (I): wherein R<SUP>1 </SUP>and R<SUP>2 </SUP>together with the ring to which they are bound represent a saturated or unsaturated carbocyclic or heterocyclic group
AU2001267687A 2000-06-30 2001-06-26 Ruthenium (ii) compounds for use in the therapy of cancer Abandoned AU2001267687A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0016052 2000-06-30
GBGB0016052.3A GB0016052D0 (en) 2000-06-30 2000-06-30 Ruthenium (II) compounds
PCT/GB2001/002824 WO2002002572A1 (en) 2000-06-30 2001-06-26 Ruthenium (ii) compounds for use in the therapy of cancer

Publications (1)

Publication Number Publication Date
AU2001267687A1 true AU2001267687A1 (en) 2002-01-14

Family

ID=9894730

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001267687A Abandoned AU2001267687A1 (en) 2000-06-30 2001-06-26 Ruthenium (ii) compounds for use in the therapy of cancer

Country Status (14)

Country Link
US (1) US6936634B2 (en)
EP (1) EP1294732B1 (en)
JP (1) JP2004502696A (en)
AT (1) ATE273985T1 (en)
AU (1) AU2001267687A1 (en)
BR (1) BR0112122A (en)
CA (1) CA2414446A1 (en)
DE (1) DE60105028T2 (en)
DK (1) DK1294732T3 (en)
ES (1) ES2227225T3 (en)
GB (1) GB0016052D0 (en)
MX (1) MXPA02012911A (en)
PT (1) PT1294732E (en)
WO (1) WO2002002572A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1224192T3 (en) * 1999-10-27 2006-01-02 Univ Court The University Of E Half-sandwich ruthenium (II) compounds comprising nitrogen-containing ligands for the treatment of cancer
WO2003049760A1 (en) * 2001-12-07 2003-06-19 Intermune, Inc. Compositions and method for treating hepatitis virus infection
GB0215526D0 (en) * 2002-07-05 2002-08-14 Univ Edinburgh Anticancer compounds
DE602004014125D1 (en) * 2003-04-30 2008-07-10 Univ Edinburgh RUTHENIUM (II) COMPLEXES FOR THE TREATMENT OF TUMORS
GB0418643D0 (en) * 2004-08-20 2004-09-22 Univ Edinburgh Ruthenium (II) compounds
GB0604602D0 (en) * 2006-03-07 2006-04-19 Univ Edinburgh Ruthenium (II) compounds
GB0610062D0 (en) * 2006-05-19 2006-06-28 Univ Edinburgh Ruthenium (ll) compounds
CN101851256B (en) * 2010-04-30 2013-01-09 广东药学院 Ruthenium (II) porphyrin complex connected by flexible carbon chain and preparation method and application thereof
CN101863925B (en) * 2010-05-21 2012-08-29 广东药学院 Aryl ruthenium (11) composition and preparation method and application thereof
US9751081B2 (en) 2014-12-01 2017-09-05 Clemson University Self-regenerating antioxidant catalysts and methods of using the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980472A (en) * 1983-06-23 1990-12-25 American Cyanamid Company Method of making (3-amino-1H-pyrazol-4-yl) (aryl)methanones
WO1986000804A1 (en) 1984-07-24 1986-02-13 Byk Gulden Lomberg Chemische Fabrik Gesellschaft M Ruthenium compositions having a tumor inhibiting activity
WO1986000905A1 (en) * 1984-07-24 1986-02-13 Byk Gulden Lomberg Chemische Fabrik Gesellschaft M Ruthenium compounds having a tumor inhibiting activity
US4699978A (en) * 1985-01-18 1987-10-13 The Trustees Of Columbia University In The City Of New York Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents
US4980473A (en) * 1985-01-18 1990-12-25 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents
US5225556A (en) * 1985-01-18 1993-07-06 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and for A-DNA; chiral metal complexes as Z-specific antitumor agents and as double strand cleavers
AU4017695A (en) 1994-10-28 1996-05-23 Procept, Inc. Ruthenium complexes and their use as immunosuppressive agents
JPH11209314A (en) 1997-09-30 1999-08-03 Takasago Internatl Corp Production of cyclooctadienes
JP3488103B2 (en) * 1998-11-12 2004-01-19 高砂香料工業株式会社 Fragrance composition containing 4-methyl-5-hexene-1-al
GB0028025D0 (en) 2000-11-17 2001-01-03 Univ York Compounds

Also Published As

Publication number Publication date
GB0016052D0 (en) 2000-08-23
EP1294732B1 (en) 2004-08-18
WO2002002572A1 (en) 2002-01-10
MXPA02012911A (en) 2004-07-30
EP1294732A1 (en) 2003-03-26
US20040029852A1 (en) 2004-02-12
DE60105028D1 (en) 2004-09-23
BR0112122A (en) 2003-05-13
JP2004502696A (en) 2004-01-29
CA2414446A1 (en) 2002-01-10
PT1294732E (en) 2004-12-31
DE60105028T2 (en) 2005-08-18
ES2227225T3 (en) 2005-04-01
ATE273985T1 (en) 2004-09-15
US6936634B2 (en) 2005-08-30
DK1294732T3 (en) 2004-12-06

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