WO1998056759A3 - Neue pentaerythritderivate, deren herstellung und verwendung sowie intermediate zur synthese derselben - Google Patents

Neue pentaerythritderivate, deren herstellung und verwendung sowie intermediate zur synthese derselben Download PDF

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Publication number
WO1998056759A3
WO1998056759A3 PCT/DE1998/001635 DE9801635W WO9856759A3 WO 1998056759 A3 WO1998056759 A3 WO 1998056759A3 DE 9801635 W DE9801635 W DE 9801635W WO 9856759 A3 WO9856759 A3 WO 9856759A3
Authority
WO
WIPO (PCT)
Prior art keywords
pentaerythrite
novel
synthesis
derivatives
production
Prior art date
Application number
PCT/DE1998/001635
Other languages
English (en)
French (fr)
Other versions
WO1998056759A2 (de
Inventor
Gerd Koenig
Ulrich Hess
Anne-Katrin Windeck
Holger Brosig
Original Assignee
Isis Pharma Gmbh
Gerd Koenig
Ulrich Hess
Windeck Anne Katrin
Holger Brosig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU85321/98A priority Critical patent/AU8532198A/en
Priority to HU0002925A priority patent/HUP0002925A3/hu
Application filed by Isis Pharma Gmbh, Gerd Koenig, Ulrich Hess, Windeck Anne Katrin, Holger Brosig filed Critical Isis Pharma Gmbh
Priority to EP98936180A priority patent/EP0988282A2/de
Priority to JP50133099A priority patent/JP2002504903A/ja
Priority to SK1695-99A priority patent/SK169599A3/sk
Priority to US09/445,782 priority patent/US6365611B1/en
Priority to IL13341098A priority patent/IL133410A0/xx
Priority to DE19880813T priority patent/DE19880813D2/de
Priority to NZ501414A priority patent/NZ501414A/en
Priority to EA200000006A priority patent/EA200000006A1/ru
Priority to EEP199900568A priority patent/EE9900568A/xx
Priority to CA002293407A priority patent/CA2293407A1/en
Publication of WO1998056759A2 publication Critical patent/WO1998056759A2/de
Publication of WO1998056759A3 publication Critical patent/WO1998056759A3/de
Priority to NO996128A priority patent/NO996128L/no
Priority to BG104021A priority patent/BG104021A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

Die Erfindung beschreibt neue vom Pentaerythrit abgeleitete Verbindungen, wie sie in den Patentansprüchen definiert sind, beispielsweise Verbindungen der Formeln (XII) und (XVI), welche als pharmazeutische Wirkstoffe, insbesondere zur Behandlung von Herz-/Kreislauferkrankungen, Verwendung finden können.
PCT/DE1998/001635 1997-06-11 1998-06-11 Neue pentaerythritderivate, deren herstellung und verwendung sowie intermediate zur synthese derselben WO1998056759A2 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
NZ501414A NZ501414A (en) 1997-06-11 1998-06-11 Pentaerythritol derivatives, the production and uses thereof and intermediate products for the synthesis of active agents for treating heart/circulation and vascular illnesses
DE19880813T DE19880813D2 (de) 1997-06-11 1998-06-11 Neue Pentaerythritderivate, deren Herstellung und Verwendung sowie Intermediate zur Synthese derselben
EP98936180A EP0988282A2 (de) 1997-06-11 1998-06-11 Neue pentaerythritderivate, deren herstellung und verwendung sowie intermediate zur synthese derselben
HU0002925A HUP0002925A3 (en) 1997-06-11 1998-06-11 Novel pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same
SK1695-99A SK169599A3 (en) 1997-06-11 1998-06-11 Novel pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same
US09/445,782 US6365611B1 (en) 1997-06-11 1998-06-11 Pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same
EA200000006A EA200000006A1 (ru) 1997-06-11 1998-06-11 Новые производные пентаэритрита, их получение и применение, а также промежуточные соединения для их синтеза
AU85321/98A AU8532198A (en) 1997-06-11 1998-06-11 Novel pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same
JP50133099A JP2002504903A (ja) 1997-06-11 1998-06-11 ペンタエリスリトール新規誘導体、その製造及び使用、並びにその合成の為の中間体
IL13341098A IL133410A0 (en) 1997-06-11 1998-06-11 Novel pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same
EEP199900568A EE9900568A (et) 1997-06-11 1998-06-11 Pentaerütriidi uued derivaadid, nende valmistamine, kasutamine ja vaheühendid nende sünteesiks
CA002293407A CA2293407A1 (en) 1997-06-11 1998-06-11 Novel pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same
NO996128A NO996128L (no) 1997-06-11 1999-12-10 Nye pentaerytrittderivater, deres fremstilling og anvendelse så vel som mellomprodukter for deres syntese
BG104021A BG104021A (bg) 1997-06-11 1999-12-16 Нови производни на пентаеритрит, получаването и използването им, както и междинни съединения за тяхната синтеза

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19725340 1997-06-11
DE19725340.7 1997-06-11

Publications (2)

Publication Number Publication Date
WO1998056759A2 WO1998056759A2 (de) 1998-12-17
WO1998056759A3 true WO1998056759A3 (de) 1999-09-16

Family

ID=7832585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1998/001635 WO1998056759A2 (de) 1997-06-11 1998-06-11 Neue pentaerythritderivate, deren herstellung und verwendung sowie intermediate zur synthese derselben

Country Status (20)

Country Link
US (1) US6365611B1 (de)
EP (1) EP0988282A2 (de)
JP (1) JP2002504903A (de)
CN (1) CN1266429A (de)
AU (1) AU8532198A (de)
BG (1) BG104021A (de)
CA (1) CA2293407A1 (de)
DE (2) DE19826781A1 (de)
EA (1) EA200000006A1 (de)
EE (1) EE9900568A (de)
HR (1) HRP980313A2 (de)
HU (1) HUP0002925A3 (de)
IL (1) IL133410A0 (de)
NO (1) NO996128L (de)
NZ (1) NZ501414A (de)
PL (1) PL337775A1 (de)
SK (1) SK169599A3 (de)
TR (2) TR200003352T2 (de)
WO (1) WO1998056759A2 (de)
ZA (1) ZA985064B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1306184B1 (it) * 1999-08-05 2001-05-30 Sigma Tau Ind Farmaceuti Nitrilossi derivati della (r) e (s)-carnitina.
DE19950483A1 (de) * 1999-10-19 2001-05-10 Isis Pharma Gmbh Verfahren zur Herstellung von 3-Nitryloxy-2,2-bis(nitryloxymethyl)-propanal
US20040009944A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Methylated immunostimulatory oligonucleotides and methods of using the same
US20040013649A1 (en) * 2002-05-10 2004-01-22 Inex Pharmaceuticals Corporation Cancer vaccines and methods of using the same
WO2005034979A2 (en) * 2003-10-11 2005-04-21 Inex Pharmaceuticals Corporation Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6487M (de) * 1966-04-06 1968-11-25
EP0367019A1 (de) * 1988-10-22 1990-05-09 Roche Diagnostics GmbH Arzneimittel enthaltend Nitroxyalkylamine mit Amidfunktion und Verfahren zur Herstellung dieser Verbindungen
DE19515970A1 (de) * 1995-05-02 1996-11-07 Bayer Ag Acetylsalicylsäurenitrate
WO1998015521A1 (de) * 1996-10-10 1998-04-16 Isis Pharma Gmbh Neue derivate des pentaerythrits, deren herstellung und verwendung sowie intermediate zur synthese derselben

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6487M (de) * 1966-04-06 1968-11-25
EP0367019A1 (de) * 1988-10-22 1990-05-09 Roche Diagnostics GmbH Arzneimittel enthaltend Nitroxyalkylamine mit Amidfunktion und Verfahren zur Herstellung dieser Verbindungen
DE19515970A1 (de) * 1995-05-02 1996-11-07 Bayer Ag Acetylsalicylsäurenitrate
WO1998015521A1 (de) * 1996-10-10 1998-04-16 Isis Pharma Gmbh Neue derivate des pentaerythrits, deren herstellung und verwendung sowie intermediate zur synthese derselben

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HEWLINS, STUART A. ET AL: "Nitration of.alpha.,.beta.-unsaturated esters. evidence for positive charge build-up adjacent to carbonyl carbon", J. CHEM. SOC., PERKIN TRANS. 1 (1997), (10), 1559-1570, 21 May 1997 (1997-05-21), XP002107879 *

Also Published As

Publication number Publication date
NZ501414A (en) 2001-12-21
EE9900568A (et) 2000-08-15
AU8532198A (en) 1998-12-30
CN1266429A (zh) 2000-09-13
NO996128D0 (no) 1999-12-10
SK169599A3 (en) 2000-11-07
CA2293407A1 (en) 1998-12-17
DE19826781A1 (de) 1998-12-17
PL337775A1 (en) 2000-09-11
WO1998056759A2 (de) 1998-12-17
HUP0002925A3 (en) 2002-11-28
HRP980313A2 (en) 1999-04-30
US6365611B1 (en) 2002-04-02
TR199903054T2 (xx) 2000-07-21
TR200003352T2 (tr) 2001-02-21
EP0988282A2 (de) 2000-03-29
JP2002504903A (ja) 2002-02-12
EA200000006A1 (ru) 2000-08-28
IL133410A0 (en) 2001-04-30
HUP0002925A2 (hu) 2001-07-30
ZA985064B (en) 1998-08-28
DE19880813D2 (de) 2000-05-31
BG104021A (bg) 2000-07-31
NO996128L (no) 1999-12-10

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