IT1399764B1 - Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam. - Google Patents
Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam.Info
- Publication number
- IT1399764B1 IT1399764B1 ITMI2010A000777A ITMI20100777A IT1399764B1 IT 1399764 B1 IT1399764 B1 IT 1399764B1 IT MI2010A000777 A ITMI2010A000777 A IT MI2010A000777A IT MI20100777 A ITMI20100777 A IT MI20100777A IT 1399764 B1 IT1399764 B1 IT 1399764B1
- Authority
- IT
- Italy
- Prior art keywords
- midazolam
- benzodiazepine
- imidazo
- synthesis
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2010A000777A IT1399764B1 (it) | 2010-05-04 | 2010-05-04 | Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam. |
EP11162957A EP2397470B1 (en) | 2010-05-04 | 2011-04-19 | Process for the synthesis of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular midazolam and salts thereof |
IL212505A IL212505A (en) | 2010-05-04 | 2011-04-26 | Process for Synthesis of 4h - Imidazo [5,1– a] [4,1] Benzodiazepines, especially Midazolam and its salts |
US13/099,820 US8557981B2 (en) | 2010-05-04 | 2011-05-03 | Process for the synthesis of 4H-imidazo [1,5-a] [1,4] benzodiazepines, in particular midazolam and salts thereof |
CN201110119221.7A CN102241679B (zh) | 2010-05-04 | 2011-05-04 | 合成4H-咪唑并[1,5-a][1,4]苯二氮*特别是咪达唑仑和其盐的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2010A000777A IT1399764B1 (it) | 2010-05-04 | 2010-05-04 | Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam. |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI20100777A1 ITMI20100777A1 (it) | 2011-11-05 |
IT1399764B1 true IT1399764B1 (it) | 2013-05-03 |
Family
ID=43216970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI2010A000777A IT1399764B1 (it) | 2010-05-04 | 2010-05-04 | Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam. |
Country Status (5)
Country | Link |
---|---|
US (1) | US8557981B2 (it) |
EP (1) | EP2397470B1 (it) |
CN (1) | CN102241679B (it) |
IL (1) | IL212505A (it) |
IT (1) | IT1399764B1 (it) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103319486B (zh) * | 2012-03-22 | 2017-10-10 | 徐州市心血管病研究所 | 合成4H‑咪唑并[1,5‑a][1,4]苯二氮卓,特别是咪达唑仑的方法 |
AU2017313753B2 (en) | 2016-08-16 | 2022-01-27 | The Trustees Of Columbia University In The City Of New York | GABA(A) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma |
CN108033964B (zh) * | 2017-12-28 | 2021-02-09 | 杭州奥默医药股份有限公司 | 一种吡啶基咪唑并苯并二氮杂卓丙酸酯化合物及其合成和应用 |
CN111320632B (zh) * | 2018-12-14 | 2021-06-01 | 江苏恩华药业股份有限公司 | 盐酸咪达唑仑的新晶型及其制备方法 |
CN111410658B (zh) * | 2020-03-30 | 2021-03-26 | 江苏恩华药业股份有限公司 | 咪达唑仑或其药物组合物的杂质a和杂质b及其用途 |
CN113149992B (zh) * | 2021-01-15 | 2023-05-16 | 福安药业集团重庆礼邦药物开发有限公司 | 一种盐酸咪达唑仑f晶型的制备方法及用途 |
CN113149914A (zh) * | 2021-01-15 | 2021-07-23 | 福安药业集团重庆礼邦药物开发有限公司 | 一种咪达唑仑中间体脱氟杂质的制备方法 |
CN115232132B (zh) * | 2022-07-25 | 2024-02-13 | 福安药业集团重庆礼邦药物开发有限公司 | 一种盐酸咪达唑仑g晶型及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4280957A (en) * | 1974-09-11 | 1981-07-28 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
ZA755418B (en) * | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
CA2184802C (en) * | 1995-10-10 | 2007-07-31 | Karl-Heinz Bender | Process for manufacture of imidazo benzodiazepine derivatives |
US6512114B1 (en) * | 1999-06-30 | 2003-01-28 | Abbott Laboratories | Process for the preparation of Midazolam |
US20010014738A1 (en) * | 1999-06-30 | 2001-08-16 | Madhup K. Dhaon | Process for the preparation of imidazodiazepine intermediates |
US6262260B1 (en) * | 2000-03-23 | 2001-07-17 | Abbott Laboratories | Process for the preparation of midazolam |
US7776852B2 (en) * | 2007-09-11 | 2010-08-17 | Chemagis Ltd. | Process for producing highly pure midazolam and salts thereof |
-
2010
- 2010-05-04 IT ITMI2010A000777A patent/IT1399764B1/it active
-
2011
- 2011-04-19 EP EP11162957A patent/EP2397470B1/en active Active
- 2011-04-26 IL IL212505A patent/IL212505A/en active IP Right Grant
- 2011-05-03 US US13/099,820 patent/US8557981B2/en not_active Expired - Fee Related
- 2011-05-04 CN CN201110119221.7A patent/CN102241679B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
IL212505A0 (en) | 2011-07-31 |
CN102241679B (zh) | 2014-08-13 |
EP2397470A1 (en) | 2011-12-21 |
CN102241679A (zh) | 2011-11-16 |
ITMI20100777A1 (it) | 2011-11-05 |
EP2397470B1 (en) | 2013-01-16 |
US20110275799A1 (en) | 2011-11-10 |
US8557981B2 (en) | 2013-10-15 |
IL212505A (en) | 2013-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL257410A (en) | Pyrazolo [1, 5 – a ] pyrimidines as antiviral agents | |
FR21C1011I2 (fr) | 5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-carboxamides utilises en tant qu'inhibiteurs de jak | |
HK1257363A1 (zh) | 用於在聚合酶的抑制中使用的吡咯並嘧啶衍生物 | |
CO6801740A2 (es) | Inhibidores de quinasa relacionados con pirrolo[2,3-d]pirimidina tropomiosina | |
EP2608669A4 (en) | NEW PYRAZOLO- [1,5-A-] PYRIMIDINE DERIVATIVES AS ANTI-MTOR HEMMER | |
IT1399764B1 (it) | Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam. | |
ZA201307839B (en) | Pyrazolo[4,3-d] pyrimidines useful as kinase inhibitors | |
HK1204619A1 (en) | Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrim as lrrk2 inhibitors lrrk2 4-()-7h-[23-d] | |
PT2794611T (pt) | Pirazolo[1,5-a]pirimidinas como agentes antivirais | |
IL227963A0 (en) | History History of cytotoxic benzodiazepines, preparations containing them and their uses | |
DK3486245T3 (da) | 2-amino-n-(piperidin-1-yl-pyridin-3-yl) pyrazolo[1,5alpha]pyrimidin-3-carboxamid som hæmmer for atr kinase | |
DK2384326T3 (da) | Pyrrolo[2,3-d]pyrimidinforbindelser | |
IL229606A0 (en) | Pyrazolone [3, 4-d] pyrimidine compounds and their use as 2pde inhibitors and/or 4a3 cyp inhibitors | |
HK1158947A1 (en) | Macrocyclic pyrimidines as protein kinase inhibitors | |
BRPI1012108A2 (pt) | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octano- ou heptano-nitrila como inibidores de jak | |
EP2525659A4 (en) | PYRAZOLO [1,5-A] PYRIMIDINES COMPOUNDS AS MTOR INHIBITORS | |
BRPI1008850A2 (pt) | [1,2,4]triazolo[1,5-a]piridinas como inibidores de quinase | |
ZA201403441B (en) | [1,2,3]triazolo[4,5-d]pyrimidine derivatives as agonists of the cannabinoid | |
IL229993A (en) | 8 - Alkoxy [1,2,4] triazolo [5,1 – c] pyrimidine– 2 | |
ZA201406323B (en) | Triazolo[4,5-d]pyrimidine derivatives | |
EP2523552A4 (en) | PYRAZOLO- [1,5-A] PYRIMIDINE AS MARK HEMMER | |
CL2013003492A1 (es) | Procedimiento de preparacion de 6-[7-hidroxi-6,7-dihidro-5h-pirrolo[1,2-c]imidazol-7-il]-n-metil-2-naftamida. | |
BR112013012547A2 (pt) | antifúngicos 5,6-di-hidro-4h-pirrolo][1,4]benzodiazepinas e 6h-pirrolo [1,2-a] [1,4]benzodiazepinas substituídos por derivados de fenila | |
ITMI20111766A1 (it) | Manufatto per la preparazione di articoli imbottiti. |