BR0111377A - Derivados de tiofeno úteis como agentes anticancerìgenos - Google Patents

Derivados de tiofeno úteis como agentes anticancerìgenos

Info

Publication number
BR0111377A
BR0111377A BR0111377-1A BR0111377A BR0111377A BR 0111377 A BR0111377 A BR 0111377A BR 0111377 A BR0111377 A BR 0111377A BR 0111377 A BR0111377 A BR 0111377A
Authority
BR
Brazil
Prior art keywords
thiophene derivatives
anticancer agents
derivatives useful
formula
compounds
Prior art date
Application number
BR0111377-1A
Other languages
English (en)
Inventor
Michael Joseph Luzzio
Natthew Arnold Marx
Bingwei Vera Yang
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0111377A publication Critical patent/BR0111377A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"DERIVADOS DE TIOFENO úTEIS COMO AGENTES ANTICANCERìGENOS". A invenção refere-se a compostos da fórmula (1) ou um sal farmaceuticamente aceitável e a outros sais e hidratos derivados farmaceuticamente aceitáveis, em que X, Y, R^ 1^, R^ 2^ e R^ 3^ são como aqui definidos. A invenção também refere-se a composições farmacêuticas contendo os compostos de fórmula (1) e a métodos para o tratamento de distúrbios hiperproliferativos em um mamífero por administração de compostos de fórmula (1).
BR0111377-1A 2000-06-06 2001-05-02 Derivados de tiofeno úteis como agentes anticancerìgenos BR0111377A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20968600P 2000-06-06 2000-06-06
PCT/IB2001/000766 WO2001094353A1 (en) 2000-06-06 2001-05-02 Thiophene derivatives useful as anticancer agents

Publications (1)

Publication Number Publication Date
BR0111377A true BR0111377A (pt) 2003-06-03

Family

ID=22779830

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0111377-1A BR0111377A (pt) 2000-06-06 2001-05-02 Derivados de tiofeno úteis como agentes anticancerìgenos

Country Status (22)

Country Link
US (1) US6964961B2 (pt)
EP (1) EP1287001B1 (pt)
JP (1) JP2003535867A (pt)
AR (1) AR032621A1 (pt)
AT (1) ATE277933T1 (pt)
AU (1) AU2001252463A1 (pt)
BR (1) BR0111377A (pt)
CA (1) CA2411084A1 (pt)
DE (1) DE60106022T2 (pt)
DO (1) DOP2001000170A (pt)
EC (1) ECSP014097A (pt)
ES (1) ES2223827T3 (pt)
GT (1) GT200100104A (pt)
MX (1) MXPA02012034A (pt)
PA (1) PA8518701A1 (pt)
PE (1) PE20011373A1 (pt)
PT (1) PT1287001E (pt)
SV (1) SV2002000478A (pt)
TN (1) TNSN01082A1 (pt)
TR (1) TR200402656T4 (pt)
UY (1) UY26750A1 (pt)
WO (1) WO2001094353A1 (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4609691B2 (ja) * 1999-07-01 2011-01-12 味の素株式会社 複素環化合物及びその医薬用途
MXPA03000874A (es) * 2000-08-09 2003-06-06 Astrazeneca Ab Compuestos quimicos.
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
US7101898B2 (en) 2002-02-01 2006-09-05 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
RU2366652C2 (ru) * 2002-02-01 2009-09-10 ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Амиды аминоалкилзамещенных азетидинов, пирролидинов, пиперидинов и азепанов
EP1483268A2 (en) * 2002-03-01 2004-12-08 Pfizer Inc. Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents
BR0311605A (pt) * 2002-06-06 2005-02-22 Boehringer Ingelheim Pharma Compostos de amida de ácido 3-aminotieno[2,3-b]piridina-2-carboxìlico substituìdo e processos para preparação e seus usos
UA77303C2 (en) * 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
US7488823B2 (en) 2003-11-10 2009-02-10 Array Biopharma, Inc. Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
CL2003002287A1 (es) * 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
US7276519B2 (en) * 2002-11-25 2007-10-02 Wyeth Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
SI1611131T1 (sl) 2003-02-27 2011-03-31 Palau Pharma Sa Pirazolopiridinski derivati
US7592352B2 (en) * 2003-05-06 2009-09-22 Smithkline Beecham Corporation Substituted thieno and furo-pyridines
PT1660090E (pt) 2003-08-14 2013-01-11 Array Biopharma Inc Análogos de quinazolina como inibidores de tirosina-cinases recetoras
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US20050288290A1 (en) 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
AU2005266803B2 (en) 2004-07-30 2011-10-27 Methylgene Inc. Inhibitors of VEGF receptor and HGF receptor signaling
AU2006313456B2 (en) 2005-05-20 2011-06-23 Methylgene Inc. Inhibitors of VEGF receptor and HGF receptor signaling
KR101378716B1 (ko) 2005-05-20 2014-04-10 메틸진 인코포레이티드 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제
US7880004B2 (en) 2005-09-15 2011-02-01 Bristol-Myers Squibb Company Met kinase inhibitors
AR056200A1 (es) * 2005-09-27 2007-09-26 Wyeth Corp Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
US8648087B2 (en) 2005-11-15 2014-02-11 Array Biopharma, Inc. N4-phenyl-quinazoline-4-amine derivatives and related compounds as ErbB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases
AR059246A1 (es) * 2006-01-30 2008-03-19 Array Biopharma Inc Compuestos heterobiciclicos de tiofeno y metodos de uso
JP5516397B2 (ja) 2007-04-05 2014-06-11 アムジエン・インコーポレーテツド オーロラキナーゼ調節物質及び使用方法
RU2533827C2 (ru) 2008-03-05 2014-11-20 Метилджин Инк. Ингибиторы активности протеинтирозинкиназы
US8404694B2 (en) 2008-03-20 2013-03-26 Amgen Inc. Aurora kinase modulators and method of use
WO2010019473A1 (en) 2008-08-14 2010-02-18 Amgen Inc. Aurora kinase modulators and methods of use
DK2355822T3 (da) 2008-11-19 2013-01-28 Envivo Pharmaceuticals Inc behandling af kognitive forstyrrelser med (R)-7-chlor-N-(quinuclidin-3-yl)benzoe[b]thiophen-2-carboxamid og farmaceutisk acceptable salte deraf
JP5808319B2 (ja) * 2009-05-11 2015-11-10 フォルム ファーマシューティカルズ、インコーポレイテッド アセチルコリンエステラーゼ阻害剤と組み合わせた特定のα７ニコチン酸受容体を用いた認知障害の治療
RU2577334C2 (ru) 2010-05-17 2016-03-20 Энвиво Фармасьютикалз, Инк. КРИСТАЛЛИЧЕСКАЯ ФОРМА МОНОГИДРАТА ГИДРОХЛОРИДА (R)-7-ХЛОР-N-(ХИНУКЛИДИН-3-ИЛ)БЕНЗО[b]ТИОФЕН-2-КАРБОКСАМИДА
AU2013259871A1 (en) 2012-05-08 2014-11-20 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function
FR3080620B1 (fr) * 2018-04-27 2021-11-12 Univ Paris Sud Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
CN113648307B (zh) * 2021-09-23 2022-09-30 河南大学 MII-tt-DTT及其在制备抗结直肠癌药物中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071227B1 (en) 1981-07-31 1987-11-11 Sloan-Kettering Institute For Cancer Research Anti-leukemic beta-glycosyl c-nucleosides
US5124331A (en) 1988-03-02 1992-06-23 Yoshitomi Pharmaceutical Industries, Ltd. 3,4-dihydrothieno[2,3-d]pyrimidine compounds and their pharmaceutical use
JPH02256667A (ja) * 1988-12-27 1990-10-17 Masatoshi Yamato 縮合キノリン系化合物およびその製造方法
CA2039411A1 (en) 1990-03-30 1991-10-01 Ronnie Gerald Edie Thienopyrimidine derivatives
US5187168A (en) * 1991-10-24 1993-02-16 American Home Products Corporation Substituted quinazolines as angiotensin II antagonists
WO1993017021A1 (en) 1992-02-19 1993-09-02 Pfizer, Inc. Heterocyclic compounds for enhancing antitumor activity
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US5679683A (en) * 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
WO1996040142A1 (en) 1995-06-07 1996-12-19 Pfizer Inc. Heterocyclic ring-fused pyrimidine derivatives
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
DK0778277T3 (da) 1995-12-08 2003-10-27 Pfizer Substituerede heterocycliske derivater som CRF antagonister
DK0882051T3 (da) 1996-02-07 2002-02-25 Janssen Pharmaceutica Nv Thiophenopyrimidiner
JP2000505109A (ja) 1996-11-27 2000-04-25 ファイザー・インク 縮合二環式ピリミジン誘導体
ZA986729B (en) * 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
CN101328186A (zh) * 1997-11-11 2008-12-24 辉瑞产品公司 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物

Also Published As

Publication number Publication date
DE60106022D1 (de) 2004-11-04
MXPA02012034A (es) 2003-04-25
PE20011373A1 (es) 2002-01-18
UY26750A1 (es) 2002-01-31
WO2001094353A1 (en) 2001-12-13
GT200100104A (es) 2002-01-31
ES2223827T3 (es) 2005-03-01
JP2003535867A (ja) 2003-12-02
SV2002000478A (es) 2002-07-03
TNSN01082A1 (fr) 2005-11-10
DOP2001000170A (es) 2002-05-15
US6964961B2 (en) 2005-11-15
PA8518701A1 (es) 2002-09-17
ATE277933T1 (de) 2004-10-15
US20020042409A1 (en) 2002-04-11
AR032621A1 (es) 2003-11-19
DE60106022T2 (de) 2006-03-09
EP1287001B1 (en) 2004-09-29
PT1287001E (pt) 2004-12-31
ECSP014097A (es) 2003-02-06
EP1287001A1 (en) 2003-03-05
TR200402656T4 (tr) 2004-11-22
CA2411084A1 (en) 2001-12-13
AU2001252463A1 (en) 2001-12-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A, 9A E 10A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011.