PE20011373A1 - Derivados de tiofeno de formula (i) - Google Patents

Derivados de tiofeno de formula (i)

Info

Publication number
PE20011373A1
PE20011373A1 PE2001000510A PE2001000510A PE20011373A1 PE 20011373 A1 PE20011373 A1 PE 20011373A1 PE 2001000510 A PE2001000510 A PE 2001000510A PE 2001000510 A PE2001000510 A PE 2001000510A PE 20011373 A1 PE20011373 A1 PE 20011373A1
Authority
PE
Peru
Prior art keywords
alkyl
methyl
indol
pyridin
thiophene derivatives
Prior art date
Application number
PE2001000510A
Other languages
English (en)
Inventor
Marx Matthew Arnold Arnold
Bingwei Vera Yang
Michael Joseph Luzzio
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20011373A1 publication Critical patent/PE20011373A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE REFIERE A DERIVADOS DE TIOFENO DE FORMULA I DONDE X ES N, CH, C(CN); Y ES N, CH, CF, N-O; R1 ES H, ALQUILO C1-C6; R2 ES HETEROCICLO DE 5 A 13 MIEMBROS, GRUPO R2 CON 1 A 5 SUSTITUYENTES R5; R5 ES HALO, CIANO, TRIFLUOROMETOXILO, TRIFLUOROMETILO, -C(O)R8, -NR6-C(O)R7, -C(O)NR6R7, -NR6R7, ENTRE OTROS; R6 Y R7 SON H, ALQUILO C1-C6, -(CH2)t(ARILO C6-C10), -(CH2)t(HETEROCICLO DE 5 A 10 MIEMBROS), -(CH2)tO(CH2)qOR9, ENTRE OTROS; R8 ES H, ALQUILO C1-C10, -(CH2)t(ARILO C6-C10), (CH2)t(HETEROCICLO DE 5 A 10 MIEMBROS; t ES 0-6; q ES 2-6; R9 Y R10 SON H, ALQUILO C1-C6; R11 ES -C(O)NR12R13, -(CH2)tNR12R13, -NR12C(=O)R13, -SO2-R12, ENTRE OTROS; R12 Y R13 SON H, ALQUILO C1-C6, ENTRE OTROS; R12 Y R13 JUNTO A N FORMAN UN ANILLO AZABICICLICO C5-C9, AZIRIDINILO, AZETIDINILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS METIL-PIRIDIN-3-ILMETIL-AMIDA DEL ACIDO 7-(2-METIL-1H-INDOL-5-ILAMINO)-TIENO[3,2-b]PIRIDINA-2-CARBOXILICO, AZETIDIN-1-IL-{7-(2-METIL-1H-INDOL-5-ILAMINO)-TIENO-[3,2-b]PIRIDIN-2-IL}-METANONA, {7-(2-METIL-1H-INDOL-5-ILAMINO)-TIENO-[3,2-b]PIRIDIN-2-IL}-PIRROLIDIN-1-IL-METANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DERIVADOS DE TIOFENO Y SON UTILES PARA EL TRATAMIENTO DE UN TRASTORNO HIPERPROLIFERATIVO, COMO CANCER
PE2001000510A 2000-06-06 2001-06-01 Derivados de tiofeno de formula (i) PE20011373A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20968600P 2000-06-06 2000-06-06

Publications (1)

Publication Number Publication Date
PE20011373A1 true PE20011373A1 (es) 2002-01-18

Family

ID=22779830

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000510A PE20011373A1 (es) 2000-06-06 2001-06-01 Derivados de tiofeno de formula (i)

Country Status (22)

Country Link
US (1) US6964961B2 (es)
EP (1) EP1287001B1 (es)
JP (1) JP2003535867A (es)
AR (1) AR032621A1 (es)
AT (1) ATE277933T1 (es)
AU (1) AU2001252463A1 (es)
BR (1) BR0111377A (es)
CA (1) CA2411084A1 (es)
DE (1) DE60106022T2 (es)
DO (1) DOP2001000170A (es)
EC (1) ECSP014097A (es)
ES (1) ES2223827T3 (es)
GT (1) GT200100104A (es)
MX (1) MXPA02012034A (es)
PA (1) PA8518701A1 (es)
PE (1) PE20011373A1 (es)
PT (1) PT1287001E (es)
SV (1) SV2002000478A (es)
TN (1) TNSN01082A1 (es)
TR (1) TR200402656T4 (es)
UY (1) UY26750A1 (es)
WO (1) WO2001094353A1 (es)

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DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
US7101898B2 (en) 2002-02-01 2006-09-05 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
CA2473468C (en) * 2002-02-01 2011-06-21 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
MXPA04008403A (es) 2002-03-01 2004-11-26 Pfizer Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su uso.
WO2003103661A1 (en) * 2002-06-06 2003-12-18 Boehringer Ingelheim Pharmaceuticals, Inc. SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES
UA77303C2 (en) * 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
US7488823B2 (en) 2003-11-10 2009-02-10 Array Biopharma, Inc. Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
CL2003002287A1 (es) * 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
US7276519B2 (en) 2002-11-25 2007-10-02 Wyeth Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
AU2004215644B2 (en) 2003-02-27 2010-09-02 Palau Pharma, S.A. Pyrazolopyridine derivates
US7592352B2 (en) * 2003-05-06 2009-09-22 Smithkline Beecham Corporation Substituted thieno and furo-pyridines
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
DK1660090T3 (da) 2003-08-14 2012-12-17 Array Biopharma Inc Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US20050288290A1 (en) 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
KR101257343B1 (ko) 2004-07-30 2013-04-23 메틸진 인코포레이티드 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달 억제제
BRPI0610322B8 (pt) 2005-05-20 2021-05-25 Methylgene Inc inibidores de sinalização de receptor de vegf e de receptor de hgf e composição farmacêutica
ES2473341T3 (es) 2005-05-20 2014-07-04 Methylgene Inc Inhibidores de la se�alizaci�n del receptor del VEGF y del receptor del HGF
WO2007035428A1 (en) 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
AR056200A1 (es) * 2005-09-27 2007-09-26 Wyeth Corp Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
EP1971601B1 (en) 2005-11-15 2009-10-21 Array Biopharma Inc. N4-phenyl-quinazoline-4 -amine derivatives and related compounds as erbb type i receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases
CA2636242A1 (en) * 2006-01-30 2008-05-29 Array Biopharma, Inc. Heterobicyclic thiophene compounds and methods of use
WO2008124083A2 (en) 2007-04-05 2008-10-16 Amgen Inc. Aurora kinase modulators and method of use
BRPI0923670A2 (pt) 2008-03-05 2013-07-30 Methylgene Inc inibidores da atividade de proteÍna tirosina quinase e seu uso, bem como composiÇço compreendendo os mesmos
WO2009117157A1 (en) 2008-03-20 2009-09-24 Amgen Inc. Aurora kinase modulators and method of use
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Also Published As

Publication number Publication date
AR032621A1 (es) 2003-11-19
EP1287001A1 (en) 2003-03-05
MXPA02012034A (es) 2003-04-25
WO2001094353A1 (en) 2001-12-13
ATE277933T1 (de) 2004-10-15
DOP2001000170A (es) 2002-05-15
US20020042409A1 (en) 2002-04-11
PA8518701A1 (es) 2002-09-17
UY26750A1 (es) 2002-01-31
CA2411084A1 (en) 2001-12-13
DE60106022D1 (de) 2004-11-04
TR200402656T4 (tr) 2004-11-22
DE60106022T2 (de) 2006-03-09
TNSN01082A1 (fr) 2005-11-10
ECSP014097A (es) 2003-02-06
JP2003535867A (ja) 2003-12-02
GT200100104A (es) 2002-01-31
EP1287001B1 (en) 2004-09-29
BR0111377A (pt) 2003-06-03
PT1287001E (pt) 2004-12-31
ES2223827T3 (es) 2005-03-01
AU2001252463A1 (en) 2001-12-17
SV2002000478A (es) 2002-07-03
US6964961B2 (en) 2005-11-15

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