AR043487A1 - Heterociclos fusionados de pirimidina y usos de los mismos - Google Patents

Heterociclos fusionados de pirimidina y usos de los mismos

Info

Publication number
AR043487A1
AR043487A1 ARP040100701A ARP040100701A AR043487A1 AR 043487 A1 AR043487 A1 AR 043487A1 AR P040100701 A ARP040100701 A AR P040100701A AR P040100701 A ARP040100701 A AR P040100701A AR 043487 A1 AR043487 A1 AR 043487A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
independently selected
alkyl
alkynyl
alkenyl
Prior art date
Application number
ARP040100701A
Other languages
English (en)
Inventor
Brian Aquila
Michael Block
Audrey Davies
Timothy Pontz
Marie Theoclitou
Ziaolan Zheng
Sandra Filla
Richard Luke
Jayachandran Ezhuthachan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0300627A external-priority patent/SE0300627D0/xx
Priority claimed from SE0301138A external-priority patent/SE0301138D0/xx
Priority claimed from SE0301697A external-priority patent/SE0301697D0/xx
Priority claimed from SE0302826A external-priority patent/SE0302826D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR043487A1 publication Critical patent/AR043487A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos, composiciones farmacéuticas que los contienen y métodos de uso de los mismos. Estos nuevos compuestos proveen un tratamiento o profilaxis del cáncer. Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula estructural (1) donde: A es C=O, CH2, o SO2; B representa alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, arilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, o heterociclo opcionalmente sustituido; D es O o N donde O es opcionalmente sustituido con un R8, donde N es opcionalmente sustituido con uno o más R8, y cuando n es 0 y m es 0, R8 se adjunta directamente a B; R1 y R2 en combinación forman un anillo heteroaromático fusionado de 5 miembros está opcionalmente sustituido con 1 o 2 sustituyentes, dicho anillo tiene al menos un átomo de N, O o S, pero no más de 2 átomos de O o 2 átomos de S o 1 átomo de O y un átomo de S; R3 se selecciona independientemente entre H, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, cicloalquenilo opcionalmente sustituido, cicloalquinilo opcionalmente sustituido, arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido; R4 y R5 se seleccionan independientemente entre H o alquilo opcionalmente sustituido, o R4 y R5 en combinación forman un anillo de 3, 4, 5 o 6 miembros, el cual puede también ser opcionalmente sustituido; R6 y R7 se seleccionan independientemente entre H, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, cicloalquenilo opcionalmente sustituido, cicloalquinilo opcionalmente sustituido, heterociclo opcionalmente sustituido, arilo opcionalmente sustituido, o R6 y R7 en combinación forman un anillo de 3,4, 5 o 6 miembros, el cual también puede ser sustituido; R8 se selecciona independientemente entre H, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, cicloalquenilo opcionalmente sustituido, cicloalquinilo opcionalmente sustituido, arilo opcionalmente sustituido, o heterociclo opcionalmente sustituido; R9 se selecciona independientemente entre H, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, cicloalquenilo opcionalmente sustituido, cicloalquinilo opcionalmente sustituido, arilo opcionalmente sustituido, o heterociclo opcionalmente sustituido.
ARP040100701A 2003-03-07 2004-03-05 Heterociclos fusionados de pirimidina y usos de los mismos AR043487A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0300627A SE0300627D0 (sv) 2003-03-07 2003-03-07 Novel fused heterocycles and uses therof
SE0301138A SE0301138D0 (sv) 2003-04-15 2003-04-15 Novel fused heterocycles and uses thereof
SE0301697A SE0301697D0 (sv) 2003-06-10 2003-06-10 Novel fused heterocycles and uses thereof
SE0302826A SE0302826D0 (sv) 2003-10-24 2003-10-24 Novel fused heterocycles and uses thereof

Publications (1)

Publication Number Publication Date
AR043487A1 true AR043487A1 (es) 2005-08-03

Family

ID=32966643

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100701A AR043487A1 (es) 2003-03-07 2004-03-05 Heterociclos fusionados de pirimidina y usos de los mismos

Country Status (25)

Country Link
US (1) US20060270689A1 (es)
EP (1) EP1601673B1 (es)
JP (2) JP3947758B2 (es)
KR (1) KR20050107784A (es)
AR (1) AR043487A1 (es)
AT (1) ATE433448T1 (es)
AU (1) AU2004218080B2 (es)
BR (1) BRPI0408150A (es)
CA (1) CA2518224C (es)
CY (1) CY1109300T1 (es)
DE (1) DE602004021477D1 (es)
DK (1) DK1601673T3 (es)
ES (1) ES2326647T3 (es)
HK (1) HK1084390A1 (es)
IS (1) IS8036A (es)
MX (1) MXPA05009577A (es)
MY (1) MY141583A (es)
NO (1) NO20054340L (es)
NZ (1) NZ542227A (es)
PL (1) PL1601673T3 (es)
PT (1) PT1601673E (es)
SI (1) SI1601673T1 (es)
TW (1) TW200510427A (es)
UA (1) UA81470C2 (es)
WO (1) WO2004078758A1 (es)

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BR0309892A2 (pt) 2002-05-09 2011-04-05 Cytokinetics Inc composto, composição, métodos para modular a atividade da cinesina de ksp, para inibir a ksp, e para o tratamento de uma doença proliferativa celular, e, uso de um composto
WO2006018628A1 (en) * 2003-03-07 2006-02-23 Astrazeneca Ab Enantiomers of selected fused pyrimidones and uses in the treatment and preventi on of cancer
WO2004087053A2 (en) * 2003-03-25 2004-10-14 Syrrx, Inc. Dipeptidyl peptidase inhibitors
US7022850B2 (en) 2003-05-22 2006-04-04 Bristol-Myers Squibb Co. Bicyclicpyrimidones and their use to treat diseases
CA2575188A1 (en) * 2004-08-18 2006-02-23 Astrazeneca Ab Enantiomers of selected fused pyrimidones and uses in the treatment and preventi on of cancer
DE602005017283D1 (de) * 2004-08-18 2009-12-03 Astrazeneca Ab Ausgewählte kondensierte heterocyclen und deren anwendung
EP1856128A4 (en) * 2005-01-19 2009-12-23 Merck & Co Inc MITOTIC INHIBITORS OF KINESIN
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Also Published As

Publication number Publication date
JP2006519853A (ja) 2006-08-31
NO20054340L (no) 2005-09-26
EP1601673A1 (en) 2005-12-07
ATE433448T1 (de) 2009-06-15
DK1601673T3 (da) 2009-08-24
CY1109300T1 (el) 2014-07-02
JP3947758B2 (ja) 2007-07-25
BRPI0408150A (pt) 2006-03-21
HK1084390A1 (en) 2006-07-28
SI1601673T1 (sl) 2009-10-31
ES2326647T3 (es) 2009-10-16
CA2518224A1 (en) 2004-09-16
JP2007063257A (ja) 2007-03-15
PT1601673E (pt) 2009-07-29
EP1601673B1 (en) 2009-06-10
DE602004021477D1 (de) 2009-07-23
AU2004218080A1 (en) 2004-09-16
UA81470C2 (en) 2008-01-10
KR20050107784A (ko) 2005-11-15
US20060270689A1 (en) 2006-11-30
AU2004218080B2 (en) 2008-01-03
MY141583A (en) 2010-05-14
WO2004078758A1 (en) 2004-09-16
CA2518224C (en) 2010-06-15
NZ542227A (en) 2008-12-24
IS8036A (is) 2005-09-19
TW200510427A (en) 2005-03-16
MXPA05009577A (es) 2005-12-12
PL1601673T3 (pl) 2009-10-30

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