PE20020599A1 - Derivados de acido amino-furan-2-il-acetico sustituido o de acido amino-tien-2-il-acetico sustituido, procedimiento para su preparacion, medicamentos que los contienen, uso de estos compuestos para la preparacion de medicamentos para el tratamiento d - Google Patents

Derivados de acido amino-furan-2-il-acetico sustituido o de acido amino-tien-2-il-acetico sustituido, procedimiento para su preparacion, medicamentos que los contienen, uso de estos compuestos para la preparacion de medicamentos para el tratamiento d

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Publication number
PE20020599A1
PE20020599A1 PE2001001195A PE2001001195A PE20020599A1 PE 20020599 A1 PE20020599 A1 PE 20020599A1 PE 2001001195 A PE2001001195 A PE 2001001195A PE 2001001195 A PE2001001195 A PE 2001001195A PE 20020599 A1 PE20020599 A1 PE 20020599A1
Authority
PE
Peru
Prior art keywords
alkyl
acetic acid
aryl
substituted amino
preparation
Prior art date
Application number
PE2001001195A
Other languages
English (en)
Inventor
Corinna Maul
Werner Englberger
Michael Przewosny
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20020599A1 publication Critical patent/PE20020599A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

SE REFIERE A DERIVADOS DE ACIDO AMINO-FURAN-2-IL-ACETICO SUSTITUIDOS O DE ACIDO AMINO-TIEN-2-IL-ACETICO SUSTITUIDO DE FORMULA I DONDE: A ES O, S; R1 ES ARILO, ALQUIL C1-C6-ARILO, HETEROCICLILO, (ALQUIL C1-C6)-HETEROCICLILO; R2 ES H, ALQUILO C1-C12, CICLOALQUILO C3-C8, ALQUIL C1-C6-CICLOALQUILO C3-C8, ARILO, ALQUILO C1-C6-ARILO, HETEROCICLILO, ALQUIL C1-C6-HETEROCICLILO; R3, R4, R5 SON H, OH, SH, F, Cl, Br, CN, NO2, ALQUILO C1-C12, CICLOALQUILO C3-C8, SiR6R7R8-(CH2)n-O-(CH2)m-R9; (CH2)o-Sp-(CH2)q-R10, (CH2)S-OCOR12; COR13; ENTRE OTROS; n, m, q, s SON 0-4; o ES 1-4; p ES 1-2; R6, R7, R8 SON ALQUILO C1-C6, FENILO; R9 Y R10 SON H, CH3, ARILO, HETEROCICLILO, CO-ALQUILO C1-C6-ARILO, CO-ARILO; R11 ES H, ALQUILO C1-C6, CH2-FENILO; R12 ES ALQUILO C1-C6, ARILO; R13 ES H, ALQUILO C1-C6, ARILO, HETEROCICLILO, NR14R15; R14 Y R15 SON H, ALQUILO C1-C6, CICLOALQUILO C3-C8, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ACIDO (5-METILSULFANILMETIL-FURAN-2-IL)-(5-NITRO-PIRIDIN-2-IL-AMINO)-ACETICO; ACIDO (5-BROMOPIRIMIDIN-2-ILAMINO)-(5-METILSULFANILMETILFURAN-2-IL)-ACETICO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS PUEDEN SER UTILES PARA EL TRATAMIENTO DEL DOLOR Y MIGRANA
PE2001001195A 2000-11-30 2001-11-29 Derivados de acido amino-furan-2-il-acetico sustituido o de acido amino-tien-2-il-acetico sustituido, procedimiento para su preparacion, medicamentos que los contienen, uso de estos compuestos para la preparacion de medicamentos para el tratamiento d PE20020599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10059864A DE10059864A1 (de) 2000-11-30 2000-11-30 Substituierte Amino-furan-2-yl-essigsäure- und Amino-thien-2-yl-essigsäure-Derivate

Publications (1)

Publication Number Publication Date
PE20020599A1 true PE20020599A1 (es) 2002-08-10

Family

ID=7665508

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001195A PE20020599A1 (es) 2000-11-30 2001-11-29 Derivados de acido amino-furan-2-il-acetico sustituido o de acido amino-tien-2-il-acetico sustituido, procedimiento para su preparacion, medicamentos que los contienen, uso de estos compuestos para la preparacion de medicamentos para el tratamiento d

Country Status (30)

Country Link
US (1) US6797712B2 (es)
EP (1) EP1341786B9 (es)
JP (1) JP4340063B2 (es)
KR (1) KR20030055334A (es)
CN (1) CN1326854C (es)
AR (1) AR035658A1 (es)
AT (1) ATE418552T1 (es)
AU (2) AU2002220735B2 (es)
BR (1) BR0115883A (es)
CA (1) CA2430280A1 (es)
CY (1) CY1108871T1 (es)
CZ (1) CZ20031509A3 (es)
DE (2) DE10059864A1 (es)
DK (1) DK1341786T3 (es)
EC (1) ECSDI034631S (es)
ES (1) ES2320198T3 (es)
HK (1) HK1059080A1 (es)
HU (1) HUP0303041A3 (es)
IL (2) IL156139A0 (es)
MX (1) MXPA03004303A (es)
NO (1) NO20032340L (es)
NZ (1) NZ526554A (es)
PE (1) PE20020599A1 (es)
PL (1) PL362978A1 (es)
PT (1) PT1341786E (es)
RU (1) RU2003117703A (es)
SI (1) SI1341786T1 (es)
SK (1) SK5942003A3 (es)
WO (1) WO2002044171A1 (es)
ZA (1) ZA200305009B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794506B2 (en) * 2000-07-21 2004-09-21 Elan Pharmaceuticals, Inc. 3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4
DE10125145A1 (de) * 2001-05-22 2002-11-28 Gruenenthal Gmbh Substituierte C-Furan-2-yl-methylamin- und C-Thiophen-2-yl-methylamin-Derivate
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
DE10306202A1 (de) * 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
DE10306203A1 (de) * 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
WO2008009079A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
US9670205B2 (en) 2015-03-04 2017-06-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
WO2018045144A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. Toll like receptor modulator compounds
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
CN115382297B (zh) * 2022-04-12 2023-10-31 江阴市华思诚无纺布有限公司 熔体直纺双组分pet纺粘液体过滤材料及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000514797A (ja) * 1996-06-28 2000-11-07 ユニバーシティ オブ サザン カリフォルニア 有機ホウ素誘導体を用いるアミンおよびアミノ酸の合成方法
US6441237B1 (en) 1999-02-20 2002-08-27 Boehringer Ingelheim Pharma Kg Substituted 3-phenoxy- and 3-phenylalkyloxy-2-phenyl-propylamines
DE19907385A1 (de) * 1999-02-20 2000-08-24 Boehringer Ingelheim Pharma Neue substituierte 3-Phenoxy- und 3-Phenylalkyloxy-2-phenyl-propylamine
GB0030304D0 (en) * 2000-12-13 2001-01-24 Lilly Co Eli Compounds

Also Published As

Publication number Publication date
CY1108871T1 (el) 2014-07-02
SK5942003A3 (en) 2003-11-04
MXPA03004303A (es) 2003-08-19
NO20032340D0 (no) 2003-05-23
DE50114605D1 (de) 2009-02-05
CA2430280A1 (en) 2002-06-06
HUP0303041A2 (hu) 2003-12-29
HK1059080A1 (en) 2004-06-18
HUP0303041A3 (en) 2007-06-28
US20040030156A1 (en) 2004-02-12
PL362978A1 (en) 2004-11-02
ES2320198T3 (es) 2009-05-20
AU2073502A (en) 2002-06-11
JP2004526675A (ja) 2004-09-02
NO20032340L (no) 2003-07-21
AR035658A1 (es) 2004-06-23
NZ526554A (en) 2005-02-25
CN1478089A (zh) 2004-02-25
DE10059864A1 (de) 2002-06-13
DK1341786T3 (da) 2009-04-20
WO2002044171A1 (de) 2002-06-06
IL156139A (en) 2007-08-19
IL156139A0 (en) 2003-12-23
EP1341786B1 (de) 2008-12-24
PT1341786E (pt) 2009-03-31
EP1341786B9 (de) 2009-08-05
RU2003117703A (ru) 2004-12-10
ECSDI034631S (es) 2003-07-25
KR20030055334A (ko) 2003-07-02
JP4340063B2 (ja) 2009-10-07
EP1341786A1 (de) 2003-09-10
US6797712B2 (en) 2004-09-28
AU2002220735B2 (en) 2007-05-10
BR0115883A (pt) 2003-12-02
ATE418552T1 (de) 2009-01-15
CZ20031509A3 (cs) 2003-09-17
ZA200305009B (en) 2004-08-18
CN1326854C (zh) 2007-07-18
SI1341786T1 (sl) 2009-04-30

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