YU49346B - TRICIKLICNI 5,6-DIHIDRO-9H-PIRAZOLO [3,4-c] -1,2,4-TRIAZOLO [4,3-α] PIRIDINI - Google Patents
TRICIKLICNI 5,6-DIHIDRO-9H-PIRAZOLO [3,4-c] -1,2,4-TRIAZOLO [4,3-α] PIRIDINIInfo
- Publication number
- YU49346B YU49346B YU34696A YU34696A YU49346B YU 49346 B YU49346 B YU 49346B YU 34696 A YU34696 A YU 34696A YU 34696 A YU34696 A YU 34696A YU 49346 B YU49346 B YU 49346B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- hydrogen
- cycloalkyl
- alkenyl
- group
- Prior art date
Links
- RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 abstract 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 abstract 1
- 125000006823 (C1-C6) acyl group Chemical group 0.000 abstract 1
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Triciklicni 5,6-dihidro-9H-pirazolo [3,4-c]-1,2,4-triazolo [4,3-α] piridini formule i njihove farmaceutski prihvatljive soli; gde R1 je vodonik, (C1-C6) alkil, (C1-C6) alkoksi, (C2-C4) alkenil, fenil, dimetilamino, (C3-C8) cikloalkil, (C3-C6) cikloalkil (C1-C3) alkil ili (C1-C6) acil, gde alkil, fenil ili alkenil grupe mogu biti supstituisane sa do dve hidroksi, (C1-C3) alkil, ili trifluorometil grupe, ili do tri halogena; R2 i R3 su svako nezavisno odabrani iz grupe koja se sastoji od vodonika, (C1-C14) alkil, (C1-C7) alkoksi (C1-C7) alkil, (C2-C14) alkenil, (C3-C7) cikloalkil, (C3-C7) cikloalkil (C1-C2) alkil, zasicena ili nezasicna (C4-C7) heterociklicna (CH2)n grupa, gde je n 0, 1 ili 2, koja sadrzi kao heteroatom jednu ili dve grupe koje sadrze kiseonik, sumpor, sulfonil, azot i NR4, gde je R4 vodonik ili (C1-C4) alkil; ili grupa formule gde je a ceo broj od 1 do 5; b i c su 0 ili 1; R5 je vodonik, hidroksi, (C1-C5) alkil, (C2-C5) alkenil, (C1-C5) alkoksi, (C3-C6) cikloalkoksi, halogen, trifluorometil, CO2R6, CONR6R7, NR6R7, NO2 ili SO2NR6R7, gde su R6 i R7 svako nezavisno vodonik ili (C1-C4) alkil; gde je Z kiseonik, sumpor, SO2, CO ili NR8, gde je R8 vodonik ili (C1-C4) alkil; a Y je (C1-C5) alkilen ili (C2-C6) alkenil opciono supstituisani sa do dve (C1-C7) alkil ili (C3-C7) cikloalkil grupe; gde svaka od alkil, alkenil, cikloalkil, alkoksialkil ili heterociklicna grupa moze biti supstituisana sa jedan do cetrnaest, pogodno jedan do pet, iz grupe koja sadrzi (C1-C2) alkil, trifluorometil ili halogen; i R9 i R10 su svako nezavisno odabrani iz grupe koja sadrzi vodonik, (C1-C6) alkil, (C1-C6) alkoksi, (C6-C10) aril i (C6-C10) ariloksi. Prijava sadrzi jos 4 zavisna zahteva.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB1995/000429 WO1996039408A1 (en) | 1995-06-06 | 1995-06-06 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO[3,4-c]-1,2,4-TRIAZOLO[4,3-α]PYRIDINES |
CA002223624A CA2223624C (en) | 1995-06-06 | 1995-06-06 | Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-.alpha.]pyridines |
HU9601541A HUP9601541A3 (en) | 1995-06-06 | 1996-06-05 | Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolol[4,3-a]-pyridines and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
YU34696A YU34696A (sh) | 1999-07-28 |
YU49346B true YU49346B (sh) | 2005-07-19 |
Family
ID=89994031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU34696A YU49346B (sh) | 1995-06-06 | 1996-06-05 | TRICIKLICNI 5,6-DIHIDRO-9H-PIRAZOLO [3,4-c] -1,2,4-TRIAZOLO [4,3-α] PIRIDINI |
Country Status (43)
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2792938B1 (fr) | 1999-04-28 | 2001-07-06 | Warner Lambert Co | NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV |
EP1380585B1 (en) * | 1999-04-30 | 2004-11-10 | Pfizer Products Inc. | Pyrazolopyridinone as intermediate |
US6326495B2 (en) * | 1999-04-30 | 2001-12-04 | Pfizer Inc. | Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein |
PT1212089E (pt) | 1999-08-21 | 2006-08-31 | Altana Pharma Ag | Combinacao sinergica de roflumilast e salmeterol |
EP1265861A2 (en) | 2000-03-16 | 2002-12-18 | Inflazyme Pharmaceuticals, Ltd. | Benzylated pde4 inhibitors |
NZ529335A (en) * | 2001-05-25 | 2005-09-30 | Pfizer | A PDE 4 inhibitor and an anti-cholinergic agent in combination for treating obstructive airways diseases |
EP1397135B1 (en) * | 2001-05-25 | 2006-12-06 | Boehringer Ingelheim Pharma GmbH & Co.KG | Combination of a pde4 inhibitor and tiotropium or derivative thereof for treating obstructive airways |
GB0122031D0 (en) * | 2001-09-12 | 2001-10-31 | Pfizer Ltd | Use of pde4 inhibitors in a dry powder inhaler |
GB0129395D0 (en) * | 2001-12-07 | 2002-01-30 | Pfizer Ltd | Pharmaceutical combination |
US20050107420A1 (en) * | 2002-05-23 | 2005-05-19 | Boehringe Ingelheim Pharma Gmbh & Co. Kg | Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases |
WO2006075748A1 (ja) * | 2005-01-17 | 2006-07-20 | Santen Pharmaceutical Co., Ltd. | アレルギー性結膜疾患治療剤 |
WO2007045979A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
RS53461B (en) | 2006-07-05 | 2014-12-31 | Takeda Gmbh | COMBINATION OF HMG-COA REDUCTASE INHIBITOR OR SIMVASTATIN WITH PHOSPHODIESTERASE 4 INHIBITOR AS A ROFLUMILAST FOR THE TREATMENT OF INFLAMMATORY PULMONARY DISEASES |
JP5579724B2 (ja) * | 2008-10-17 | 2014-08-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ホスファチジルイノシトール−3−キナーゼ(pi−3キナーゼ)阻害剤としてのテトラ−アザ−複素環 |
EP2507244B1 (en) | 2009-12-04 | 2014-11-05 | Nerviano Medical Sciences S.r.l. | Tricyclopyrazole derivatives |
WO2013084182A1 (en) | 2011-12-08 | 2013-06-13 | Glenmark Pharmaceuticals S.A. | Pharmaceutical composition that includes a pde4 enzyme inhibitor and an analgesic agent |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3697532A (en) * | 1970-08-12 | 1972-10-10 | Squibb & Sons Inc | 5-methyldipyrazolo {8 3,4-b;3{40 ,4{40 -d{9 {0 pyridin-3(2h)-ones |
RU2131876C1 (ru) * | 1993-07-06 | 1999-06-20 | Пфайзер Инк. | Бициклические тетрагидропиразолпиридины или их фармацевтически приемлемые соли, фармацевтическая композиция, способ ингибирования фосфодиэстеразы, способ лечения |
CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
-
1995
- 1995-06-06 WO PCT/IB1995/000429 patent/WO1996039408A1/en active IP Right Grant
- 1995-06-06 SK SK718-96A patent/SK282167B6/sk unknown
- 1995-06-06 DK DK95918707T patent/DK0837860T3/da active
- 1995-06-06 AT AT95918707T patent/ATE214700T1/de not_active IP Right Cessation
- 1995-06-06 ES ES95918707T patent/ES2172583T3/es not_active Expired - Lifetime
- 1995-06-06 PT PT95918707T patent/PT837860E/pt unknown
- 1995-06-06 MX MX9709897A patent/MX9709897A/es unknown
- 1995-06-06 US US08/973,590 patent/US6004974A/en not_active Expired - Fee Related
- 1995-06-06 EP EP95918707A patent/EP0837860B1/en not_active Expired - Lifetime
- 1995-06-06 CA CA002223624A patent/CA2223624C/en not_active Expired - Fee Related
- 1995-06-06 DE DE69525978T patent/DE69525978T2/de not_active Expired - Fee Related
- 1995-06-06 JP JP08511176A patent/JP3107827B2/ja not_active Expired - Fee Related
-
1996
- 1996-05-02 TW TW085105271A patent/TW460469B/zh not_active IP Right Cessation
- 1996-05-06 AP APAP/P/1996/000806A patent/AP609A/en active
- 1996-05-20 AR ARP960102626A patent/AR002745A1/es unknown
- 1996-05-27 PL PL96314459A patent/PL184195B1/pl not_active IP Right Cessation
- 1996-05-30 IL IL11848596A patent/IL118485A/xx not_active IP Right Cessation
- 1996-06-03 IS IS4350A patent/IS1913B/is unknown
- 1996-06-04 BR BR9602627A patent/BR9602627A/pt active Search and Examination
- 1996-06-04 LV LVP-96-174A patent/LV11620B/en unknown
- 1996-06-04 SA SA96170065A patent/SA96170065B1/ar unknown
- 1996-06-05 NZ NZ286734A patent/NZ286734A/en unknown
- 1996-06-05 SG SG1996009983A patent/SG54341A1/en unknown
- 1996-06-05 RU RU96111027/04A patent/RU2161158C2/ru not_active IP Right Cessation
- 1996-06-05 DZ DZ960088A patent/DZ2044A1/fr active
- 1996-06-05 KR KR1019960020169A patent/KR100191972B1/ko not_active IP Right Cessation
- 1996-06-05 MA MA24263A patent/MA23893A1/fr unknown
- 1996-06-05 TN TNTNSN96083A patent/TNSN96083A1/fr unknown
- 1996-06-05 AU AU54773/96A patent/AU694871B2/en not_active Ceased
- 1996-06-05 BG BG100640A patent/BG62568B1/bg unknown
- 1996-06-05 CZ CZ19961626A patent/CZ287251B6/cs not_active IP Right Cessation
- 1996-06-05 HU HU9601541A patent/HUP9601541A3/hu unknown
- 1996-06-05 MY MYPI96002201A patent/MY116527A/en unknown
- 1996-06-05 YU YU34696A patent/YU49346B/sh unknown
- 1996-06-05 NO NO962320A patent/NO306256B1/no unknown
- 1996-06-06 CN CN96107630A patent/CN1061044C/zh not_active Expired - Fee Related
- 1996-06-06 SI SI9600186A patent/SI9600186A/sl not_active IP Right Cessation
- 1996-06-06 RO RO96-01157A patent/RO115881B1/ro unknown
- 1996-06-06 CO CO96029521A patent/CO4700460A1/es unknown
- 1996-06-06 OA OA60834A patent/OA10458A/en unknown
- 1996-06-06 TR TR96/00482A patent/TR199600482A1/xx unknown
- 1996-06-06 HR HR960268A patent/HRP960268B1/xx not_active IP Right Cessation
-
1997
- 1997-12-05 FI FI974434A patent/FI114097B/fi active
-
1998
- 1998-10-24 KR KR1019980044720A patent/KR100225719B1/ko not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU49346B (sh) | TRICIKLICNI 5,6-DIHIDRO-9H-PIRAZOLO [3,4-c] -1,2,4-TRIAZOLO [4,3-α] PIRIDINI | |
CO4920234A1 (es) | Derivados de acidos arilsulfonilaminomidroxamicos | |
HRP20070194T3 (en) | N-thiazol-2-yl-benzamide derivatives | |
PT81898A (de) | Neue thieno-triazolo-1,4-diazepino-2-carbonsaeureamide verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen | |
ATE226189T1 (de) | Saure gruppen enthaltende phenylderivate, ihre herstellung und ihre verwendung als chloridkanalblocker | |
SE7712455L (sv) | Farmaceutiskt aktiva foreningar | |
ES2163004T3 (es) | Feniloxazolidinona sustituida por un anillo heteroaromatico como agente antimicrobiano. | |
ES2162466T3 (es) | Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen. | |
NZ512731A (en) | Tricyclic inhibitors of poly(ADP-ribose) polymerases | |
AR004516A1 (es) | Derivados de pirimidina, su uso, procedimientos para prepararlos y medicamentos que los contienen | |
AR036093A1 (es) | Compuestos derivados de tiazolidinilo, pirrolidinilo, oxazolidinilo, piperidilo, morfolinilo y tiomorfolinilo, su uso, composiciones farmaceuticas que los comprenden, y compuestos intermediarios | |
RS52562B (en) | (3-ARIL-PIPERAZINE-1-IL) DERIVATI 6,7-DIALCOKSIQUINZOLINE, 6,7-DIALCOKSIFTALAZINE I | |
CY1106497T1 (el) | Νεες αρυλοξυ-αλκυλ-διαλκυλαμινες | |
CO4900063A1 (es) | Piridinas substituidas como inhibidores selectivos de ciclo- oxi-genasa2 | |
FR2658511B1 (fr) | Nouveaux derives de benzimidazole et d'azabenzimidazole, antagonistes des recepteurs au thromboxane; leurs procedes de preparation, compositions pharmaceutiques les contenant. | |
AR010378A1 (es) | Novedosos compuestos con efecto analgesico, uso de los mismos para la preparacion de un medicamento y como agente de diagnostico, composicion farmaceutica, proceso para la preparacion de dichos compuestos y compuestos intermediarios | |
AR007108A1 (es) | Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes. | |
DK0759027T3 (da) | Bicykliske amidinderivater som inhibitorer af nitrogenoxidsynthetase | |
MX9304467A (es) | Nuevos derivados fosfonados de ariletanolaminas, procedimiento para su preparacion y composiciones farmaceuticas y veterinarias que los contienen. | |
HRP20070030T3 (en) | Derivatives of benzothiazine and benzothiadiazine, procedure for their preparation and pharmaceutical compositions containing them | |
MX9306529A (es) | Derivados de pirazol condensado, metodo para fabricarlos y composicion farmaceutica que los contiene | |
FR2632639B1 (fr) | Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent | |
SE7706346L (sv) | Bensaminderivat | |
ATE24509T1 (de) | Triazoloquinazolone und deren salze, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zusammensetzungen. | |
CO5080802A1 (es) | Nuevos compuestos heterociclicos inhibidores de la fosfodiesteresa iv y su formulacion y uso como productos farmaceuticos |