KR100225719B1 - Pharmaceutical compositions containing tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo-[4,3-alpha]pyridines - Google Patents

Pharmaceutical compositions containing tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo-[4,3-alpha]pyridines Download PDF

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Publication number
KR100225719B1
KR100225719B1 KR1019980044720A KR19980044720A KR100225719B1 KR 100225719 B1 KR100225719 B1 KR 100225719B1 KR 1019980044720 A KR1019980044720 A KR 1019980044720A KR 19980044720 A KR19980044720 A KR 19980044720A KR 100225719 B1 KR100225719 B1 KR 100225719B1
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KR
South Korea
Prior art keywords
triazolo
pyrazolo
pyridines
dihydro
alpha
Prior art date
Application number
KR1019980044720A
Other languages
English (en)
Inventor
Allen Jacob Duplantier
Kelvin Cooper
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of KR100225719B1 publication Critical patent/KR100225719B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019980044720A 1995-06-06 1998-10-24 Pharmaceutical compositions containing tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo-[4,3-alpha]pyridines KR100225719B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/IB1995/000429 WO1996039408A1 (en) 1995-06-06 1995-06-06 TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO[3,4-c]-1,2,4-TRIAZOLO[4,3-α]PYRIDINES
CA002223624A CA2223624C (en) 1995-06-06 1995-06-06 Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-.alpha.]pyridines
KR1019960020169A KR100191972B1 (ko) 1995-06-06 1996-06-05 삼환5,6-디하이드로-9h-피라졸로[3,4-c]-1,2,4-트리아졸로[4,3-a]피리딘
HU9601541A HUP9601541A3 (en) 1995-06-06 1996-06-05 Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolol[4,3-a]-pyridines and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
KR100225719B1 true KR100225719B1 (en) 1999-10-15

Family

ID=89994031

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019960020169A KR100191972B1 (ko) 1995-06-06 1996-06-05 삼환5,6-디하이드로-9h-피라졸로[3,4-c]-1,2,4-트리아졸로[4,3-a]피리딘
KR1019980044720A KR100225719B1 (en) 1995-06-06 1998-10-24 Pharmaceutical compositions containing tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo-[4,3-alpha]pyridines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019960020169A KR100191972B1 (ko) 1995-06-06 1996-06-05 삼환5,6-디하이드로-9h-피라졸로[3,4-c]-1,2,4-트리아졸로[4,3-a]피리딘

Country Status (43)

Country Link
US (1) US6004974A (ko)
EP (1) EP0837860B1 (ko)
JP (1) JP3107827B2 (ko)
KR (2) KR100191972B1 (ko)
CN (1) CN1061044C (ko)
AP (1) AP609A (ko)
AR (1) AR002745A1 (ko)
AT (1) ATE214700T1 (ko)
AU (1) AU694871B2 (ko)
BG (1) BG62568B1 (ko)
BR (1) BR9602627A (ko)
CA (1) CA2223624C (ko)
CO (1) CO4700460A1 (ko)
CZ (1) CZ287251B6 (ko)
DE (1) DE69525978T2 (ko)
DK (1) DK0837860T3 (ko)
DZ (1) DZ2044A1 (ko)
ES (1) ES2172583T3 (ko)
FI (1) FI114097B (ko)
HR (1) HRP960268B1 (ko)
HU (1) HUP9601541A3 (ko)
IL (1) IL118485A (ko)
IS (1) IS1913B (ko)
LV (1) LV11620B (ko)
MA (1) MA23893A1 (ko)
MX (1) MX9709897A (ko)
MY (1) MY116527A (ko)
NO (1) NO306256B1 (ko)
NZ (1) NZ286734A (ko)
OA (1) OA10458A (ko)
PL (1) PL184195B1 (ko)
PT (1) PT837860E (ko)
RO (1) RO115881B1 (ko)
RU (1) RU2161158C2 (ko)
SA (1) SA96170065B1 (ko)
SG (1) SG54341A1 (ko)
SI (1) SI9600186A (ko)
SK (1) SK282167B6 (ko)
TN (1) TNSN96083A1 (ko)
TR (1) TR199600482A1 (ko)
TW (1) TW460469B (ko)
WO (1) WO1996039408A1 (ko)
YU (1) YU49346B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2792938B1 (fr) * 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
EP1380585B1 (en) * 1999-04-30 2004-11-10 Pfizer Products Inc. Pyrazolopyridinone as intermediate
US6326495B2 (en) * 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
EA006685B1 (ru) 1999-08-21 2006-02-24 Алтана Фарма Аг Синергетическая композиция
EP2258689A1 (en) * 2000-03-16 2010-12-08 Biolipox AB Benzylated PDE4 inhibitors
CA2446613A1 (en) * 2001-05-25 2002-12-05 Pfizer Inc. A pde 4 inhibitor and an anti-cholinergic agent in combination for treating obstructive airways diseases
JP2004530705A (ja) * 2001-05-25 2004-10-07 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 閉塞性気道疾患及びその他の炎症性疾患を治療するためのｐｄｅ４インヒビター及びチオトロピウム又はその誘導体の組み合わせ
GB0122031D0 (en) * 2001-09-12 2001-10-31 Pfizer Ltd Use of pde4 inhibitors in a dry powder inhaler
GB0129395D0 (en) * 2001-12-07 2002-01-30 Pfizer Ltd Pharmaceutical combination
US20050107420A1 (en) * 2002-05-23 2005-05-19 Boehringe Ingelheim Pharma Gmbh & Co. Kg Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases
WO2006075748A1 (ja) * 2005-01-17 2006-07-20 Santen Pharmaceutical Co., Ltd. アレルギー性結膜疾患治療剤
AU2006305619A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
UA98466C2 (uk) 2006-07-05 2012-05-25 Нікомед Гмбх КОМБІНАЦІЯ ІНГІБІТОРА HMG-CоA-РЕДУКТАЗИ Й ІНГІБІТОРА ФОСФОДІЕСТЕРАЗИ 4, ПРИЗНАЧЕНА ДЛЯ ЛІКУВАННЯ ЗАПАЛЬНИХ ЗАХВОРЮВАНЬ ЛЕГЕНІВ
CA2739148A1 (en) * 2008-10-17 2010-04-22 Boehringer Ingelheim International Gmbh Tetra-aza-heterocycles as phosphatidylinositol-3-kinases (pi3-kinases) inhibitor
WO2011067145A1 (en) 2009-12-04 2011-06-09 Nerviano Medical Sciences S.R.L. Tricyclopyrazole derivatives
WO2013084182A1 (en) 2011-12-08 2013-06-13 Glenmark Pharmaceuticals S.A. Pharmaceutical composition that includes a pde4 enzyme inhibitor and an analgesic agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697532A (en) * 1970-08-12 1972-10-10 Squibb & Sons Inc 5-methyldipyrazolo {8 3,4-b;3{40 ,4{40 -d{9 {0 pyridin-3(2h)-ones
RU2131876C1 (ru) * 1993-07-06 1999-06-20 Пфайзер Инк. Бициклические тетрагидропиразолпиридины или их фармацевтически приемлемые соли, фармацевтическая композиция, способ ингибирования фосфодиэстеразы, способ лечения
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives

Also Published As

Publication number Publication date
BR9602627A (pt) 1998-09-01
CA2223624C (en) 2001-02-20
SG54341A1 (en) 1998-11-16
KR970003440A (ko) 1997-01-28
PL184195B1 (pl) 2002-09-30
JPH10510242A (ja) 1998-10-06
NO962320L (no) 1996-12-09
CN1142499A (zh) 1997-02-12
IL118485A (en) 2000-02-17
IL118485A0 (en) 1996-09-12
WO1996039408A1 (en) 1996-12-12
NO962320D0 (no) 1996-06-05
TW460469B (en) 2001-10-21
PL314459A1 (en) 1996-12-09
HRP960268A2 (en) 1997-08-31
DE69525978T2 (de) 2002-12-19
HU9601541D0 (en) 1996-07-29
EP0837860B1 (en) 2002-03-20
IS4350A (is) 1996-12-07
CA2223624A1 (en) 1996-12-12
OA10458A (en) 2002-03-27
HUP9601541A2 (en) 1997-02-28
EP0837860A1 (en) 1998-04-29
SK71896A3 (en) 1997-05-07
CZ162696A3 (en) 1997-01-15
US6004974A (en) 1999-12-21
SI9600186A (en) 1997-04-30
JP3107827B2 (ja) 2000-11-13
HRP960268B1 (en) 2002-12-31
RO115881B1 (ro) 2000-07-28
AP609A (en) 1997-09-03
BG100640A (bg) 1997-03-31
DK0837860T3 (da) 2002-05-27
ES2172583T3 (es) 2002-10-01
IS1913B (is) 2004-02-03
YU34696A (sh) 1999-07-28
YU49346B (sh) 2005-07-19
ATE214700T1 (de) 2002-04-15
CZ287251B6 (en) 2000-10-11
TR199600482A1 (tr) 1997-03-21
FI974434A0 (fi) 1997-12-05
CN1061044C (zh) 2001-01-24
AP9600806A0 (en) 1996-07-31
LV11620A (lv) 1996-12-20
FI974434A (fi) 1997-12-05
NO306256B1 (no) 1999-10-11
AR002745A1 (es) 1998-04-29
NZ286734A (en) 1998-02-26
PT837860E (pt) 2002-07-31
SA96170065B1 (ar) 2005-12-21
LV11620B (en) 1997-04-20
CO4700460A1 (es) 1998-12-29
SK282167B6 (sk) 2001-11-06
HUP9601541A3 (en) 1997-05-28
DE69525978D1 (de) 2002-04-25
AU5477396A (en) 1996-12-19
FI114097B (fi) 2004-08-13
BG62568B1 (bg) 2000-02-29
AU694871B2 (en) 1998-07-30
MY116527A (en) 2004-02-28
TNSN96083A1 (fr) 2005-03-15
MA23893A1 (fr) 1996-12-31
DZ2044A1 (fr) 2002-07-21
KR100191972B1 (ko) 1999-06-15
MX9709897A (es) 1998-03-31
RU2161158C2 (ru) 2000-12-27

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