YU34696A - TRICIKLICNI 5,6-DIHIDRO-9H-PIRAZOLO(3,4-C)-1,2,4-TRIAZOLO (4,3α) PIRIDINI - Google Patents

TRICIKLICNI 5,6-DIHIDRO-9H-PIRAZOLO(3,4-C)-1,2,4-TRIAZOLO (4,3α) PIRIDINI

Info

Publication number
YU34696A
YU34696A YU34696A YU34696A YU34696A YU 34696 A YU34696 A YU 34696A YU 34696 A YU34696 A YU 34696A YU 34696 A YU34696 A YU 34696A YU 34696 A YU34696 A YU 34696A
Authority
YU
Yugoslavia
Prior art keywords
pde
compound
formula
triazolo
pyrazolo
Prior art date
Application number
YU34696A
Other languages
English (en)
Other versions
YU49346B (sh
Inventor
Allen Jacob Duplantier
Celvin Cooper
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU34696A publication Critical patent/YU34696A/sh
Publication of YU49346B publication Critical patent/YU49346B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Jedinjenje formule u kojoj R1, R2, R3, R9 i R10 su kako je gore definisano. Jedinjenje formule I i njegove farmaceutski prihvatljive soli korisni su u inhibiranju fosfodiesteraze (PDE) tipa IV i dobijanja faktora nekroze tumora (TNF) i u tretiranju astme, artritisa, bronhitisa, hronične opstruktivne bolesti vazdušnih puteva, psorijaze, alergijskog rinitisa, dermatitisa i drugih inflamatornih bolesti okarakterisanih aktivnošću fosfodiesteraze (PDE) tipa IV, kao i SIDE, sepse, septičkog šoka i drugih bolesti, kao što je kaheksija, koji uključuju dibjanje TNF.
YU34696A 1995-06-06 1996-06-05 TRICIKLICNI 5,6-DIHIDRO-9H-PIRAZOLO [3,4-c] -1,2,4-TRIAZOLO [4,3-α] PIRIDINI YU49346B (sh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/IB1995/000429 WO1996039408A1 (en) 1995-06-06 1995-06-06 TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO[3,4-c]-1,2,4-TRIAZOLO[4,3-α]PYRIDINES
CA002223624A CA2223624C (en) 1995-06-06 1995-06-06 Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-.alpha.]pyridines
HU9601541A HUP9601541A3 (en) 1995-06-06 1996-06-05 Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolol[4,3-a]-pyridines and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
YU34696A true YU34696A (sh) 1999-07-28
YU49346B YU49346B (sh) 2005-07-19

Family

ID=89994031

Family Applications (1)

Application Number Title Priority Date Filing Date
YU34696A YU49346B (sh) 1995-06-06 1996-06-05 TRICIKLICNI 5,6-DIHIDRO-9H-PIRAZOLO [3,4-c] -1,2,4-TRIAZOLO [4,3-α] PIRIDINI

Country Status (43)

Country Link
US (1) US6004974A (sh)
EP (1) EP0837860B1 (sh)
JP (1) JP3107827B2 (sh)
KR (2) KR100191972B1 (sh)
CN (1) CN1061044C (sh)
AP (1) AP609A (sh)
AR (1) AR002745A1 (sh)
AT (1) ATE214700T1 (sh)
AU (1) AU694871B2 (sh)
BG (1) BG62568B1 (sh)
BR (1) BR9602627A (sh)
CA (1) CA2223624C (sh)
CO (1) CO4700460A1 (sh)
CZ (1) CZ287251B6 (sh)
DE (1) DE69525978T2 (sh)
DK (1) DK0837860T3 (sh)
DZ (1) DZ2044A1 (sh)
ES (1) ES2172583T3 (sh)
FI (1) FI114097B (sh)
HR (1) HRP960268B1 (sh)
HU (1) HUP9601541A3 (sh)
IL (1) IL118485A (sh)
IS (1) IS1913B (sh)
LV (1) LV11620B (sh)
MA (1) MA23893A1 (sh)
MX (1) MX9709897A (sh)
MY (1) MY116527A (sh)
NO (1) NO306256B1 (sh)
NZ (1) NZ286734A (sh)
OA (1) OA10458A (sh)
PL (1) PL184195B1 (sh)
PT (1) PT837860E (sh)
RO (1) RO115881B1 (sh)
RU (1) RU2161158C2 (sh)
SA (1) SA96170065B1 (sh)
SG (1) SG54341A1 (sh)
SI (1) SI9600186A (sh)
SK (1) SK282167B6 (sh)
TN (1) TNSN96083A1 (sh)
TR (1) TR199600482A1 (sh)
TW (1) TW460469B (sh)
WO (1) WO1996039408A1 (sh)
YU (1) YU49346B (sh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2792938B1 (fr) 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
EP1380585B1 (en) * 1999-04-30 2004-11-10 Pfizer Products Inc. Pyrazolopyridinone as intermediate
US6326495B2 (en) * 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
PT1212089E (pt) 1999-08-21 2006-08-31 Altana Pharma Ag Combinacao sinergica de roflumilast e salmeterol
EP1265861A2 (en) 2000-03-16 2002-12-18 Inflazyme Pharmaceuticals, Ltd. Benzylated pde4 inhibitors
NZ529335A (en) * 2001-05-25 2005-09-30 Pfizer A PDE 4 inhibitor and an anti-cholinergic agent in combination for treating obstructive airways diseases
EP1397135B1 (en) * 2001-05-25 2006-12-06 Boehringer Ingelheim Pharma GmbH & Co.KG Combination of a pde4 inhibitor and tiotropium or derivative thereof for treating obstructive airways
GB0122031D0 (en) * 2001-09-12 2001-10-31 Pfizer Ltd Use of pde4 inhibitors in a dry powder inhaler
GB0129395D0 (en) * 2001-12-07 2002-01-30 Pfizer Ltd Pharmaceutical combination
US20050107420A1 (en) * 2002-05-23 2005-05-19 Boehringe Ingelheim Pharma Gmbh & Co. Kg Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases
WO2006075748A1 (ja) * 2005-01-17 2006-07-20 Santen Pharmaceutical Co., Ltd. アレルギー性結膜疾患治療剤
WO2007045979A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
RS53461B (en) 2006-07-05 2014-12-31 Takeda Gmbh COMBINATION OF HMG-COA REDUCTASE INHIBITOR OR SIMVASTATIN WITH PHOSPHODIESTERASE 4 INHIBITOR AS A ROFLUMILAST FOR THE TREATMENT OF INFLAMMATORY PULMONARY DISEASES
JP5579724B2 (ja) * 2008-10-17 2014-08-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ホスファチジルイノシトール−３−キナーゼ（ｐｉ−３キナーゼ）阻害剤としてのテトラ−アザ−複素環
EP2507244B1 (en) 2009-12-04 2014-11-05 Nerviano Medical Sciences S.r.l. Tricyclopyrazole derivatives
WO2013084182A1 (en) 2011-12-08 2013-06-13 Glenmark Pharmaceuticals S.A. Pharmaceutical composition that includes a pde4 enzyme inhibitor and an analgesic agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697532A (en) * 1970-08-12 1972-10-10 Squibb & Sons Inc 5-methyldipyrazolo {8 3,4-b;3{40 ,4{40 -d{9 {0 pyridin-3(2h)-ones
RU2131876C1 (ru) * 1993-07-06 1999-06-20 Пфайзер Инк. Бициклические тетрагидропиразолпиридины или их фармацевтически приемлемые соли, фармацевтическая композиция, способ ингибирования фосфодиэстеразы, способ лечения
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives

Also Published As

Publication number Publication date
NO962320D0 (no) 1996-06-05
KR100225719B1 (en) 1999-10-15
DE69525978D1 (de) 2002-04-25
AU5477396A (en) 1996-12-19
NZ286734A (en) 1998-02-26
RO115881B1 (ro) 2000-07-28
JP3107827B2 (ja) 2000-11-13
EP0837860A1 (en) 1998-04-29
DK0837860T3 (da) 2002-05-27
ES2172583T3 (es) 2002-10-01
WO1996039408A1 (en) 1996-12-12
TW460469B (en) 2001-10-21
MX9709897A (es) 1998-03-31
CZ287251B6 (en) 2000-10-11
RU2161158C2 (ru) 2000-12-27
MA23893A1 (fr) 1996-12-31
HU9601541D0 (en) 1996-07-29
PT837860E (pt) 2002-07-31
SA96170065B1 (ar) 2005-12-21
CZ162696A3 (en) 1997-01-15
HUP9601541A3 (en) 1997-05-28
US6004974A (en) 1999-12-21
DZ2044A1 (fr) 2002-07-21
PL314459A1 (en) 1996-12-09
SI9600186A (en) 1997-04-30
EP0837860B1 (en) 2002-03-20
ATE214700T1 (de) 2002-04-15
CO4700460A1 (es) 1998-12-29
CN1061044C (zh) 2001-01-24
DE69525978T2 (de) 2002-12-19
BG100640A (bg) 1997-03-31
NO962320L (no) 1996-12-09
IS1913B (is) 2004-02-03
AU694871B2 (en) 1998-07-30
YU49346B (sh) 2005-07-19
FI974434A (fi) 1997-12-05
CA2223624A1 (en) 1996-12-12
LV11620B (en) 1997-04-20
TR199600482A1 (tr) 1997-03-21
LV11620A (lv) 1996-12-20
BG62568B1 (bg) 2000-02-29
JPH10510242A (ja) 1998-10-06
AP9600806A0 (en) 1996-07-31
HRP960268A2 (en) 1997-08-31
MY116527A (en) 2004-02-28
TNSN96083A1 (fr) 2005-03-15
SK282167B6 (sk) 2001-11-06
FI114097B (fi) 2004-08-13
AP609A (en) 1997-09-03
CA2223624C (en) 2001-02-20
IL118485A0 (en) 1996-09-12
OA10458A (en) 2002-03-27
SG54341A1 (en) 1998-11-16
KR970003440A (ko) 1997-01-28
BR9602627A (pt) 1998-09-01
AR002745A1 (es) 1998-04-29
PL184195B1 (pl) 2002-09-30
FI974434A0 (fi) 1997-12-05
HUP9601541A2 (en) 1997-02-28
IS4350A (is) 1996-12-07
SK71896A3 (en) 1997-05-07
IL118485A (en) 2000-02-17
NO306256B1 (no) 1999-10-11
HRP960268B1 (en) 2002-12-31
CN1142499A (zh) 1997-02-12
KR100191972B1 (ko) 1999-06-15

Similar Documents

Publication Publication Date Title
YU34696A (sh) TRICIKLICNI 5,6-DIHIDRO-9H-PIRAZOLO(3,4-C)-1,2,4-TRIAZOLO (4,3α) PIRIDINI
CA2166721A1 (en) Bicyclic tetrahydro pyrazolopyridines
MX9504422A (es) Tetrahidropirazolopiridinas biciclicas.
BR0010783A (pt) Novos compostos, seu uso e preparação
FI945555A0 (fi) Substituoituja oksindoleja
DE69410121D1 (en) Dihydro pyrazolopyrrole
CA2150812A1 (en) Catechol diethers as selective pde iv inhibitors
RU96103653A (ru) Бициклические тетрагидропиразолопиридины
HRP20080306B1 (hr) Derivati 4-fenil-piridina
GEP20033029B (en) Substituted 1,8-Naphthyridin-4(1H)-Ones as Phosphodiesterase 4 Inhibitors
ATE256128T1 (de) Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung
JP2006512293A5 (sh)
HUP0303034A2 (hu) Új 7-azaindol-származékok, foszfodiészteráz-4 inhibitorjakénti alkalmazásuk és eljárás az előállításukra
CA2223245A1 (en) Catechol diethers derivatives useful as pharmaceutical agents
BR0010693A (pt) Derivados azaindol para tratamento de depressão
CA2402446A1 (en) 1,8-naphthalimide imidazo[4,5,1-de]acridones with anti-tumor activity
US4837238A (en) Pharmacologically useful pyrazolopyridines
EP0276833B1 (en) Dipyrazoles useful as bronchodilators
MY135666A (en) Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
ECSP961759A (es) 5,6 dihidro -9h- pirazol (3,4-c)-1,2,4- triazol (4- 3 -a) piridinas triciclicas
IL75012A (en) 6-substituted-(1,3,4)-thiadiazolo(and thiazolo)(3,2-a)(1,2,3)triazolo(4,5-d)pyrimidine-9(1h)-ones
YU13093A (sh) Biciklični heterociklični derivati