CA2166721A1 - Bicyclic tetrahydro pyrazolopyridines - Google Patents
Bicyclic tetrahydro pyrazolopyridinesInfo
- Publication number
- CA2166721A1 CA2166721A1 CA2166721A CA2166721A CA2166721A1 CA 2166721 A1 CA2166721 A1 CA 2166721A1 CA 2166721 A CA2166721 A CA 2166721A CA 2166721 A CA2166721 A CA 2166721A CA 2166721 A1 CA2166721 A1 CA 2166721A1
- Authority
- CA
- Canada
- Prior art keywords
- tnf
- compounds
- formula
- production
- pyrazolopyridines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Compounds of formula (I) wherein R1, R2, R3 and X
are as defined. The compounds of formula (I) and the pharmaceutically acceptable salts thereof are useful in inhibiting phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) and in the treatment of asthma, arthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases, AIDS, septic shock and other diseases involving the production of TNF.
are as defined. The compounds of formula (I) and the pharmaceutically acceptable salts thereof are useful in inhibiting phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) and in the treatment of asthma, arthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases, AIDS, septic shock and other diseases involving the production of TNF.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8829293A | 1993-07-06 | 1993-07-06 | |
US08/088,292 | 1993-07-06 | ||
PCT/IB1994/000156 WO1995001980A1 (en) | 1993-07-06 | 1994-06-16 | Bicyclic tetrahydro pyrazolopyridines |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2166721A1 true CA2166721A1 (en) | 1995-01-19 |
CA2166721C CA2166721C (en) | 1999-07-27 |
Family
ID=22210524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002166721A Expired - Fee Related CA2166721C (en) | 1993-07-06 | 1994-06-16 | Bicyclic tetrahydro pyrazolopyridines |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0707585A1 (en) |
JP (1) | JP2944048B2 (en) |
KR (1) | KR100228949B1 (en) |
CN (1) | CN1048015C (en) |
AU (1) | AU695301B2 (en) |
BR (1) | BR9406946A (en) |
CA (1) | CA2166721C (en) |
CZ (1) | CZ3696A3 (en) |
EG (1) | EG20513A (en) |
FI (1) | FI943208A (en) |
HU (1) | HUT74170A (en) |
IL (1) | IL110175A (en) |
MX (1) | MX9405132A (en) |
NO (1) | NO305029B1 (en) |
NZ (1) | NZ266525A (en) |
PL (1) | PL312426A1 (en) |
RU (1) | RU2131876C1 (en) |
TW (1) | TW316904B (en) |
WO (1) | WO1995001980A1 (en) |
ZA (1) | ZA944844B (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU702105B2 (en) * | 1994-10-20 | 1999-02-11 | Pfizer Inc. | Bicyclic tetrahydro pyrazolopyridines and their use as medicaments |
DE69525978T2 (en) * | 1995-06-06 | 2002-12-19 | Pfizer | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO (3,4-C) -1,2,4-TRIAZOLO (4,3-ALPHA) PYRIDINE |
AP932A (en) * | 1996-08-26 | 2001-02-02 | Pfizer | Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines. |
PL332187A1 (en) * | 1996-09-04 | 1999-08-30 | Pfizer | Substitution derivatives of indazole and their application as inhibitors of phosphodiesterase (pde) of iv type and tumor necrosis factor (tnf) |
US6858616B2 (en) | 1998-12-23 | 2005-02-22 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor Xa inhibitors |
ES2232202T3 (en) * | 1998-12-23 | 2005-05-16 | Bristol-Myers Squibb Pharma Company | HETEROBICICLES CONTAINING NITROGEN AS INHIBITORS OF THE XA FACTOR. |
US6326495B2 (en) | 1999-04-30 | 2001-12-04 | Pfizer Inc. | Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein |
PL200923B1 (en) | 1999-08-21 | 2009-02-27 | Nycomed Gmbh | SYNERGISTIC COMBINATION OF PDE INHIBITORS AND ß₂ ADRENOCEPTOR AGONIST |
TWI243055B (en) * | 2000-04-13 | 2005-11-11 | Nippon Zoki Pharmaceutical Co | Pharmaceutical composition for use in treatment of dermatitis |
PL213199B1 (en) * | 2000-08-10 | 2013-01-31 | Pharmacia Italia Spa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
US6960595B2 (en) * | 2001-03-23 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | 5-6 to 5-7 Heterobicycles as factor Xa inhibitors |
EP1379245A4 (en) | 2001-04-18 | 2006-07-26 | Bristol Myers Squibb Co | 1, 4, 5, 6-tetrahydropyrazolo- 3, 4-c|-pyrid in-7-ones as factor xa inhibitors |
WO2002085353A1 (en) | 2001-04-18 | 2002-10-31 | Bristol-Myers Squibb Company | 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor xa inhibitors |
JP4196678B2 (en) | 2001-04-26 | 2008-12-17 | 味の素株式会社 | Heterocyclic compounds |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
UA81453C2 (en) | 2003-02-27 | 2008-01-10 | Pyrazolopyridine derivates | |
US7135469B2 (en) * | 2003-03-18 | 2006-11-14 | Bristol Myers Squibb, Co. | Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors |
CA2517487A1 (en) | 2003-04-01 | 2004-10-14 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
DE102005031580A1 (en) * | 2005-07-06 | 2007-01-11 | Aicuris Gmbh & Co. Kg | Substituted sulfolanylpyrazoles and their use |
AR065804A1 (en) * | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | COMPOSITE OF INDOL CARBOXAMIDE, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT AND USE OF THIS COMPOUND TO PREPARE A MEDICINAL PRODUCT |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EA020466B1 (en) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
JP2011522828A (en) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders |
CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CA2828346C (en) | 2011-03-01 | 2021-01-26 | Synergy Pharmaceuticals Inc. | Process of preparing guanylate cyclase c agonists |
AU2014218599C1 (en) | 2013-02-25 | 2018-09-06 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists for use in colonic cleansing |
JP2016514670A (en) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | Guanylate cyclase receptor agonists in combination with other drugs |
AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
KR102272746B1 (en) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
MX2016001714A (en) | 2013-08-09 | 2016-10-03 | Ardelyx Inc | Compounds and methods for inhibiting phosphate transport. |
CN110357888A (en) * | 2018-04-09 | 2019-10-22 | 南京药捷安康生物科技有限公司 | Heterocycle phosphodiesterase inhibitors and application thereof |
JP2022533251A (en) | 2019-05-21 | 2022-07-21 | アルデリックス, インコーポレイテッド | Combinations to lower serum phosphate in patients |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1463883A (en) * | 1964-09-08 | 1966-07-22 | Ciba Geigy | Process for the preparation of bicyclic triaza-compounds |
US3365459A (en) * | 1964-09-08 | 1968-01-23 | Ciba Geigy Corp | Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives |
US3340269A (en) * | 1964-09-08 | 1967-09-05 | Ciba Geigy Corp | 1-substituted 4-acyl-2, 3-dioxo-piperidine |
US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
-
1994
- 1994-06-16 BR BR9406946A patent/BR9406946A/en not_active Application Discontinuation
- 1994-06-16 KR KR1019960700019A patent/KR100228949B1/en not_active IP Right Cessation
- 1994-06-16 EP EP94916370A patent/EP0707585A1/en not_active Withdrawn
- 1994-06-16 HU HU9503934A patent/HUT74170A/en unknown
- 1994-06-16 NZ NZ266525A patent/NZ266525A/en unknown
- 1994-06-16 CA CA002166721A patent/CA2166721C/en not_active Expired - Fee Related
- 1994-06-16 CN CN94193233A patent/CN1048015C/en not_active Expired - Fee Related
- 1994-06-16 AU AU68057/94A patent/AU695301B2/en not_active Ceased
- 1994-06-16 PL PL94312426A patent/PL312426A1/en unknown
- 1994-06-16 CZ CZ9636A patent/CZ3696A3/en unknown
- 1994-06-16 WO PCT/IB1994/000156 patent/WO1995001980A1/en not_active Application Discontinuation
- 1994-06-16 JP JP7503938A patent/JP2944048B2/en not_active Expired - Lifetime
- 1994-06-16 RU RU96103653A patent/RU2131876C1/en active
- 1994-06-17 TW TW083105518A patent/TW316904B/zh active
- 1994-06-30 IL IL11017594A patent/IL110175A/en active IP Right Grant
- 1994-07-05 FI FI943208A patent/FI943208A/en unknown
- 1994-07-05 EG EG40294A patent/EG20513A/en active
- 1994-07-05 ZA ZA944844A patent/ZA944844B/en unknown
- 1994-07-05 MX MX9405132A patent/MX9405132A/en unknown
-
1996
- 1996-01-05 NO NO960056A patent/NO305029B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR100228949B1 (en) | 1999-11-01 |
AU695301B2 (en) | 1998-08-13 |
ZA944844B (en) | 1996-01-05 |
PL312426A1 (en) | 1996-04-29 |
CA2166721C (en) | 1999-07-27 |
IL110175A0 (en) | 1994-10-07 |
CN1129940A (en) | 1996-08-28 |
HU9503934D0 (en) | 1996-03-28 |
FI943208A (en) | 1995-01-07 |
HUT74170A (en) | 1996-11-28 |
AU6805794A (en) | 1995-02-06 |
WO1995001980A1 (en) | 1995-01-19 |
NO960056D0 (en) | 1996-01-05 |
EP0707585A1 (en) | 1996-04-24 |
MX9405132A (en) | 1995-01-31 |
JPH08507084A (en) | 1996-07-30 |
BR9406946A (en) | 1996-08-06 |
NO305029B1 (en) | 1999-03-22 |
RU2131876C1 (en) | 1999-06-20 |
TW316904B (en) | 1997-10-01 |
NO960056L (en) | 1996-01-05 |
CN1048015C (en) | 2000-01-05 |
IL110175A (en) | 2000-01-31 |
EG20513A (en) | 1999-06-30 |
JP2944048B2 (en) | 1999-08-30 |
CZ3696A3 (en) | 1997-06-11 |
FI943208A0 (en) | 1994-07-05 |
NZ266525A (en) | 1997-10-24 |
KR960703852A (en) | 1996-08-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |