ATE256128T1 - Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung - Google Patents
Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendungInfo
- Publication number
- ATE256128T1 ATE256128T1 AT99949322T AT99949322T ATE256128T1 AT E256128 T1 ATE256128 T1 AT E256128T1 AT 99949322 T AT99949322 T AT 99949322T AT 99949322 T AT99949322 T AT 99949322T AT E256128 T1 ATE256128 T1 AT E256128T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- substituent
- optionally
- atom
- hydrogen atom
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical class C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 9
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000002252 acyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000003266 anti-allergic effect Effects 0.000 abstract 3
- 230000001387 anti-histamine Effects 0.000 abstract 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 3
- 239000000739 antihistaminic agent Substances 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 230000013764 eosinophil chemotaxis Effects 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 206010010744 Conjunctivitis allergic Diseases 0.000 abstract 2
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 2
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 2
- 206010052568 Urticaria chronic Diseases 0.000 abstract 2
- 208000002205 allergic conjunctivitis Diseases 0.000 abstract 2
- 201000010105 allergic rhinitis Diseases 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 208000024998 atopic conjunctivitis Diseases 0.000 abstract 2
- 201000008937 atopic dermatitis Diseases 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 208000024376 chronic urticaria Diseases 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 150000002430 hydrocarbons Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical group [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 206010012442 Dermatitis contact Diseases 0.000 abstract 1
- 206010037083 Prurigo Diseases 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 208000010247 contact dermatitis Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical group [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29942498 | 1998-10-21 | ||
| JP29942598 | 1998-10-21 | ||
| JP30731798 | 1998-10-28 | ||
| PCT/JP1999/005786 WO2000023450A1 (en) | 1998-10-21 | 1999-10-20 | Fused pyridazine derivatives, process for the preparation of the same and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE256128T1 true ATE256128T1 (de) | 2003-12-15 |
Family
ID=27338303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99949322T ATE256128T1 (de) | 1998-10-21 | 1999-10-20 | Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6627630B1 (de) |
| EP (1) | EP1123936B1 (de) |
| KR (1) | KR20010087738A (de) |
| CN (1) | CN1329614A (de) |
| AT (1) | ATE256128T1 (de) |
| AU (1) | AU6227399A (de) |
| CA (1) | CA2348022A1 (de) |
| DE (1) | DE69913558T2 (de) |
| WO (1) | WO2000023450A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1426050A4 (de) * | 2001-08-23 | 2005-05-25 | Takeda Pharmaceutical | Jnk-hemmer |
| US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| AU2002357506A1 (en) * | 2001-12-25 | 2003-07-15 | Takeda Chemical Industries, Ltd. | Acid-containing preparations |
| JP4550353B2 (ja) * | 2002-07-24 | 2010-09-22 | 株式会社医薬分子設計研究所 | 造血器型プロスタグランジンｄ２合成酵素阻害剤 |
| KR101027360B1 (ko) * | 2002-07-29 | 2011-04-11 | 스미또모 가가꾸 가부시끼가이샤 | 이미다조[1,2-ｂ]피리다진 유도체의 신규한 제조 방법 |
| EP1541575B1 (de) * | 2002-07-29 | 2010-03-03 | Sumitomo Chemical Company, Limited | Neues verfahren zur herstellung eines imidazo(1,2-b)pyridazinderivats |
| US7235556B2 (en) | 2003-04-16 | 2007-06-26 | Alcon, Inc. | Methods of treating dry eye disorders |
| EP2316827B1 (de) * | 2003-07-30 | 2016-01-27 | Xenon Pharmaceuticals Inc. | Piperazin derivate und deren anwendung als therapeutische wirkstoffe |
| JP4958787B2 (ja) * | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリジン誘導体 |
| EP1799667B1 (de) | 2004-09-20 | 2013-03-20 | Xenon Pharmaceuticals Inc. | Heterozyklische derivate und ihre verwendung als therapeutische wirkstoffe |
| CA2580856A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| US7951805B2 (en) * | 2004-09-20 | 2011-05-31 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| US7767677B2 (en) | 2004-09-20 | 2010-08-03 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| EP1804799B1 (de) * | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren |
| CN101083986A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 双环杂环衍生物及其作为硬脂酰CoA去饱和酶(SCD)抑制剂的用途 |
| EP2316458A1 (de) * | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazin-Derivate zur Verhinderung menschlicher Stearoyl-coa-desaturas |
| EP2289510A1 (de) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate zur Behandlung von durch Stearoyl-Coa-Desaturase-Enzyme verursachten Krankheiten |
| EP1849465A4 (de) * | 2005-02-18 | 2008-12-24 | Takeda Pharmaceutical | Agens zur kontrolle der funktion des gpr34-rezeptors |
| EP2029138A1 (de) * | 2005-06-03 | 2009-03-04 | Xenon Pharmaceuticals Inc. | Aminothiazolderivate als humane stearoyl-coa desaturasehemmer |
| EP1845098A1 (de) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazinen, deren Herstellungverfahren und ihre Verwendung als GABA Rezeptor Liganden |
| KR101150581B1 (ko) * | 2007-07-26 | 2012-06-11 | 노파르티스 아게 | 유기 화합물 |
| TW201512201A (zh) * | 2013-03-14 | 2015-04-01 | Forum Pharmaceuticals Inc | 化合物的多晶型及鹽類 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3957766A (en) * | 1970-06-19 | 1976-05-18 | Boehringer Mannheim G.M.B.H. | Novel nitrofuran compounds and pharmaceutical compositions |
| US3878217A (en) | 1972-01-28 | 1975-04-15 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
| US4499088A (en) | 1983-01-04 | 1985-02-12 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| FR2601366B1 (fr) * | 1986-07-10 | 1988-11-25 | Andre Buzas | Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant. |
| JPS6413090A (en) * | 1987-07-07 | 1989-01-17 | Ube Industries | Xanthine derivative |
| GB8719368D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
| PH27291A (en) | 1989-01-31 | 1993-05-04 | Takeda Chemical Industries Ltd | Imidazolpyrimidazines their production and use |
| EP0440119A1 (de) | 1990-01-31 | 1991-08-07 | Takeda Chemical Industries, Ltd. | Imidazopyridazinverbindungen, ihre Herstellung und Verwendung |
| DE69106902T2 (de) | 1990-03-01 | 1995-07-06 | Takeda Chemical Industries Ltd | Imidazopyridazine, ihre Herstellung und Verwendung. |
| TW211013B (de) | 1991-12-27 | 1993-08-11 | Takeda Pharm Industry Co Ltd | |
| DE69322673T2 (de) | 1992-03-18 | 1999-05-06 | Takeda Chemical Industries, Ltd., Osaka | Imidazopyridazine als Antiasthmatika |
| LT3200B (en) | 1992-03-18 | 1995-03-27 | Takeda Chemical Industries Ltd | Triazolopyridazine methodfor production thereof and use |
| EP0620224B1 (de) | 1993-04-12 | 1998-07-15 | Takeda Chemical Industries, Ltd. | Triazolopyridazin-Derivate, ihre Herstellung und Verwendung |
| TW304878B (de) * | 1993-09-21 | 1997-05-11 | Takeda Pharm Industry Co Ltd | |
| CA2198019A1 (en) * | 1994-09-16 | 1996-03-21 | Takeda Chemical Industries, Ltd. | Triazolopyridazines process and intermediates for their preparation and their use as medicaments |
| JPH08337585A (ja) * | 1995-01-30 | 1996-12-24 | Takeda Chem Ind Ltd | セフェム化合物、その製造法および抗菌組成物 |
| AU4496896A (en) | 1995-01-30 | 1996-08-21 | Takeda Chemical Industries Ltd. | Cephem compounds, their production and use |
| US20010007867A1 (en) * | 1999-12-13 | 2001-07-12 | Yuhpyng L. Chen | Substituted 6,5-hetero-bicyclic derivatives |
| AU7079998A (en) * | 1997-04-25 | 1998-11-24 | Takeda Chemical Industries Ltd. | Condensed pyridazine derivatives, their production and use |
| GB9718254D0 (en) * | 1997-08-28 | 1997-11-05 | Merck Sharp & Dohme | Therapeutic agents |
| JPH11152275A (ja) * | 1997-09-16 | 1999-06-08 | Takeda Chem Ind Ltd | 含窒素縮合環化合物、その製造法および剤 |
| US6407116B1 (en) | 1997-09-16 | 2002-06-18 | Takeda Chemical Industries, Inc. | Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs |
-
1999
- 1999-10-20 AT AT99949322T patent/ATE256128T1/de not_active IP Right Cessation
- 1999-10-20 DE DE69913558T patent/DE69913558T2/de not_active Expired - Fee Related
- 1999-10-20 KR KR1020017005039A patent/KR20010087738A/ko not_active Abandoned
- 1999-10-20 US US09/807,806 patent/US6627630B1/en not_active Expired - Fee Related
- 1999-10-20 AU AU62273/99A patent/AU6227399A/en not_active Abandoned
- 1999-10-20 EP EP99949322A patent/EP1123936B1/de not_active Expired - Lifetime
- 1999-10-20 CA CA002348022A patent/CA2348022A1/en not_active Abandoned
- 1999-10-20 CN CN99814021A patent/CN1329614A/zh active Pending
- 1999-10-20 WO PCT/JP1999/005786 patent/WO2000023450A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69913558D1 (de) | 2004-01-22 |
| DE69913558T2 (de) | 2004-11-04 |
| US6627630B1 (en) | 2003-09-30 |
| KR20010087738A (ko) | 2001-09-21 |
| EP1123936A4 (de) | 2002-02-27 |
| CN1329614A (zh) | 2002-01-02 |
| EP1123936A1 (de) | 2001-08-16 |
| CA2348022A1 (en) | 2000-04-27 |
| WO2000023450A1 (en) | 2000-04-27 |
| AU6227399A (en) | 2000-05-08 |
| EP1123936B1 (de) | 2003-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |