ATE313535T1 - Pyrazinyl-piperazin-verbindungen, ihre anwendung und herstellung - Google Patents
Pyrazinyl-piperazin-verbindungen, ihre anwendung und herstellungInfo
- Publication number
- ATE313535T1 ATE313535T1 AT00931877T AT00931877T ATE313535T1 AT E313535 T1 ATE313535 T1 AT E313535T1 AT 00931877 T AT00931877 T AT 00931877T AT 00931877 T AT00931877 T AT 00931877T AT E313535 T1 ATE313535 T1 AT E313535T1
- Authority
- AT
- Austria
- Prior art keywords
- ring
- saturated
- disorders
- substituted
- ring members
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9901884A SE9901884D0 (sv) | 1999-05-21 | 1999-05-21 | Novel compounds their use and preparation |
| US13752799P | 1999-06-03 | 1999-06-03 | |
| PCT/SE2000/001017 WO2000076984A2 (en) | 1999-05-21 | 2000-05-19 | Novel compounds, their use and preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE313535T1 true ATE313535T1 (de) | 2006-01-15 |
Family
ID=26663577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00931877T ATE313535T1 (de) | 1999-05-21 | 2000-05-19 | Pyrazinyl-piperazin-verbindungen, ihre anwendung und herstellung |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1178973B1 (de) |
| KR (1) | KR100722090B1 (de) |
| CN (1) | CN1242995C (de) |
| AT (1) | ATE313535T1 (de) |
| AU (1) | AU777276C (de) |
| BR (1) | BR0010783A (de) |
| CA (1) | CA2374898C (de) |
| DE (1) | DE60024986T2 (de) |
| DK (1) | DK1178973T3 (de) |
| EA (1) | EA005820B1 (de) |
| ES (1) | ES2252004T3 (de) |
| HK (1) | HK1048311B (de) |
| IL (2) | IL146582A0 (de) |
| MX (1) | MXPA01011905A (de) |
| NO (1) | NO322220B1 (de) |
| NZ (1) | NZ515786A (de) |
| WO (1) | WO2000076984A2 (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
| PL360982A1 (en) | 2000-11-20 | 2004-09-20 | Biovitrum Ab | Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor |
| SE0004244D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
| GB0109103D0 (en) * | 2001-04-11 | 2001-05-30 | Pfizer Ltd | Novel compounds |
| US20030207857A1 (en) | 2001-04-11 | 2003-11-06 | Adam Mavis D. | Phenyl heterocyclyl ethers |
| US6825198B2 (en) | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| WO2003045313A2 (en) * | 2001-11-27 | 2003-06-05 | Merck & Co. Inc. | 2-aminoquinoline compounds |
| AU2003239128A1 (en) * | 2002-03-29 | 2003-10-20 | Schering Corporation | Stereoselective alkylation of chiral 2-methyl-4-protected piperazines |
| WO2003105850A1 (en) * | 2002-06-18 | 2003-12-24 | Abbott Laboratories | 2-aminoquinolines as melanin concentrating hormone receptor antagonists |
| US6989392B2 (en) | 2002-06-18 | 2006-01-24 | Abbott Laboratories | 2-Aminoquinolines as melanin concentrating hormone receptor antagonists |
| US7226925B2 (en) | 2002-06-19 | 2007-06-05 | Biovitrum Ab | Compounds, their use and preparation |
| CA2723494C (en) | 2002-06-19 | 2013-04-16 | Biovitrum Ab (Publ) | 2-methyl piperazine derivatives for treatment of serotonin-related disorders |
| CA2485537A1 (en) * | 2002-06-19 | 2003-12-31 | Biovitrum Ab | Novel compounds, their use and preparation |
| SI1529043T1 (sl) * | 2002-06-19 | 2006-12-31 | Biovitrum Ab | Postopek za pripravo 2-metil piperazinskih derivatov |
| SE0202287D0 (sv) * | 2002-07-19 | 2002-07-19 | Biovitrum Ab | New compounds |
| DE60311822T2 (de) * | 2002-07-19 | 2007-12-06 | Biovitrum Ab | Neue piperazinyl-pyrazinon-derivate zur behandlung von 5-ht2a rezeptor-bedingten erkrankungen |
| JP4960085B2 (ja) | 2003-03-19 | 2012-06-27 | エクセリクシス， インク． | Ｔｉｅ−２モジュレータと使用方法 |
| CL2004000826A1 (es) * | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
| WO2005037199A2 (en) | 2003-10-10 | 2005-04-28 | Bristol-Myers Squibb Company | Pyrazole derivatives as cannabinoid receptor modulators |
| US7423147B2 (en) | 2004-03-31 | 2008-09-09 | Janssen Pharmaceutical, N.V. | Pyridine compounds as histamine H3 modulators |
| JP5173190B2 (ja) | 2004-08-25 | 2013-03-27 | 武田薬品工業株式会社 | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
| GT200500317A (es) | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
| BRPI0518693A2 (pt) | 2004-11-29 | 2008-12-02 | Warner Lambert Co | pirazol [3,4-b]piridinas e indazàis terapÊuticos, bem como composiÇço farmacÊutica e uso dos mesmos |
| MX2007012082A (es) | 2005-03-31 | 2007-11-20 | Pfizer Prod Inc | Derivados de ciclopentapiridina y tetrahidroquinolina. |
| AR054849A1 (es) | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
| BRPI0709163A2 (pt) * | 2006-03-24 | 2011-06-28 | Wyeth Corp | tratamento da dor |
| TW200806298A (en) * | 2006-03-24 | 2008-02-01 | Wyeth Corp | Methods for modulating bladder function |
| EP2018863B9 (de) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Kondensierte, heterocyclische Verbindung und ihre Verwendung |
| NZ573028A (en) | 2006-05-30 | 2011-11-25 | Janssen Pharmaceutica Nv | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor |
| MX2010002772A (es) | 2007-09-21 | 2010-03-31 | Array Biopharma Inc | Derivados de piridin-2-il-amino-1,2,4-tiadiazol como activadores de glucocinasa para el tratamiento de diabetes mellitus. |
| US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
| UA103468C2 (ru) | 2007-11-20 | 2013-10-25 | Янссен Фармацевтика Н.В. | Соединения циклоалкилокси- и гетероциклоалкилоксипиридина как модуляторы гистаминового рецептора н3 |
| WO2011053696A1 (en) | 2009-10-30 | 2011-05-05 | Janssen Pharmaceutica Nv | Pyrazines as delta opioid receptor modulators |
| CN102686569B (zh) * | 2009-10-30 | 2014-11-26 | 詹森药业有限公司 | 用作阿片类受体调节剂的苯氧基取代嘧啶 |
| RU2568434C2 (ru) | 2009-10-30 | 2015-11-20 | Янссен Фармацевтика Нв | Пиримидиновые соединения для использования в качестве модуляторов дельта-опиоидных рецепторов |
| EP2510949A4 (de) | 2009-12-11 | 2013-11-13 | Astellas Pharma Inc | Therapeutikum für fibromyalgie |
| US20130267500A1 (en) | 2010-09-01 | 2013-10-10 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
| ES2564257T3 (es) | 2010-09-28 | 2016-03-21 | Bristol-Myers Squibb Company | Nuevos análogos de piperazina con grupos heteroarilo sustituidos como antivirales de amplio espectro de la gripe |
| US9718809B2 (en) | 2011-12-22 | 2017-08-01 | Kancera Ab | Bisarylsulfonamides useful in the treatment of inflammation and cancer |
| GB201312129D0 (en) * | 2013-07-05 | 2013-08-21 | Proximagen Ltd | Drug combination and its use in therapy |
| GB201312131D0 (en) * | 2013-07-05 | 2013-08-21 | Proximagen Ltd | Drug combination and its use in therapy |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| CN105348204B (zh) * | 2015-11-18 | 2018-09-14 | 乳源瑶族自治县大众药品贸易有限公司 | 1-杂环基-2-(杂芳基硫基)苯衍生物及其使用方法和用途 |
| CN105461635B (zh) * | 2015-11-18 | 2018-06-08 | 乳源瑶族自治县大众药品贸易有限公司 | 苯基哌嗪衍生物及其使用方法和用途 |
| CN108409729B (zh) * | 2017-02-09 | 2020-11-24 | 广东东阳光药业有限公司 | 苯基八氢-1H-吡啶并[1,2-a]吡嗪衍生物及其用途 |
| US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
| CN109111383B (zh) * | 2018-09-14 | 2020-11-24 | 广东东阳光药业有限公司 | 2-取代的二苯硫醚衍生物及其用途 |
| US11459340B2 (en) | 2018-09-18 | 2022-10-04 | Nikang Therapeutics, Inc. | Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors |
| CN114394887A (zh) * | 2022-01-28 | 2022-04-26 | 江苏锐鸣材料科技有限公司 | 一种苯基氧乙醇化合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI193974A (de) * | 1973-07-13 | 1975-01-14 | Merck & Co Inc | |
| GB9313913D0 (en) * | 1993-07-06 | 1993-08-18 | Smithkline Beecham Plc | Novel compounds |
| GB9420999D0 (en) * | 1994-10-18 | 1994-12-07 | Smithkline Beecham Plc | Novel compounds |
| WO1999058490A2 (en) * | 1998-05-08 | 1999-11-18 | Akzo Nobel N.V. | Novel aryl-hydro naphthalenal kanamines |
-
2000
- 2000-05-19 DE DE60024986T patent/DE60024986T2/de not_active Expired - Lifetime
- 2000-05-19 WO PCT/SE2000/001017 patent/WO2000076984A2/en not_active Application Discontinuation
- 2000-05-19 NZ NZ515786A patent/NZ515786A/en not_active IP Right Cessation
- 2000-05-19 CN CNB008102449A patent/CN1242995C/zh not_active Expired - Fee Related
- 2000-05-19 ES ES00931877T patent/ES2252004T3/es not_active Expired - Lifetime
- 2000-05-19 CA CA002374898A patent/CA2374898C/en not_active Expired - Fee Related
- 2000-05-19 EA EA200101223A patent/EA005820B1/ru not_active IP Right Cessation
- 2000-05-19 DK DK00931877T patent/DK1178973T3/da active
- 2000-05-19 AU AU49690/00A patent/AU777276C/en not_active Ceased
- 2000-05-19 IL IL14658200A patent/IL146582A0/xx unknown
- 2000-05-19 MX MXPA01011905A patent/MXPA01011905A/es active IP Right Grant
- 2000-05-19 BR BR0010783-2A patent/BR0010783A/pt not_active Application Discontinuation
- 2000-05-19 KR KR1020017014888A patent/KR100722090B1/ko not_active IP Right Cessation
- 2000-05-19 EP EP00931877A patent/EP1178973B1/de not_active Expired - Lifetime
- 2000-05-19 AT AT00931877T patent/ATE313535T1/de active
-
2001
- 2001-11-19 IL IL146582A patent/IL146582A/en not_active IP Right Cessation
- 2001-11-21 NO NO20015686A patent/NO322220B1/no not_active IP Right Cessation
-
2003
- 2003-01-15 HK HK03100371.6A patent/HK1048311B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0010783A (pt) | 2002-04-09 |
| WO2000076984A3 (en) | 2001-02-08 |
| EP1178973B1 (de) | 2005-12-21 |
| CA2374898C (en) | 2009-12-08 |
| MXPA01011905A (es) | 2004-03-19 |
| DE60024986T2 (de) | 2006-07-27 |
| NO20015686L (no) | 2002-01-15 |
| DK1178973T3 (da) | 2006-05-08 |
| NZ515786A (en) | 2004-01-30 |
| NO322220B1 (no) | 2006-08-28 |
| CA2374898A1 (en) | 2000-12-21 |
| ES2252004T3 (es) | 2006-05-16 |
| AU4969000A (en) | 2001-01-02 |
| AU777276C (en) | 2005-07-07 |
| CN1242995C (zh) | 2006-02-22 |
| HK1048311B (zh) | 2006-08-11 |
| HK1048311A1 (en) | 2003-03-28 |
| IL146582A (en) | 2010-04-29 |
| WO2000076984A8 (en) | 2001-07-19 |
| KR100722090B1 (ko) | 2007-05-25 |
| EP1178973A2 (de) | 2002-02-13 |
| DE60024986D1 (de) | 2006-01-26 |
| IL146582A0 (en) | 2002-07-25 |
| CN1360583A (zh) | 2002-07-24 |
| EA005820B1 (ru) | 2005-06-30 |
| EA200101223A1 (ru) | 2002-06-27 |
| AU777276B2 (en) | 2004-10-07 |
| NO20015686D0 (no) | 2001-11-21 |
| WO2000076984A2 (en) | 2000-12-21 |
| KR20020016795A (ko) | 2002-03-06 |
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