ATE211137T1 - Substituierte benzylthienylpiperazine, ihre anwendung als arzneimittel und verfahren für ihre herstellung - Google Patents
Substituierte benzylthienylpiperazine, ihre anwendung als arzneimittel und verfahren für ihre herstellungInfo
- Publication number
- ATE211137T1 ATE211137T1 AT96103772T AT96103772T ATE211137T1 AT E211137 T1 ATE211137 T1 AT E211137T1 AT 96103772 T AT96103772 T AT 96103772T AT 96103772 T AT96103772 T AT 96103772T AT E211137 T1 ATE211137 T1 AT E211137T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen
- alkylcarbonyl
- hydroxy
- integer
- benzylthienylpiperazines
- Prior art date
Links
- 229940126601 medicinal product Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- -1 benzothienylcarbonyl Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41381895A | 1995-03-17 | 1995-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE211137T1 true ATE211137T1 (de) | 2002-01-15 |
Family
ID=23638775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96103772T ATE211137T1 (de) | 1995-03-17 | 1996-03-11 | Substituierte benzylthienylpiperazine, ihre anwendung als arzneimittel und verfahren für ihre herstellung |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5801176A (de) |
| EP (1) | EP0732332B1 (de) |
| JP (1) | JPH093060A (de) |
| KR (1) | KR100402510B1 (de) |
| CN (1) | CN1082959C (de) |
| AT (1) | ATE211137T1 (de) |
| AU (1) | AU700077B2 (de) |
| CA (1) | CA2171695A1 (de) |
| CZ (1) | CZ80496A3 (de) |
| DE (1) | DE69618050T2 (de) |
| DK (1) | DK0732332T3 (de) |
| ES (1) | ES2170177T3 (de) |
| HU (1) | HUP9600665A3 (de) |
| IL (1) | IL117519A (de) |
| NO (1) | NO315652B1 (de) |
| NZ (1) | NZ286186A (de) |
| PL (1) | PL182310B1 (de) |
| PT (1) | PT732332E (de) |
| RO (1) | RO117453B1 (de) |
| RU (1) | RU2157371C2 (de) |
| SG (1) | SG54269A1 (de) |
| TW (1) | TW328957B (de) |
| ZA (1) | ZA962075B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703083A (en) * | 1996-04-15 | 1997-12-30 | Neurogen Corporation | N-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands |
| CA2341542A1 (en) | 1999-06-24 | 2000-12-28 | Toray Industries, Inc. | .alpha.1b-adrenergic receptor antagonists |
| EP1688412A3 (de) * | 2001-02-16 | 2006-08-16 | Aventis Pharmaceuticals, Inc. | Neue heterocyclische Amide-Derivate und ihre Verwendung als dopamine D3-Rezeptor-Liganden |
| IL157363A0 (en) * | 2001-02-16 | 2004-02-19 | Aventis Pharma Inc | Novel heterocyclic urea derivatives and their use as dopamine d3 receptor ligands |
| GB0117531D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands |
| US20040116522A1 (en) * | 2001-03-30 | 2004-06-17 | Yutaka Yamagata | Medicinal solutions |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| AR055203A1 (es) | 2005-08-31 | 2007-08-08 | Otsuka Pharma Co Ltd | Derivados de benzotiofeno con propiedades antipsicoticas |
| CN105985314A (zh) * | 2015-02-05 | 2016-10-05 | 苏州旺山旺水生物医药有限公司 | 布瑞哌唑类似物的制备方法 |
| PT4082616T (pt) * | 2019-12-24 | 2025-12-02 | Sumitomo Pharma Co Ltd | Derivado de amida ácida alifática |
| JP7655885B2 (ja) * | 2021-06-30 | 2025-04-02 | 住友ファーマ株式会社 | 脂肪族酸アミド誘導体を含有する医薬組成物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ209876A (en) * | 1983-10-17 | 1988-03-30 | Duphar Int Res | Piperazines and pharmaceutical compositions |
| DE3875073T2 (de) * | 1987-11-20 | 1993-03-11 | Hoechst Roussel Pharma | 3-(4(1-substituierte-4-piperazinyl)butyl)-4-thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel. |
| US5001130A (en) * | 1988-02-18 | 1991-03-19 | Bristol-Myers Company | Psychotropic heterobicycloalkylpiperazine derivatives |
| US4780466A (en) * | 1988-03-17 | 1988-10-25 | Hoechst-Roussel Pharmaceuticals, Inc. | Arylpiperazinylalkoxy derivatives of cyclic imides |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| US4968792A (en) * | 1989-09-25 | 1990-11-06 | American Home Products Corporation | Psychotropic benzisothiazole derivatives |
| US5143923B1 (en) * | 1991-04-29 | 1993-11-02 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
| RU2024520C1 (ru) * | 1991-10-08 | 1994-12-15 | Институт органической химии Уральского отделения РАН | 10-метокси-5- метил-6- (1',1'- диоксидо-2'- метахлорфенилазо -3'- гидрокси -4'-метоксибензо(в)тиофен- 7-ил) -5h-3,4,6,7- тетрагидрофуро [4.3.2-q] [3]бензазоцин, обладающий антидепрессивным действием |
| GB9202915D0 (en) * | 1992-02-12 | 1992-03-25 | Wellcome Found | Chemical compounds |
| US5240927A (en) * | 1992-05-19 | 1993-08-31 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzo[β]thiophen-3-yl piperazines as antipsychotic agents |
| GB9302622D0 (en) * | 1993-02-10 | 1993-03-24 | Wellcome Found | Heteroaromatic compounds |
| US5395835A (en) * | 1994-03-24 | 1995-03-07 | Warner-Lambert Company | Naphthalamides as central nervous system agents |
| GB9410031D0 (en) * | 1994-05-19 | 1994-07-06 | Merck Sharp & Dohme | Therapeutic agents |
-
1996
- 1996-03-11 EP EP96103772A patent/EP0732332B1/de not_active Expired - Lifetime
- 1996-03-11 DK DK96103772T patent/DK0732332T3/da active
- 1996-03-11 PT PT96103772T patent/PT732332E/pt unknown
- 1996-03-11 ES ES96103772T patent/ES2170177T3/es not_active Expired - Lifetime
- 1996-03-11 DE DE69618050T patent/DE69618050T2/de not_active Expired - Fee Related
- 1996-03-11 AT AT96103772T patent/ATE211137T1/de not_active IP Right Cessation
- 1996-03-12 SG SG1996006846A patent/SG54269A1/en unknown
- 1996-03-13 CA CA002171695A patent/CA2171695A1/en not_active Abandoned
- 1996-03-14 PL PL96313251A patent/PL182310B1/pl unknown
- 1996-03-14 ZA ZA9602075A patent/ZA962075B/xx unknown
- 1996-03-14 AU AU48113/96A patent/AU700077B2/en not_active Ceased
- 1996-03-14 HU HU9600665A patent/HUP9600665A3/hu unknown
- 1996-03-15 CZ CZ96804A patent/CZ80496A3/cs unknown
- 1996-03-15 JP JP8058707A patent/JPH093060A/ja not_active Abandoned
- 1996-03-15 RO RO96-00568A patent/RO117453B1/ro unknown
- 1996-03-15 CN CN96103608A patent/CN1082959C/zh not_active Expired - Fee Related
- 1996-03-15 NZ NZ286186A patent/NZ286186A/en unknown
- 1996-03-15 RU RU96104547/04A patent/RU2157371C2/ru not_active IP Right Cessation
- 1996-03-15 NO NO19961077A patent/NO315652B1/no not_active IP Right Cessation
- 1996-03-16 KR KR1019960007100A patent/KR100402510B1/ko not_active Expired - Fee Related
- 1996-03-17 IL IL11751996A patent/IL117519A/xx not_active IP Right Cessation
- 1996-05-15 TW TW085105712A patent/TW328957B/zh active
-
1997
- 1997-06-06 US US08/870,988 patent/US5801176A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL117519A0 (en) | 1996-07-23 |
| CA2171695A1 (en) | 1996-09-18 |
| HUP9600665A3 (en) | 1998-08-28 |
| HU9600665D0 (en) | 1996-05-28 |
| SG54269A1 (en) | 1998-11-16 |
| KR960034201A (ko) | 1996-10-22 |
| DK0732332T3 (da) | 2002-04-15 |
| NZ286186A (en) | 1997-07-27 |
| AU700077B2 (en) | 1998-12-17 |
| CZ80496A3 (en) | 1996-10-16 |
| HUP9600665A2 (en) | 1997-10-28 |
| CN1082959C (zh) | 2002-04-17 |
| PT732332E (pt) | 2002-06-28 |
| ZA962075B (en) | 1997-12-31 |
| KR100402510B1 (ko) | 2004-03-18 |
| PL313251A1 (en) | 1996-09-30 |
| EP0732332B1 (de) | 2001-12-19 |
| CN1139108A (zh) | 1997-01-01 |
| AU4811396A (en) | 1996-09-26 |
| NO315652B1 (no) | 2003-10-06 |
| IL117519A (en) | 2000-08-31 |
| US5801176A (en) | 1998-09-01 |
| PL182310B1 (pl) | 2001-12-31 |
| NO961077D0 (no) | 1996-03-15 |
| EP0732332A1 (de) | 1996-09-18 |
| DE69618050D1 (de) | 2002-01-31 |
| DE69618050T2 (de) | 2002-07-11 |
| ES2170177T3 (es) | 2002-08-01 |
| TW328957B (en) | 1998-04-01 |
| JPH093060A (ja) | 1997-01-07 |
| NO961077L (no) | 1996-09-18 |
| RO117453B1 (ro) | 2002-03-29 |
| RU2157371C2 (ru) | 2000-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |