IL117519A - Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising them - Google Patents

Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising them

Info

Publication number
IL117519A
IL117519A IL11751996A IL11751996A IL117519A IL 117519 A IL117519 A IL 117519A IL 11751996 A IL11751996 A IL 11751996A IL 11751996 A IL11751996 A IL 11751996A IL 117519 A IL117519 A IL 117519A
Authority
IL
Israel
Prior art keywords
hydrogen
pharmaceutical compositions
alkylcarbonyl
hydroxy
integer
Prior art date
Application number
IL11751996A
Other languages
English (en)
Other versions
IL117519A0 (en
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of IL117519A0 publication Critical patent/IL117519A0/xx
Publication of IL117519A publication Critical patent/IL117519A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL11751996A 1995-03-17 1996-03-17 Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising them IL117519A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41381895A 1995-03-17 1995-03-17

Publications (2)

Publication Number Publication Date
IL117519A0 IL117519A0 (en) 1996-07-23
IL117519A true IL117519A (en) 2000-08-31

Family

ID=23638775

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11751996A IL117519A (en) 1995-03-17 1996-03-17 Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising them

Country Status (23)

Country Link
US (1) US5801176A (xx)
EP (1) EP0732332B1 (xx)
JP (1) JPH093060A (xx)
KR (1) KR100402510B1 (xx)
CN (1) CN1082959C (xx)
AT (1) ATE211137T1 (xx)
AU (1) AU700077B2 (xx)
CA (1) CA2171695A1 (xx)
CZ (1) CZ80496A3 (xx)
DE (1) DE69618050T2 (xx)
DK (1) DK0732332T3 (xx)
ES (1) ES2170177T3 (xx)
HU (1) HUP9600665A3 (xx)
IL (1) IL117519A (xx)
NO (1) NO315652B1 (xx)
NZ (1) NZ286186A (xx)
PL (1) PL182310B1 (xx)
PT (1) PT732332E (xx)
RO (1) RO117453B1 (xx)
RU (1) RU2157371C2 (xx)
SG (1) SG54269A1 (xx)
TW (1) TW328957B (xx)
ZA (1) ZA962075B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703083A (en) * 1996-04-15 1997-12-30 Neurogen Corporation N-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands
WO2000078716A1 (fr) * 1999-06-24 2000-12-28 Toray Industries, Inc. ANTAGONISTES DU RECEPTEUR ADRENERGIQUE-α¿1B?
EP1361875A2 (en) * 2001-02-16 2003-11-19 Aventis Pharmaceuticals Inc. Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
IL157363A0 (en) * 2001-02-16 2004-02-19 Aventis Pharma Inc Novel heterocyclic urea derivatives and their use as dopamine d3 receptor ligands
GB0117531D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands
WO2002078669A1 (fr) * 2001-03-30 2002-10-10 Takeda Chemical Industries, Ltd. Solutions medicinales
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
TWI329641B (en) * 2005-08-31 2010-09-01 Otsuka Pharma Co Ltd (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
CN105985314A (zh) * 2015-02-05 2016-10-05 苏州旺山旺水生物医药有限公司 布瑞哌唑类似物的制备方法
EP4082616A4 (en) * 2019-12-24 2024-01-03 Sumitomo Pharma Co., Ltd. AMIDE DERIVATIVE OF ALIPHATIC ACID

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK169601B1 (da) * 1983-10-17 1994-12-19 Duphar Int Res Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse
EP0316723B1 (en) * 1987-11-20 1992-09-30 Hoechst-Roussel Pharmaceuticals Incorporated 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
US5240927A (en) * 1992-05-19 1993-08-31 Hoechst-Roussel Pharmaceuticals Incorporated Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
GB9302622D0 (en) * 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
US5395835A (en) * 1994-03-24 1995-03-07 Warner-Lambert Company Naphthalamides as central nervous system agents
GB9410031D0 (en) * 1994-05-19 1994-07-06 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
PL313251A1 (en) 1996-09-30
TW328957B (en) 1998-04-01
CN1082959C (zh) 2002-04-17
ES2170177T3 (es) 2002-08-01
KR960034201A (ko) 1996-10-22
HU9600665D0 (en) 1996-05-28
HUP9600665A3 (en) 1998-08-28
NO315652B1 (no) 2003-10-06
CN1139108A (zh) 1997-01-01
EP0732332B1 (en) 2001-12-19
HUP9600665A2 (en) 1997-10-28
US5801176A (en) 1998-09-01
EP0732332A1 (en) 1996-09-18
NZ286186A (en) 1997-07-27
SG54269A1 (en) 1998-11-16
NO961077L (no) 1996-09-18
NO961077D0 (no) 1996-03-15
AU700077B2 (en) 1998-12-17
DE69618050D1 (de) 2002-01-31
DE69618050T2 (de) 2002-07-11
AU4811396A (en) 1996-09-26
RO117453B1 (ro) 2002-03-29
ZA962075B (en) 1997-12-31
PL182310B1 (pl) 2001-12-31
PT732332E (pt) 2002-06-28
ATE211137T1 (de) 2002-01-15
JPH093060A (ja) 1997-01-07
CZ80496A3 (en) 1996-10-16
CA2171695A1 (en) 1996-09-18
IL117519A0 (en) 1996-07-23
KR100402510B1 (ko) 2004-03-18
DK0732332T3 (da) 2002-04-15
RU2157371C2 (ru) 2000-10-10

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees