EA200001165A1 - Производные тетрагидрохинолина в качестве антагонистов глицина - Google Patents

Производные тетрагидрохинолина в качестве антагонистов глицина

Info

Publication number
EA200001165A1
EA200001165A1 EA200001165A EA200001165A EA200001165A1 EA 200001165 A1 EA200001165 A1 EA 200001165A1 EA 200001165 A EA200001165 A EA 200001165A EA 200001165 A EA200001165 A EA 200001165A EA 200001165 A1 EA200001165 A1 EA 200001165A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
substituted
double bond
membered heteroaryl
alkyl
Prior art date
Application number
EA200001165A
Other languages
English (en)
Other versions
EA003276B1 (ru
Inventor
Романо Ди Фабио
Original Assignee
ГЛАКСО ВЭЛЛКАМ С.п.А
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9812410.0A external-priority patent/GB9812410D0/en
Priority claimed from GBGB9812408.4A external-priority patent/GB9812408D0/en
Application filed by ГЛАКСО ВЭЛЛКАМ С.п.А filed Critical ГЛАКСО ВЭЛЛКАМ С.п.А
Publication of EA200001165A1 publication Critical patent/EA200001165A1/ru
Publication of EA003276B1 publication Critical patent/EA003276B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Соединения формулы (I) или их соль или нетоксичные метаболически лабильные сложные эфиры, где Y представляет собой атом углерода, Z представляет собой группу CH, которая связана с группой Y посредством двойной связи, а X представляет собой CH, или Z представляет собой метилен или NR, а X представляет собой атом углерода, связанный с группой Y посредством двойной связи, A представляет собой Cалкиленовую цепь, которая может быть замещена одной или двумя группами, выбранными из Cалкила, возможно замещенного гидрокси, амино, Cалкиламино или Cдиалкиламино, или может быть замещена группой = O, R представляет собой атом галогена или Cалкильную группу, Rпредставляет собой атом водорода, атом галогена или Cалкильную группу, Rпредставляет собой возможно замещенный фенил, 5-членную гетероарильную группу, содержащую от 1 до 3 гетероатомов, выбранных из кислорода, серы и азота, или 6-членную гетероарильную группу, содержащую от 1 до 3 атомов азота, способы их получения и их применение в качестве антагонистов глицина.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001165A 1998-06-10 1999-06-08 Производные тетрагидрохинолина в качестве антагонистов глицина EA003276B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9812410.0A GB9812410D0 (en) 1998-06-10 1998-06-10 Heterocyclic derivatives
GBGB9812408.4A GB9812408D0 (en) 1998-06-10 1998-06-10 Heterocyclic compounds
PCT/EP1999/003936 WO1999064411A1 (en) 1998-06-10 1999-06-08 Tetrahydroquinoline derivatives as glycine antagonists

Publications (2)

Publication Number Publication Date
EA200001165A1 true EA200001165A1 (ru) 2001-06-25
EA003276B1 EA003276B1 (ru) 2003-04-24

Family

ID=26313826

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001165A EA003276B1 (ru) 1998-06-10 1999-06-08 Производные тетрагидрохинолина в качестве антагонистов глицина

Country Status (34)

Country Link
US (3) US6362199B1 (ru)
EP (1) EP1086093B1 (ru)
JP (1) JP2002517492A (ru)
KR (1) KR100586762B1 (ru)
CN (1) CN1173970C (ru)
AP (1) AP2000002008A0 (ru)
AR (1) AR018632A1 (ru)
AT (1) ATE301650T1 (ru)
AU (1) AU753867B2 (ru)
BG (1) BG105123A (ru)
BR (1) BR9911145A (ru)
CA (1) CA2334727C (ru)
CO (1) CO5080785A1 (ru)
CZ (1) CZ293605B6 (ru)
DE (1) DE69926632T2 (ru)
DK (1) DK1086093T3 (ru)
EA (1) EA003276B1 (ru)
EE (1) EE200000733A (ru)
ES (1) ES2249010T3 (ru)
HK (1) HK1034079A1 (ru)
HR (1) HRP20000845A2 (ru)
HU (1) HUP0102767A3 (ru)
ID (1) ID27845A (ru)
IL (2) IL140062A0 (ru)
IS (1) IS5746A (ru)
MY (1) MY125037A (ru)
NO (1) NO321904B1 (ru)
NZ (1) NZ508638A (ru)
OA (1) OA11564A (ru)
PE (1) PE20000724A1 (ru)
PL (1) PL197160B1 (ru)
TR (1) TR200003652T2 (ru)
TW (1) TWI229079B (ru)
WO (1) WO1999064411A1 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
GB9929037D0 (en) * 1999-12-08 2000-02-02 Glaxo Wellcome Spa Heterocyclic derivatives
DE10000311A1 (de) 2000-01-05 2001-07-12 Gruenenthal Gmbh Aminomethyl-Phonyl-Cyclohexanonderivate
DE10005302A1 (de) * 2000-02-07 2002-01-17 Gruenenthal Gmbh Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
DE10137488A1 (de) * 2001-08-03 2003-02-20 Gruenenthal Gmbh Salze substituierter 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
DE10137487A1 (de) 2001-08-03 2003-03-27 Gruenenthal Gmbh Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate
JP2006508077A (ja) * 2002-10-04 2006-03-09 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 炎症疾患を治療するためのｐｇｄ２レセプタアンタゴニスト
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
GB0327912D0 (en) * 2003-12-02 2004-01-07 Glaxo Group Ltd Medicament
CA2598133A1 (en) * 2005-02-24 2006-08-31 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2024516C1 (ru) * 1989-02-02 1994-12-15 Яманути Фармасьютикал Ко., Лтд. Способ получения производного тетрагидробензимидазола или его фармацевтически приемлемой соли
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5231102A (en) * 1989-03-08 1993-07-27 Merck Sharp & Dohme, Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
IL93610A0 (en) * 1989-03-08 1990-12-23 Merck Sharp & Dohme Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them
US5529999A (en) 1994-03-04 1996-06-25 Eli Lilly And Company Antitumor compositions and methods of treatment
CA2232509A1 (en) 1995-09-29 1997-04-10 Glaxo Wellcome Spa Tetrahydroquinolines as nmda antagonists
GB9617305D0 (en) * 1996-08-17 1996-09-25 Glaxo Wellcome Spa Heterocyclic compounds
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives

Also Published As

Publication number Publication date
HK1034079A1 (en) 2001-10-12
JP2002517492A (ja) 2002-06-18
US6413985B1 (en) 2002-07-02
KR100586762B1 (ko) 2006-06-08
NO20006227D0 (no) 2000-12-07
CA2334727C (en) 2009-08-04
CN1311785A (zh) 2001-09-05
IL140062A0 (en) 2002-02-10
DE69926632T2 (de) 2006-01-19
ID27845A (id) 2001-04-26
DE69926632D1 (de) 2005-09-15
ATE301650T1 (de) 2005-08-15
BG105123A (en) 2001-11-30
EE200000733A (et) 2002-06-17
PL197160B1 (pl) 2008-03-31
TR200003652T2 (tr) 2001-04-20
ES2249010T3 (es) 2006-03-16
IL140062A (en) 2007-05-15
AU753867B2 (en) 2002-10-31
EP1086093B1 (en) 2005-08-10
AP2000002008A0 (en) 2000-12-31
HUP0102767A3 (en) 2003-01-28
OA11564A (en) 2004-05-24
NO321904B1 (no) 2006-07-17
CN1173970C (zh) 2004-11-03
CZ20004587A3 (en) 2001-05-16
MY125037A (en) 2006-07-31
TWI229079B (en) 2005-03-11
EA003276B1 (ru) 2003-04-24
US6495566B2 (en) 2002-12-17
CO5080785A1 (es) 2001-09-25
CZ293605B6 (cs) 2004-06-16
DK1086093T3 (da) 2005-11-28
KR20010052722A (ko) 2001-06-25
PL344694A1 (en) 2001-11-19
IS5746A (is) 2000-11-30
WO1999064411A1 (en) 1999-12-16
NZ508638A (en) 2003-08-29
AR018632A1 (es) 2001-11-28
CA2334727A1 (en) 1999-12-16
HUP0102767A2 (hu) 2001-12-28
NO20006227L (no) 2001-02-08
AU4509299A (en) 1999-12-30
BR9911145A (pt) 2001-03-06
EP1086093A1 (en) 2001-03-28
HRP20000845A2 (en) 2001-10-31
US20020052391A1 (en) 2002-05-02
PE20000724A1 (es) 2000-08-17
US20020169186A1 (en) 2002-11-14
US6362199B1 (en) 2002-03-26

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU