EA199900678A1 - Производные амида гетероарил-гексановой кислоты, их получение и их применение в качестве селективных ингибиторов связывания mip-1-альфа с его рецептором ccr1 - Google Patents

Производные амида гетероарил-гексановой кислоты, их получение и их применение в качестве селективных ингибиторов связывания mip-1-альфа с его рецептором ccr1

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EA199900678A1
EA199900678A1 EA199900678A EA199900678A EA199900678A1 EA 199900678 A1 EA199900678 A1 EA 199900678A1 EA 199900678 A EA199900678 A EA 199900678A EA 199900678 A EA199900678 A EA 199900678A EA 199900678 A1 EA199900678 A1 EA 199900678A1
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Eurasian Patent Office
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alkyl
heteroaryl
heteroarryl
receiving
application
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EA199900678A
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EA002146B1 (ru
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Мэттью Фрэнк Браун
Джон Чарлз Кэт
Кристофер Стенли Посс
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Пфайзер Инк.
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Publication of EA199900678A1 publication Critical patent/EA199900678A1/ru
Publication of EA002146B1 publication Critical patent/EA002146B1/ru

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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  • Pyridine Compounds (AREA)

Abstract

Соединения формулы (I), где Rпредставляет собой возможно замещенный (C-C)гетероарил; Rпредставляет собой возможно замещенный фенил-(CH)-, нафтил-(CH)-, (C-C)циклоалкил-(CH)-, (C-C)алкил или (C-C)гетероарил-(CH)-, m является целым числом от нуля до четырех; Rпредставляет собой водород или возможно замещенный (C-C)алкил, (C-C)циклоалкил-(CH)-, (C-C)гетероциклоалкил-(CH)-, (C-C)гетероарил-(CH)- или арил-(CH)-, n является целым числом от нуля до шести; или Rи атом углерода, к которому он присоединен, образуют возможно замещенное и/или конденсированное 5-7-членное карбоциклическое кольцо; Rпредставляет собой водород, (C-C)алкил, гидрокси, (C-C)алкокси, гидрокси(C-C)алкил, (C-C)алкоксиCO, (C-C)циклоалкил-(CH)- или возможно замещенный (C-C)гетероциклоалкил-(CH)-, (C-C)гетероарил-(CH)-, фенил-(CH)- или нафтил-(CH)-, p является целым числом от нуля до четырех; или Rи Rвместе с атомом азота, к которому они присоединены, образуют возможно замещенную (C-C)гетероциклоалкильную группу; Rявляется водородом, (C-C)алкилом или амино. Представленные соединения являются сильнодействующими и селективными ингибиторами связывания MIP-1-альфа с его рецептором CCR1 и, следовательно, они пригодны для лечения воспаления и других иммунных расстройств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900678A 1997-02-26 1998-02-05 Производные амида гетероарил-гексановой кислоты, их получение и их применение в качестве селективных ингибиторов связывания mip-1-альфа с его рецептором ccr1 EA002146B1 (ru)

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PCT/US1998/001568 WO1998038167A1 (en) 1997-02-26 1998-02-05 Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor

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