EA199800882A1 - Производные замешенных индазолов, их применение в качестве ингибиторов фосфодиэстеразы (фдэ) iv и получение фактора некроза опухолей (фно) - Google Patents

Производные замешенных индазолов, их применение в качестве ингибиторов фосфодиэстеразы (фдэ) iv и получение фактора некроза опухолей (фно)

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Publication number
EA199800882A1
EA199800882A1 EA199800882A EA199800882A EA199800882A1 EA 199800882 A1 EA199800882 A1 EA 199800882A1 EA 199800882 A EA199800882 A EA 199800882A EA 199800882 A EA199800882 A EA 199800882A EA 199800882 A1 EA199800882 A1 EA 199800882A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pde
tnf
necrosis factor
formula
photophodiesterrase
Prior art date
Application number
EA199800882A
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English (en)
Other versions
EA002272B1 (ru
Inventor
Энтони Марфат
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Пфайзер Инк
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Publication date
Application filed by Пфайзер Инк filed Critical Пфайзер Инк
Publication of EA199800882A1 publication Critical patent/EA199800882A1/ru
Publication of EA002272B1 publication Critical patent/EA002272B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к соединениям формулы (I) и их фармацевтически приемлемым солям, где R и Rтакие, как определены здесь, Rвыбран из группы, состоящей из (Iа), (Iб, (Iв) и (Iг). Кроме того, изобретение относится к промежуточным соединениям для получения соединений формулы (I) и к фармацевтическим композициям, содержащим соединения формулы (I) или их фармацевтически приемлемые соли, и к способам применения соединений формулы (I) или их фармацевтически приемлемых солей для ингибирования фосфодиэстеразы (ФДЭ) типа IV или продукции фактора некроза опухолей (ФНО) у млекопитающих.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800882A 1996-05-03 1997-04-01 Производные замещенных индазолов, их применение в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и продукции фактора некроза опухолей (фно) EA002272B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1686196P 1996-05-03 1996-05-03
PCT/IB1997/000323 WO1997042174A1 (en) 1996-05-03 1997-04-01 Substituted indazole derivatives and their use as inhibitors phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)

Publications (2)

Publication Number Publication Date
EA199800882A1 true EA199800882A1 (ru) 1999-06-24
EA002272B1 EA002272B1 (ru) 2002-02-28

Family

ID=21779401

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800882A EA002272B1 (ru) 1996-05-03 1997-04-01 Производные замещенных индазолов, их применение в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и продукции фактора некроза опухолей (фно)

Country Status (42)

Country Link
US (2) US6211222B1 (ru)
EP (1) EP0912521B1 (ru)
JP (1) JP3148254B2 (ru)
KR (1) KR100339935B1 (ru)
CN (2) CN1112359C (ru)
AP (4) AP1147A (ru)
AR (1) AR006906A1 (ru)
AT (1) ATE292626T1 (ru)
AU (1) AU725576B2 (ru)
BG (1) BG64211B1 (ru)
BR (1) BR9709051A (ru)
CA (2) CA2389918A1 (ru)
CO (1) CO4650038A1 (ru)
CZ (1) CZ292825B6 (ru)
DE (1) DE69732966T2 (ru)
DZ (1) DZ2217A1 (ru)
EA (1) EA002272B1 (ru)
ES (1) ES2238079T3 (ru)
GT (1) GT199700043A (ru)
HK (1) HK1019443A1 (ru)
HN (1) HN1997000046A (ru)
HR (1) HRP970227B1 (ru)
HU (1) HUP9902459A3 (ru)
ID (1) ID16856A (ru)
IL (2) IL126547A (ru)
IS (1) IS4871A (ru)
MA (1) MA24158A1 (ru)
MY (1) MY132499A (ru)
NO (1) NO312959B1 (ru)
NZ (1) NZ332240A (ru)
OA (1) OA10904A (ru)
PE (1) PE64598A1 (ru)
PL (1) PL329836A1 (ru)
SK (1) SK148298A3 (ru)
TN (1) TNSN97070A1 (ru)
TR (1) TR199802202T2 (ru)
TW (1) TW449585B (ru)
UA (1) UA65536C2 (ru)
UY (1) UY24532A1 (ru)
WO (1) WO1997042174A1 (ru)
YU (1) YU16397A (ru)
ZA (1) ZA973804B (ru)

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EA200000488A1 (ru) * 1997-11-04 2000-10-30 Пфайзер Продактс Инк. Замена катехина на биоизостеру индазола в терапевтически активных соединениях
CA2309175A1 (en) * 1997-11-04 1999-05-14 Pfizer Products Inc. Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
IL132407A0 (en) * 1998-10-21 2001-03-19 Pfizer Prod Inc Method for treating congestive heart failure
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Also Published As

Publication number Publication date
TNSN97070A1 (fr) 2005-03-15
GT199700043A (es) 1998-10-02
OA10904A (en) 2001-10-11
AU1937397A (en) 1997-11-26
IS4871A (is) 1998-10-16
PL329836A1 (en) 1999-04-12
DZ2217A1 (fr) 2002-12-03
HN1997000046A (es) 1997-06-26
CZ349298A3 (cs) 1999-09-15
JP3148254B2 (ja) 2001-03-19
AP0102304A0 (en) 1997-11-03
MA24158A1 (fr) 1997-12-31
IL126547A0 (en) 1999-08-17
HK1019443A1 (en) 2000-02-11
CA2252982A1 (en) 1997-11-13
PE64598A1 (es) 1998-10-26
BG64211B1 (bg) 2004-05-31
ZA973804B (en) 1998-11-02
CN1217714A (zh) 1999-05-26
NZ332240A (en) 2000-07-28
AR006906A1 (es) 1999-09-29
IL126547A (en) 2003-03-12
CN1112359C (zh) 2003-06-25
EP0912521A1 (en) 1999-05-06
AP2001002294A0 (en) 2001-12-31
ATE292626T1 (de) 2005-04-15
SK148298A3 (en) 2000-02-14
UY24532A1 (es) 2000-09-29
CA2252982C (en) 2002-10-08
AP1146A (en) 2003-02-25
CA2389918A1 (en) 1997-11-13
HUP9902459A2 (hu) 1999-11-29
KR100339935B1 (ko) 2002-07-18
NO312959B1 (no) 2002-07-22
TR199802202T2 (xx) 1999-02-22
TW449585B (en) 2001-08-11
EA002272B1 (ru) 2002-02-28
JPH11508284A (ja) 1999-07-21
MY132499A (en) 2007-10-31
KR20000010751A (ko) 2000-02-25
CO4650038A1 (es) 1998-09-03
DE69732966D1 (de) 2005-05-12
ID16856A (id) 1997-11-13
HRP970227A2 (en) 2000-12-31
IL152083A0 (en) 2003-05-29
AP9700975A0 (en) 1997-07-31
ES2238079T3 (es) 2005-08-16
AP1147A (en) 2003-02-25
US6211222B1 (en) 2001-04-03
US6127398A (en) 2000-10-03
NO985095D0 (no) 1998-11-02
CN1422849A (zh) 2003-06-11
BG102946A (en) 1999-11-30
DE69732966T2 (de) 2005-09-08
EP0912521B1 (en) 2005-04-06
AP2001002304A0 (en) 2001-12-31
HRP970227B1 (en) 2002-06-30
CZ292825B6 (cs) 2003-12-17
NO985095L (no) 1998-12-29
UA65536C2 (en) 2004-04-15
BR9709051A (pt) 1999-08-03
YU16397A (sh) 1999-12-27
HUP9902459A3 (en) 2001-10-29
WO1997042174A1 (en) 1997-11-13
AU725576B2 (en) 2000-10-12

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