YU16397A - Supstituisani derivati indazola i srodna jedinjenja - Google Patents

Supstituisani derivati indazola i srodna jedinjenja

Info

Publication number
YU16397A
YU16397A YU16397A YU16397A YU16397A YU 16397 A YU16397 A YU 16397A YU 16397 A YU16397 A YU 16397A YU 16397 A YU16397 A YU 16397A YU 16397 A YU16397 A YU 16397A
Authority
YU
Yugoslavia
Prior art keywords
compounds
formula
compounps
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
YU16397A
Other languages
English (en)
Inventor
Anthony Marfat
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU16397A publication Critical patent/YU16397A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Pronalazak se odnosi na jedinjenja formule I i na njihove farmaceutski prihvatljive soli, pri čemu je R cikloheksil, ciklopentil, metilenciklopropil, izopropil, fenil ili 4-fluorofenil, R1 je etil opciono supstituisan sa do tri fluora i R2 je grupa izabrana od gde isprekidana linija predstavlja jednostruku ili dvostruku vezu. Pronalazak se dalje odnosi na intermedijere za dobijanje jedinjenja formule I, na farmaceutske kompozicije koje ih sadrže, i na metode korišćenja jedinjenja formule I ili njihovih farmaceutski prihvatljivih soli za inhibiciju fosfodiesteraze (PDE) tipa IV ili stvaranja tumor nekrozis faktora (TNF) kod sisara.
YU16397A 1996-05-03 1997-04-29 Supstituisani derivati indazola i srodna jedinjenja YU16397A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1686196P 1996-05-03 1996-05-03

Publications (1)

Publication Number Publication Date
YU16397A true YU16397A (sh) 1999-12-27

Family

ID=21779401

Family Applications (1)

Application Number Title Priority Date Filing Date
YU16397A YU16397A (sh) 1996-05-03 1997-04-29 Supstituisani derivati indazola i srodna jedinjenja

Country Status (42)

Country Link
US (2) US6211222B1 (sh)
EP (1) EP0912521B1 (sh)
JP (1) JP3148254B2 (sh)
KR (1) KR100339935B1 (sh)
CN (2) CN1112359C (sh)
AP (4) AP1147A (sh)
AR (1) AR006906A1 (sh)
AT (1) ATE292626T1 (sh)
AU (1) AU725576B2 (sh)
BG (1) BG64211B1 (sh)
BR (1) BR9709051A (sh)
CA (2) CA2252982C (sh)
CO (1) CO4650038A1 (sh)
CZ (1) CZ292825B6 (sh)
DE (1) DE69732966T2 (sh)
DZ (1) DZ2217A1 (sh)
EA (1) EA002272B1 (sh)
ES (1) ES2238079T3 (sh)
GT (1) GT199700043A (sh)
HK (1) HK1019443A1 (sh)
HN (1) HN1997000046A (sh)
HR (1) HRP970227B1 (sh)
HU (1) HUP9902459A3 (sh)
ID (1) ID16856A (sh)
IL (2) IL126547A (sh)
IS (1) IS4871A (sh)
MA (1) MA24158A1 (sh)
MY (1) MY132499A (sh)
NO (1) NO312959B1 (sh)
NZ (1) NZ332240A (sh)
OA (1) OA10904A (sh)
PE (1) PE64598A1 (sh)
PL (1) PL329836A1 (sh)
SK (1) SK148298A3 (sh)
TN (1) TNSN97070A1 (sh)
TR (1) TR199802202T2 (sh)
TW (1) TW449585B (sh)
UA (1) UA65536C2 (sh)
UY (1) UY24532A1 (sh)
WO (1) WO1997042174A1 (sh)
YU (1) YU16397A (sh)
ZA (1) ZA973804B (sh)

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AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
US6005118A (en) * 1996-05-03 1999-12-21 Caron; Stephane Methods of preparing 4-cyano-4 (substituted indazole) cyclohexane-carboxylic acids useful as PDE4 inhibitors
CA2258728C (en) * 1996-06-19 2011-09-27 Rhone Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
DK0983249T3 (da) * 1997-05-08 2002-07-08 Pfizer Prod Inc Fremgangsmåder og mellemprodukter til fremstilling af substituerede indazolderivater
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
SK6252000A3 (en) * 1997-11-04 2001-11-06 Pfizer Prod Inc Indazole bioisostere replacement of catechol in therapeutically active compounds
HUP0100330A3 (en) * 1997-11-04 2002-03-28 Pfizer Prod Inc Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors, compositions containing them and their use
IL132407A0 (en) * 1998-10-21 2001-03-19 Pfizer Prod Inc Method for treating congestive heart failure
JP2000198734A (ja) * 1998-12-30 2000-07-18 Pfizer Inc 胃運動性減弱および関連疾患の治療のための運動性増強薬
WO2001047915A1 (en) * 1999-12-23 2001-07-05 Icos Corporation Cyclic amp-specific phosphodiesterase inhibitors
US6362213B1 (en) 1999-12-23 2002-03-26 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
US7211594B2 (en) * 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
US6953774B2 (en) 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
WO2003051344A1 (en) 2001-12-14 2003-06-26 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation_using a non-polypeptide camp level modulator
US20040034084A1 (en) * 2002-05-24 2004-02-19 Celgene Corporation Methods for using JNK inhibitors for treating or preventing disease-related wasting
US7196082B2 (en) * 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US20050019366A1 (en) * 2002-12-31 2005-01-27 Zeldis Jerome B. Drug-coated stents and methods of use therefor
DE10318610A1 (de) 2003-04-24 2004-11-11 Elbion Ag 7-Azaindole und deren Verwendung als Therapeutika
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
US20070004777A1 (en) * 2005-03-23 2007-01-04 Bhagwat Shripad S Methods for treating or preventing acute myelogenous leukemia
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US8277809B2 (en) * 2006-04-21 2012-10-02 Centocor, Inc. CXCL13 antagonists and their use for the treatment of inflammatory diseases
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
KR20200104291A (ko) 2017-11-06 2020-09-03 랩트 테라퓨틱스, 인크. 항암제

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Also Published As

Publication number Publication date
BG102946A (en) 1999-11-30
EA199800882A1 (ru) 1999-06-24
EP0912521B1 (en) 2005-04-06
GT199700043A (es) 1998-10-02
JP3148254B2 (ja) 2001-03-19
US6127398A (en) 2000-10-03
DE69732966T2 (de) 2005-09-08
ID16856A (id) 1997-11-13
CA2252982A1 (en) 1997-11-13
SK148298A3 (en) 2000-02-14
AP1146A (en) 2003-02-25
IL152083A0 (en) 2003-05-29
BR9709051A (pt) 1999-08-03
PL329836A1 (en) 1999-04-12
EP0912521A1 (en) 1999-05-06
AP1147A (en) 2003-02-25
HK1019443A1 (en) 2000-02-11
HUP9902459A2 (hu) 1999-11-29
NO312959B1 (no) 2002-07-22
CZ349298A3 (cs) 1999-09-15
AP0102304A0 (en) 1997-11-03
IL126547A0 (en) 1999-08-17
NO985095L (no) 1998-12-29
TNSN97070A1 (fr) 2005-03-15
JPH11508284A (ja) 1999-07-21
AP2001002294A0 (en) 2001-12-31
CZ292825B6 (cs) 2003-12-17
AU725576B2 (en) 2000-10-12
UA65536C2 (en) 2004-04-15
AU1937397A (en) 1997-11-26
MA24158A1 (fr) 1997-12-31
US6211222B1 (en) 2001-04-03
EA002272B1 (ru) 2002-02-28
ATE292626T1 (de) 2005-04-15
CA2389918A1 (en) 1997-11-13
KR100339935B1 (ko) 2002-07-18
DE69732966D1 (de) 2005-05-12
HUP9902459A3 (en) 2001-10-29
ZA973804B (en) 1998-11-02
WO1997042174A1 (en) 1997-11-13
AP2001002304A0 (en) 2001-12-31
NO985095D0 (no) 1998-11-02
NZ332240A (en) 2000-07-28
TW449585B (en) 2001-08-11
CO4650038A1 (es) 1998-09-03
ES2238079T3 (es) 2005-08-16
IS4871A (is) 1998-10-16
MY132499A (en) 2007-10-31
HRP970227B1 (en) 2002-06-30
HN1997000046A (es) 1997-06-26
UY24532A1 (es) 2000-09-29
HRP970227A2 (en) 2000-12-31
IL126547A (en) 2003-03-12
BG64211B1 (bg) 2004-05-31
KR20000010751A (ko) 2000-02-25
CA2252982C (en) 2002-10-08
CN1112359C (zh) 2003-06-25
AP9700975A0 (en) 1997-07-31
CN1217714A (zh) 1999-05-26
DZ2217A1 (fr) 2002-12-03
OA10904A (en) 2001-10-11
PE64598A1 (es) 1998-10-26
AR006906A1 (es) 1999-09-29
CN1422849A (zh) 2003-06-11
TR199802202T2 (xx) 1999-02-22

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