UY24532A1 - Derivados del indazol sustituidos y compuestos relacionados - Google Patents

Derivados del indazol sustituidos y compuestos relacionados

Info

Publication number
UY24532A1
UY24532A1 UY24532A UY24532A UY24532A1 UY 24532 A1 UY24532 A1 UY 24532A1 UY 24532 A UY24532 A UY 24532A UY 24532 A UY24532 A UY 24532A UY 24532 A1 UY24532 A1 UY 24532A1
Authority
UY
Uruguay
Prior art keywords
alkyl
formula
compounds
tetrazolyl
isoxazolyl
Prior art date
Application number
UY24532A
Other languages
English (en)
Inventor
Marfat Anthony
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY24532A1 publication Critical patent/UY24532A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a derivados de indazol de la fórmula (I), en la que: R es H, alquilo, -(CH2)n(cicloalquilo), donde n es 0 a 2, (alcoxi)alquilo, alquenilo, -(CH2)n(heterociclilo), donde n es 0 a 2 ó -(Z')b(Z'')c(arilo), donde b y c son independientemente 0 ó 1, Z' es alquileno o alquenileno y Z'' es O, S, SO2; R1 es H, alquilo, alquenilo, fenilo, cicloalquilo; R2 se seleccciona entre el grupo de sustituyentes que se presentan en fig.2; en el que las líneas discontinuas en las fórmulas (Ia) y (Ib) representan un enlace simple o doble; m es 0 a 4; R3 es H, halógeno, ciano, alquilo, ciclopropilo; R4 es H, COOH, CN, , tetrazolilo, tiazolilo, imidazolilo, pirazolilo, oxazolilo, triazolilo, isoxazolilo; R5 es H, alquilo, CH2OH, CN, C(O)H, COOH, CONH2 o NH2; R6 es metilo, etilo; R7 es OH, SH, SO2NH2, tetrazolilo, tiazolilo, imidazolilo, oxazolilo, isoxazolilo; y a las sales farmacéuticamente aceptables de los mismos. La invención además, se refiere a los productos intermedios para la preparación de los compuestos de fórmula (I), a las composiciones farmacéuticas que los contienen y a los procedimientos de uso, de los compuestos de fórmula (I) o de las sales farmacéuticamente aceptables de los mismos, para la inhibición de la fosfodiesterasa (PDE) tipo IV y de la producción de factor de necrosis tumoral (TNF) en un mamífero y como tales son útiles en el tratamiento del asma, bronquitis, artritis. Ej. no limitante 1-(1-ciclopentil-3-etil-1H-indazol-6-il)-4-oxo-ciclohexanocarbonitrilo
UY24532A 1996-05-03 1997-04-28 Derivados del indazol sustituidos y compuestos relacionados UY24532A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1686196P 1996-05-03 1996-05-03

Publications (1)

Publication Number Publication Date
UY24532A1 true UY24532A1 (es) 2000-09-29

Family

ID=21779401

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24532A UY24532A1 (es) 1996-05-03 1997-04-28 Derivados del indazol sustituidos y compuestos relacionados

Country Status (42)

Country Link
US (2) US6211222B1 (es)
EP (1) EP0912521B1 (es)
JP (1) JP3148254B2 (es)
KR (1) KR100339935B1 (es)
CN (2) CN1112359C (es)
AP (4) AP1147A (es)
AR (1) AR006906A1 (es)
AT (1) ATE292626T1 (es)
AU (1) AU725576B2 (es)
BG (1) BG64211B1 (es)
BR (1) BR9709051A (es)
CA (2) CA2252982C (es)
CO (1) CO4650038A1 (es)
CZ (1) CZ292825B6 (es)
DE (1) DE69732966T2 (es)
DZ (1) DZ2217A1 (es)
EA (1) EA002272B1 (es)
ES (1) ES2238079T3 (es)
GT (1) GT199700043A (es)
HK (1) HK1019443A1 (es)
HN (1) HN1997000046A (es)
HR (1) HRP970227B1 (es)
HU (1) HUP9902459A3 (es)
ID (1) ID16856A (es)
IL (2) IL126547A (es)
IS (1) IS4871A (es)
MA (1) MA24158A1 (es)
MY (1) MY132499A (es)
NO (1) NO312959B1 (es)
NZ (1) NZ332240A (es)
OA (1) OA10904A (es)
PE (1) PE64598A1 (es)
PL (1) PL329836A1 (es)
SK (1) SK148298A3 (es)
TN (1) TNSN97070A1 (es)
TR (1) TR199802202T2 (es)
TW (1) TW449585B (es)
UA (1) UA65536C2 (es)
UY (1) UY24532A1 (es)
WO (1) WO1997042174A1 (es)
YU (1) YU16397A (es)
ZA (1) ZA973804B (es)

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CA2258728C (en) 1996-06-19 2011-09-27 Rhone Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
DK0983249T3 (da) * 1997-05-08 2002-07-08 Pfizer Prod Inc Fremgangsmåder og mellemprodukter til fremstilling af substituerede indazolderivater
CA2309175A1 (en) * 1997-11-04 1999-05-14 Pfizer Products Inc. Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
JP2001521926A (ja) * 1997-11-04 2001-11-13 ファイザー・プロダクツ・インク 治療上活性の化合物におけるカテコールのインダゾール生物学的等価物置換
IL132407A0 (en) * 1998-10-21 2001-03-19 Pfizer Prod Inc Method for treating congestive heart failure
JP2000198734A (ja) * 1998-12-30 2000-07-18 Pfizer Inc 胃運動性減弱および関連疾患の治療のための運動性増強薬
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US6362213B1 (en) 1999-12-23 2002-03-26 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US7211594B2 (en) * 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
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US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
US20070004777A1 (en) * 2005-03-23 2007-01-04 Bhagwat Shripad S Methods for treating or preventing acute myelogenous leukemia
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JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
BRPI0710636A2 (pt) * 2006-04-21 2011-08-23 Centocor Inc antagonistas de cxcl 31 e o uso dos mesmos para o tratamento de doenças inflamatórias
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
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EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
KR20200104291A (ko) 2017-11-06 2020-09-03 랩트 테라퓨틱스, 인크. 항암제

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Also Published As

Publication number Publication date
OA10904A (en) 2001-10-11
HN1997000046A (es) 1997-06-26
SK148298A3 (en) 2000-02-14
NO312959B1 (no) 2002-07-22
MY132499A (en) 2007-10-31
AP0102304A0 (en) 1997-11-03
NO985095D0 (no) 1998-11-02
AP1146A (en) 2003-02-25
HRP970227A2 (en) 2000-12-31
EA199800882A1 (ru) 1999-06-24
AP2001002294A0 (en) 2001-12-31
CA2252982A1 (en) 1997-11-13
AR006906A1 (es) 1999-09-29
ZA973804B (en) 1998-11-02
HK1019443A1 (en) 2000-02-11
ID16856A (id) 1997-11-13
KR20000010751A (ko) 2000-02-25
IL152083A0 (en) 2003-05-29
IL126547A0 (en) 1999-08-17
PE64598A1 (es) 1998-10-26
WO1997042174A1 (en) 1997-11-13
HUP9902459A3 (en) 2001-10-29
TW449585B (en) 2001-08-11
CN1422849A (zh) 2003-06-11
DZ2217A1 (fr) 2002-12-03
JP3148254B2 (ja) 2001-03-19
PL329836A1 (en) 1999-04-12
US6127398A (en) 2000-10-03
EA002272B1 (ru) 2002-02-28
AP1147A (en) 2003-02-25
IL126547A (en) 2003-03-12
HUP9902459A2 (hu) 1999-11-29
AU725576B2 (en) 2000-10-12
NZ332240A (en) 2000-07-28
EP0912521B1 (en) 2005-04-06
JPH11508284A (ja) 1999-07-21
DE69732966T2 (de) 2005-09-08
CN1112359C (zh) 2003-06-25
BR9709051A (pt) 1999-08-03
BG64211B1 (bg) 2004-05-31
TNSN97070A1 (fr) 2005-03-15
ATE292626T1 (de) 2005-04-15
HRP970227B1 (en) 2002-06-30
CA2252982C (en) 2002-10-08
MA24158A1 (fr) 1997-12-31
GT199700043A (es) 1998-10-02
TR199802202T2 (xx) 1999-02-22
ES2238079T3 (es) 2005-08-16
BG102946A (en) 1999-11-30
CZ292825B6 (cs) 2003-12-17
AP9700975A0 (en) 1997-07-31
KR100339935B1 (ko) 2002-07-18
DE69732966D1 (de) 2005-05-12
AU1937397A (en) 1997-11-26
AP2001002304A0 (en) 2001-12-31
CN1217714A (zh) 1999-05-26
NO985095L (no) 1998-12-29
EP0912521A1 (en) 1999-05-06
CZ349298A3 (cs) 1999-09-15
CO4650038A1 (es) 1998-09-03
US6211222B1 (en) 2001-04-03
YU16397A (sh) 1999-12-27
CA2389918A1 (en) 1997-11-13
IS4871A (is) 1998-10-16
UA65536C2 (en) 2004-04-15

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